CASE REPORT: COEXISTENCE OF CELIAC DISEASE AND MULTIPLE MYELOMA

Objective: Celiac disease is a systemic disease in which the natural and adaptive immune system is affected by the effect of gluten exposure and environmental factors in individuals with genetic predisposition. Multiple myeloma; is characterized by an increase in clonal plasma cells. It is the most...

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Autores principales:	Filiz YAVASOGLU, Ciğdem OZDEMIR
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/30381f681bb44a2e9c632c56bf268e9e
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spelling	oai:doaj.org-article:30381f681bb44a2e9c632c56bf268e9e2021-11-10T04:36:27ZCASE REPORT: COEXISTENCE OF CELIAC DISEASE AND MULTIPLE MYELOMA2531-137910.1016/j.htct.2021.10.1044https://doaj.org/article/30381f681bb44a2e9c632c56bf268e9e2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137921011913https://doaj.org/toc/2531-1379Objective: Celiac disease is a systemic disease in which the natural and adaptive immune system is affected by the effect of gluten exposure and environmental factors in individuals with genetic predisposition. Multiple myeloma; is characterized by an increase in clonal plasma cells. It is the most common hematological malignancy after lymphomas.We aimed to present a case siagnosed with celiac disease and multipl myeloma Case report: A 56-year-old female patient with a diagnosis of asthma and celiac disease for 1 year was referred to the Hematology department because her refractory anemia. Serum IgA level of the patient was 4490 mg/dl without renal failure and hypercalcemia.bone marrow biopsy compatible with myeloma. The patient received 6 cycles of bortezomib, cyclophosphamide, and dexamethasone and 3 cycles lenalidomid dexametazon chemotherapy.After chemotherapy, Autologous stem cell transplantation was performed. Conclusion: Celiac disease is an autoimmune disease, characterized by inflammation and villus atrophy in the small intestine mucosa as a result of sensitivity to gluten, resulting in malabsorption. The incidence of lymphoma and gastrointestinal system malignancy is increased in individuals with celiac disease. Multiple myeloma may also be accompanied by autoimmune diseases such as ankylosing spondylitis, scleroderma, and sjögren's syndrome. Coexistence of multiple myeloma and celiac disease is rare.Filiz YAVASOGLUCiğdem OZDEMIRElsevierarticleDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S45- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Filiz YAVASOGLU Ciğdem OZDEMIR CASE REPORT: COEXISTENCE OF CELIAC DISEASE AND MULTIPLE MYELOMA
description	Objective: Celiac disease is a systemic disease in which the natural and adaptive immune system is affected by the effect of gluten exposure and environmental factors in individuals with genetic predisposition. Multiple myeloma; is characterized by an increase in clonal plasma cells. It is the most common hematological malignancy after lymphomas.We aimed to present a case siagnosed with celiac disease and multipl myeloma Case report: A 56-year-old female patient with a diagnosis of asthma and celiac disease for 1 year was referred to the Hematology department because her refractory anemia. Serum IgA level of the patient was 4490 mg/dl without renal failure and hypercalcemia.bone marrow biopsy compatible with myeloma. The patient received 6 cycles of bortezomib, cyclophosphamide, and dexamethasone and 3 cycles lenalidomid dexametazon chemotherapy.After chemotherapy, Autologous stem cell transplantation was performed. Conclusion: Celiac disease is an autoimmune disease, characterized by inflammation and villus atrophy in the small intestine mucosa as a result of sensitivity to gluten, resulting in malabsorption. The incidence of lymphoma and gastrointestinal system malignancy is increased in individuals with celiac disease. Multiple myeloma may also be accompanied by autoimmune diseases such as ankylosing spondylitis, scleroderma, and sjögren's syndrome. Coexistence of multiple myeloma and celiac disease is rare.
format	article
author	Filiz YAVASOGLU Ciğdem OZDEMIR
author_facet	Filiz YAVASOGLU Ciğdem OZDEMIR
author_sort	Filiz YAVASOGLU
title	CASE REPORT: COEXISTENCE OF CELIAC DISEASE AND MULTIPLE MYELOMA
title_short	CASE REPORT: COEXISTENCE OF CELIAC DISEASE AND MULTIPLE MYELOMA
title_full	CASE REPORT: COEXISTENCE OF CELIAC DISEASE AND MULTIPLE MYELOMA
title_fullStr	CASE REPORT: COEXISTENCE OF CELIAC DISEASE AND MULTIPLE MYELOMA
title_full_unstemmed	CASE REPORT: COEXISTENCE OF CELIAC DISEASE AND MULTIPLE MYELOMA
title_sort	case report: coexistence of celiac disease and multiple myeloma
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/30381f681bb44a2e9c632c56bf268e9e
work_keys_str_mv	AT filizyavasoglu casereportcoexistenceofceliacdiseaseandmultiplemyeloma AT cigdemozdemir casereportcoexistenceofceliacdiseaseandmultiplemyeloma
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CASE REPORT: COEXISTENCE OF CELIAC DISEASE AND MULTIPLE MYELOMA

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