Allosteric coupling between α-rings of the 20S proteasome

The 26S proteasome is a protein degradation machine composed of a 20S core particle (CP) flanked at one or both ends by a 19S ATPase regulatory particle (RP). Here the authors reconstitute asymmetric archaeal proteasomes and reveal allosteric coupling between the conformations of gates in the α-ring...

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Autores principales:	Zanlin Yu, Yadong Yu, Feng Wang, Alexander G. Myasnikov, Philip Coffino, Yifan Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/30380c212df8404498d4bb7e427838f4
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spelling	oai:doaj.org-article:30380c212df8404498d4bb7e427838f42021-12-02T19:12:34ZAllosteric coupling between α-rings of the 20S proteasome10.1038/s41467-020-18415-72041-1723https://doaj.org/article/30380c212df8404498d4bb7e427838f42020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18415-7https://doaj.org/toc/2041-1723The 26S proteasome is a protein degradation machine composed of a 20S core particle (CP) flanked at one or both ends by a 19S ATPase regulatory particle (RP). Here the authors reconstitute asymmetric archaeal proteasomes and reveal allosteric coupling between the conformations of gates in the α-rings positioned at opposite ends of the CP, which modulates RP assembly and substrate entry.Zanlin YuYadong YuFeng WangAlexander G. MyasnikovPhilip CoffinoYifan ChengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zanlin Yu Yadong Yu Feng Wang Alexander G. Myasnikov Philip Coffino Yifan Cheng Allosteric coupling between α-rings of the 20S proteasome
description	The 26S proteasome is a protein degradation machine composed of a 20S core particle (CP) flanked at one or both ends by a 19S ATPase regulatory particle (RP). Here the authors reconstitute asymmetric archaeal proteasomes and reveal allosteric coupling between the conformations of gates in the α-rings positioned at opposite ends of the CP, which modulates RP assembly and substrate entry.
format	article
author	Zanlin Yu Yadong Yu Feng Wang Alexander G. Myasnikov Philip Coffino Yifan Cheng
author_facet	Zanlin Yu Yadong Yu Feng Wang Alexander G. Myasnikov Philip Coffino Yifan Cheng
author_sort	Zanlin Yu
title	Allosteric coupling between α-rings of the 20S proteasome
title_short	Allosteric coupling between α-rings of the 20S proteasome
title_full	Allosteric coupling between α-rings of the 20S proteasome
title_fullStr	Allosteric coupling between α-rings of the 20S proteasome
title_full_unstemmed	Allosteric coupling between α-rings of the 20S proteasome
title_sort	allosteric coupling between α-rings of the 20s proteasome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/30380c212df8404498d4bb7e427838f4
work_keys_str_mv	AT zanlinyu allostericcouplingbetweenaringsofthe20sproteasome AT yadongyu allostericcouplingbetweenaringsofthe20sproteasome AT fengwang allostericcouplingbetweenaringsofthe20sproteasome AT alexandergmyasnikov allostericcouplingbetweenaringsofthe20sproteasome AT philipcoffino allostericcouplingbetweenaringsofthe20sproteasome AT yifancheng allostericcouplingbetweenaringsofthe20sproteasome
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Allosteric coupling between α-rings of the 20S proteasome

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