Characterization of the fecal microbiota of sows and their offspring from German commercial pig farms.

Strategies to combat microbiota-associated health problems are of high interest in pig production. Successful intervention strategies with beneficial long-term effects are still missing. Most studies on pig microbiota have been conducted under standardized experimental conditions, but the situation...

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Autores principales:	Anja Lührmann, Ksenia Ovadenko, Justinus Hellmich, Christoph Sudendey, Vitaly Belik, Jürgen Zentek, Wilfried Vahjen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/30377313662a41dfa644971c17669ae0
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spelling	oai:doaj.org-article:30377313662a41dfa644971c17669ae02021-12-02T20:18:02ZCharacterization of the fecal microbiota of sows and their offspring from German commercial pig farms.1932-620310.1371/journal.pone.0256112https://doaj.org/article/30377313662a41dfa644971c17669ae02021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256112https://doaj.org/toc/1932-6203Strategies to combat microbiota-associated health problems are of high interest in pig production. Successful intervention strategies with beneficial long-term effects are still missing. Most studies on pig microbiota have been conducted under standardized experimental conditions, but the situation in commercial farms differs dramatically. This study describes the fecal microbiota in German commercial pig farms under practical conditions. The study is part of the larger project "Optibiom" that aims to use bacterial composition and farm metadata to formulate tailor-made solutions for farm-specific health maintenance strategies. Special consideration is given to the sow-piglet relationship. Fecal samples from sows and their piglets were collected at two time points each in 20 different farms (sows ante- and postpartum and piglets before and after weaning). The extracted DNA was sequenced with Illumina 16S rDNA sequencing. For data analysis and visualization, differential abundance analyses, as well as hierarchical clustering and nonmetric multidimensional scaling (NMDS) were performed. A new "family unit" was implemented to compare farms based on the association between the microbiota in sows and their offspring. There are distinct changes in the microbial communities in sows before and after birth as well as in suckling and post-weaning piglets. The suckling pig microbiota is particularly different from all other groups and shows a lower bacterial diversity. While dominant genera in antepartum sows further displace the abundance of non-dominant genera postpartum, the opposite was true for piglets, where non-dominant bacteria in the suckling phase became dominant after weaning. The family unit for sows and their piglets led to separate cluster formation for some farms. The results indicate that the sow-piglet relationship is one driving force for the observed differences of the pig farms. The next step in the analysis will be the combination of metadata (feeding, housing and management practices) to find farm-specific differences that can be exploited to formulate a farm-specific health maintenance strategy.Anja LührmannKsenia OvadenkoJustinus HellmichChristoph SudendeyVitaly BelikJürgen ZentekWilfried VahjenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256112 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anja Lührmann Ksenia Ovadenko Justinus Hellmich Christoph Sudendey Vitaly Belik Jürgen Zentek Wilfried Vahjen Characterization of the fecal microbiota of sows and their offspring from German commercial pig farms.
description	Strategies to combat microbiota-associated health problems are of high interest in pig production. Successful intervention strategies with beneficial long-term effects are still missing. Most studies on pig microbiota have been conducted under standardized experimental conditions, but the situation in commercial farms differs dramatically. This study describes the fecal microbiota in German commercial pig farms under practical conditions. The study is part of the larger project "Optibiom" that aims to use bacterial composition and farm metadata to formulate tailor-made solutions for farm-specific health maintenance strategies. Special consideration is given to the sow-piglet relationship. Fecal samples from sows and their piglets were collected at two time points each in 20 different farms (sows ante- and postpartum and piglets before and after weaning). The extracted DNA was sequenced with Illumina 16S rDNA sequencing. For data analysis and visualization, differential abundance analyses, as well as hierarchical clustering and nonmetric multidimensional scaling (NMDS) were performed. A new "family unit" was implemented to compare farms based on the association between the microbiota in sows and their offspring. There are distinct changes in the microbial communities in sows before and after birth as well as in suckling and post-weaning piglets. The suckling pig microbiota is particularly different from all other groups and shows a lower bacterial diversity. While dominant genera in antepartum sows further displace the abundance of non-dominant genera postpartum, the opposite was true for piglets, where non-dominant bacteria in the suckling phase became dominant after weaning. The family unit for sows and their piglets led to separate cluster formation for some farms. The results indicate that the sow-piglet relationship is one driving force for the observed differences of the pig farms. The next step in the analysis will be the combination of metadata (feeding, housing and management practices) to find farm-specific differences that can be exploited to formulate a farm-specific health maintenance strategy.
format	article
author	Anja Lührmann Ksenia Ovadenko Justinus Hellmich Christoph Sudendey Vitaly Belik Jürgen Zentek Wilfried Vahjen
author_facet	Anja Lührmann Ksenia Ovadenko Justinus Hellmich Christoph Sudendey Vitaly Belik Jürgen Zentek Wilfried Vahjen
author_sort	Anja Lührmann
title	Characterization of the fecal microbiota of sows and their offspring from German commercial pig farms.
title_short	Characterization of the fecal microbiota of sows and their offspring from German commercial pig farms.
title_full	Characterization of the fecal microbiota of sows and their offspring from German commercial pig farms.
title_fullStr	Characterization of the fecal microbiota of sows and their offspring from German commercial pig farms.
title_full_unstemmed	Characterization of the fecal microbiota of sows and their offspring from German commercial pig farms.
title_sort	characterization of the fecal microbiota of sows and their offspring from german commercial pig farms.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/30377313662a41dfa644971c17669ae0
work_keys_str_mv	AT anjaluhrmann characterizationofthefecalmicrobiotaofsowsandtheiroffspringfromgermancommercialpigfarms AT kseniaovadenko characterizationofthefecalmicrobiotaofsowsandtheiroffspringfromgermancommercialpigfarms AT justinushellmich characterizationofthefecalmicrobiotaofsowsandtheiroffspringfromgermancommercialpigfarms AT christophsudendey characterizationofthefecalmicrobiotaofsowsandtheiroffspringfromgermancommercialpigfarms AT vitalybelik characterizationofthefecalmicrobiotaofsowsandtheiroffspringfromgermancommercialpigfarms AT jurgenzentek characterizationofthefecalmicrobiotaofsowsandtheiroffspringfromgermancommercialpigfarms AT wilfriedvahjen characterizationofthefecalmicrobiotaofsowsandtheiroffspringfromgermancommercialpigfarms
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Characterization of the fecal microbiota of sows and their offspring from German commercial pig farms.

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