Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells
The nuclear receptor Pparg regulates urothelial differentiation in vitro but its role in healthy urothelium is unclear. Here, the authors show that PPAR gamma mediates urothelial development during both homeostasis (via mitochondrial function) and following infection, via an inflammatory response.
Guardado en:
Autores principales: | Chang Liu, Tiffany Tate, Ekatherina Batourina, Steven T. Truschel, Steven Potter, Mike Adam, Tina Xiang, Martin Picard, Maia Reiley, Kerry Schneider, Manuel Tamargo, Chao Lu, Xiao Chen, Jing He, Hyunwoo Kim, Cathy Lee Mendelsohn |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
|
Materias: | |
Acceso en línea: | https://doaj.org/article/303531835cbf4da28f7e0d26a90b094e |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
PPARG binding landscapes in macrophages suggest a genome-wide contribution of PU.1 to divergent PPARG binding in human and mouse.
por: Sebastian Pott, et al.
Publicado: (2012) -
Association of FTO and PPARG polymorphisms with obesity in Portuguese women
por: Ferreira Carlos F, et al.
Publicado: (2013) -
Stromal protein Ecm1 regulates ureteric bud patterning and branching.
por: Suneeta S Paroly, et al.
Publicado: (2013) -
ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer
por: Wanze Chen, et al.
Publicado: (2019) -
Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers
por: John P. Sfakianos, et al.
Publicado: (2020)