N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease

Neuronal sphingosine kinase 1 (SphK1) acetylates COX2 which is needed for microglial phagocytosis activity, and release of pro-resolving mediators (SPMs) from neurons. Here the authors examine how SphK1-mediates COX2 acetylation, and how this leads to increased secretion of SPMs from neurons in the...

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Autores principales:	Ju Youn Lee, Seung Hoon Han, Min Hee Park, Im-Sook Song, Min-Koo Choi, Eunsoo Yu, Cheol-Min Park, Hee-Jin Kim, Seung Hyun Kim, Edward H. Schuchman, Hee Kyung Jin, Jae-sung Bae
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3035df8592594ac98f3be370c56a59d8
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spelling	oai:doaj.org-article:3035df8592594ac98f3be370c56a59d82021-12-02T16:50:26ZN-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease10.1038/s41467-020-16080-42041-1723https://doaj.org/article/3035df8592594ac98f3be370c56a59d82020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16080-4https://doaj.org/toc/2041-1723Neuronal sphingosine kinase 1 (SphK1) acetylates COX2 which is needed for microglial phagocytosis activity, and release of pro-resolving mediators (SPMs) from neurons. Here the authors examine how SphK1-mediates COX2 acetylation, and how this leads to increased secretion of SPMs from neurons in the context of Alzheimer’s disease models.Ju Youn LeeSeung Hoon HanMin Hee ParkIm-Sook SongMin-Koo ChoiEunsoo YuCheol-Min ParkHee-Jin KimSeung Hyun KimEdward H. SchuchmanHee Kyung JinJae-sung BaeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ju Youn Lee Seung Hoon Han Min Hee Park Im-Sook Song Min-Koo Choi Eunsoo Yu Cheol-Min Park Hee-Jin Kim Seung Hyun Kim Edward H. Schuchman Hee Kyung Jin Jae-sung Bae N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease
description	Neuronal sphingosine kinase 1 (SphK1) acetylates COX2 which is needed for microglial phagocytosis activity, and release of pro-resolving mediators (SPMs) from neurons. Here the authors examine how SphK1-mediates COX2 acetylation, and how this leads to increased secretion of SPMs from neurons in the context of Alzheimer’s disease models.
format	article
author	Ju Youn Lee Seung Hoon Han Min Hee Park Im-Sook Song Min-Koo Choi Eunsoo Yu Cheol-Min Park Hee-Jin Kim Seung Hyun Kim Edward H. Schuchman Hee Kyung Jin Jae-sung Bae
author_facet	Ju Youn Lee Seung Hoon Han Min Hee Park Im-Sook Song Min-Koo Choi Eunsoo Yu Cheol-Min Park Hee-Jin Kim Seung Hyun Kim Edward H. Schuchman Hee Kyung Jin Jae-sung Bae
author_sort	Ju Youn Lee
title	N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease
title_short	N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease
title_full	N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease
title_fullStr	N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease
title_full_unstemmed	N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease
title_sort	n-as-triggered spms are direct regulators of microglia in a model of alzheimer’s disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3035df8592594ac98f3be370c56a59d8
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N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease

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