Hologenomics: Systems-Level Host Biology

ABSTRACT The hologenome concept of evolution is a hypothesis explaining host evolution in the context of the host microbiomes. As a hypothesis, it needs to be evaluated, especially with respect to the extent of fidelity of transgenerational coassociation of host and microbial lineages and the relati...

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Autor principal:	Kevin R. Theis
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	animal behavior holobiont hologenome microbiome precision medicine Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/303ee122228b404cb6d5819fea2d0769
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id	oai:doaj.org-article:303ee122228b404cb6d5819fea2d0769
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spelling	oai:doaj.org-article:303ee122228b404cb6d5819fea2d07692021-12-02T18:15:47ZHologenomics: Systems-Level Host Biology10.1128/mSystems.00164-172379-5077https://doaj.org/article/303ee122228b404cb6d5819fea2d07692018-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00164-17https://doaj.org/toc/2379-5077ABSTRACT The hologenome concept of evolution is a hypothesis explaining host evolution in the context of the host microbiomes. As a hypothesis, it needs to be evaluated, especially with respect to the extent of fidelity of transgenerational coassociation of host and microbial lineages and the relative fitness consequences of repeated associations within natural holobiont populations. Behavioral ecologists are in a prime position to test these predictions because they typically focus on animal phenotypes that are quantifiable, conduct studies over multiple generations within natural animal populations, and collect metadata on genetic relatedness and relative reproductive success within these populations. Regardless of the conclusion on the hologenome concept as an evolutionary hypothesis, a hologenomic perspective has applied value as a systems-level framework for host biology, including in medicine. Specifically, it emphasizes investigating the multivarious and dynamic interactions between patient genomes and the genomes of their diverse microbiota when attempting to elucidate etiologies of complex, noninfectious diseases.Kevin R. TheisAmerican Society for Microbiologyarticleanimal behaviorholobionthologenomemicrobiomeprecision medicineMicrobiologyQR1-502ENmSystems, Vol 3, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	animal behavior holobiont hologenome microbiome precision medicine Microbiology QR1-502
spellingShingle	animal behavior holobiont hologenome microbiome precision medicine Microbiology QR1-502 Kevin R. Theis Hologenomics: Systems-Level Host Biology
description	ABSTRACT The hologenome concept of evolution is a hypothesis explaining host evolution in the context of the host microbiomes. As a hypothesis, it needs to be evaluated, especially with respect to the extent of fidelity of transgenerational coassociation of host and microbial lineages and the relative fitness consequences of repeated associations within natural holobiont populations. Behavioral ecologists are in a prime position to test these predictions because they typically focus on animal phenotypes that are quantifiable, conduct studies over multiple generations within natural animal populations, and collect metadata on genetic relatedness and relative reproductive success within these populations. Regardless of the conclusion on the hologenome concept as an evolutionary hypothesis, a hologenomic perspective has applied value as a systems-level framework for host biology, including in medicine. Specifically, it emphasizes investigating the multivarious and dynamic interactions between patient genomes and the genomes of their diverse microbiota when attempting to elucidate etiologies of complex, noninfectious diseases.
format	article
author	Kevin R. Theis
author_facet	Kevin R. Theis
author_sort	Kevin R. Theis
title	Hologenomics: Systems-Level Host Biology
title_short	Hologenomics: Systems-Level Host Biology
title_full	Hologenomics: Systems-Level Host Biology
title_fullStr	Hologenomics: Systems-Level Host Biology
title_full_unstemmed	Hologenomics: Systems-Level Host Biology
title_sort	hologenomics: systems-level host biology
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/303ee122228b404cb6d5819fea2d0769
work_keys_str_mv	AT kevinrtheis hologenomicssystemslevelhostbiology
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Hologenomics: Systems-Level Host Biology

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