Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Small molecule probes used to trigger hypoxic response by activating hypoxia inducible factors (HIFs) often lack specificity. Here the authors report a potent small molecule inhibitor that induces hypoxic response by blocking VHL:HIF interactions, providing a selective route to probe hypoxic signall...

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Autores principales:	Julianty Frost, Carles Galdeano, Pedro Soares, Morgan S. Gadd, Katarzyna M. Grzes, Lucy Ellis, Ola Epemolu, Satoko Shimamura, Marcus Bantscheff, Paola Grandi, Kevin D. Read, Doreen A. Cantrell, Sonia Rocha, Alessio Ciulli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3040359d09be44dd8ac2502767cf24e9
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spelling	oai:doaj.org-article:3040359d09be44dd8ac2502767cf24e92021-12-02T15:33:48ZPotent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition10.1038/ncomms133122041-1723https://doaj.org/article/3040359d09be44dd8ac2502767cf24e92016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13312https://doaj.org/toc/2041-1723Small molecule probes used to trigger hypoxic response by activating hypoxia inducible factors (HIFs) often lack specificity. Here the authors report a potent small molecule inhibitor that induces hypoxic response by blocking VHL:HIF interactions, providing a selective route to probe hypoxic signalling.Julianty FrostCarles GaldeanoPedro SoaresMorgan S. GaddKatarzyna M. GrzesLucy EllisOla EpemoluSatoko ShimamuraMarcus BantscheffPaola GrandiKevin D. ReadDoreen A. CantrellSonia RochaAlessio CiulliNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julianty Frost Carles Galdeano Pedro Soares Morgan S. Gadd Katarzyna M. Grzes Lucy Ellis Ola Epemolu Satoko Shimamura Marcus Bantscheff Paola Grandi Kevin D. Read Doreen A. Cantrell Sonia Rocha Alessio Ciulli Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
description	Small molecule probes used to trigger hypoxic response by activating hypoxia inducible factors (HIFs) often lack specificity. Here the authors report a potent small molecule inhibitor that induces hypoxic response by blocking VHL:HIF interactions, providing a selective route to probe hypoxic signalling.
format	article
author	Julianty Frost Carles Galdeano Pedro Soares Morgan S. Gadd Katarzyna M. Grzes Lucy Ellis Ola Epemolu Satoko Shimamura Marcus Bantscheff Paola Grandi Kevin D. Read Doreen A. Cantrell Sonia Rocha Alessio Ciulli
author_facet	Julianty Frost Carles Galdeano Pedro Soares Morgan S. Gadd Katarzyna M. Grzes Lucy Ellis Ola Epemolu Satoko Shimamura Marcus Bantscheff Paola Grandi Kevin D. Read Doreen A. Cantrell Sonia Rocha Alessio Ciulli
author_sort	Julianty Frost
title	Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
title_short	Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
title_full	Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
title_fullStr	Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
title_full_unstemmed	Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
title_sort	potent and selective chemical probe of hypoxic signalling downstream of hif-α hydroxylation via vhl inhibition
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3040359d09be44dd8ac2502767cf24e9
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Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

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