Allosteric coupling between α-rings of the 20S proteasome

The 26S proteasome is a protein degradation machine composed of a 20S core particle (CP) flanked at one or both ends by a 19S ATPase regulatory particle (RP). Here the authors reconstitute asymmetric archaeal proteasomes and reveal allosteric coupling between the conformations of gates in the α-ring...

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Autores principales: Zanlin Yu, Yadong Yu, Feng Wang, Alexander G. Myasnikov, Philip Coffino, Yifan Cheng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/30380c212df8404498d4bb7e427838f4
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