Nanosilver particles in medical applications: synthesis, performance, and toxicity

Liangpeng Ge,1–5,* Qingtao Li,2,3,6,* Meng Wang,2,3 Jun Ouyang,6 Xiaojian Li,7 Malcolm MQ Xing2,31Chongqing Academy of Animal Sciences, Chongqing, People's Republic of China; 2Department of Mechanical and Manufacturing Engineering, Department of Biochemistry and Medical Genetics,...

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Autores principales:	Ge L, Li Q, Wang M, Ouyang J, Li XJ, Xing MM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3044183fce294986b7fc0f407ee8bda2
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spelling	oai:doaj.org-article:3044183fce294986b7fc0f407ee8bda22021-12-02T04:21:09ZNanosilver particles in medical applications: synthesis, performance, and toxicity1178-2013https://doaj.org/article/3044183fce294986b7fc0f407ee8bda22014-05-01T00:00:00Zhttp://www.dovepress.com/nanosilver-particles-in-medical-applications-synthesis-performance-and-a16864https://doaj.org/toc/1178-2013 Liangpeng Ge,1–5,* Qingtao Li,2,3,6,* Meng Wang,2,3 Jun Ouyang,6 Xiaojian Li,7 Malcolm MQ Xing2,31Chongqing Academy of Animal Sciences, Chongqing, People's Republic of China; 2Department of Mechanical and Manufacturing Engineering, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Canada; 3Manitoba Institute of Child Health, Winnipeg, Canada; 4Key Laboratory of Pig Industry Sciences, Ministry of Agriculture, Chongqing, People's Republic of China; 5Key Laboratory of Pig Industry Sciences, Chongqing, People's Republic of China; 6School of Basic Medical Science, Southern Medical University, Guangzhou, People's Republic of China; 7Department of Plastic Surgery, Nanfang Hospital, Guangzhou, People's Republic of China*These authors contributed equally to this work Abstract: Nanosilver particles (NSPs), are among the most attractive nanomaterials, and have been widely used in a range of biomedical applications, including diagnosis, treatment, drug delivery, medical device coating, and for personal health care. With the increasing application of NSPs in medical contexts, it is becoming necessary for a better understanding of the mechanisms of NSPs' biological interactions and their potential toxicity. In this review, we first introduce the synthesis routes of NSPs, including physical, chemical, and biological or green synthesis. Then the unique physiochemical properties of NSPs, such as antibacterial, antifungal, antiviral, and anti-inflammatory activity, are discussed in detail. Further, some recent applications of NSPs in prevention, diagnosis, and treatment in medical fields are described. Finally, potential toxicology considerations of NSPs, both in vitro and in vivo, are also addressed.Keywords: nanosilver particles, synthesis, biomedical application, toxicityGe LLi QWang MOuyang JLi XJXing MMDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 2399-2407 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ge L Li Q Wang M Ouyang J Li XJ Xing MM Nanosilver particles in medical applications: synthesis, performance, and toxicity
description	Liangpeng Ge,1–5,* Qingtao Li,2,3,6,* Meng Wang,2,3 Jun Ouyang,6 Xiaojian Li,7 Malcolm MQ Xing2,31Chongqing Academy of Animal Sciences, Chongqing, People's Republic of China; 2Department of Mechanical and Manufacturing Engineering, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Canada; 3Manitoba Institute of Child Health, Winnipeg, Canada; 4Key Laboratory of Pig Industry Sciences, Ministry of Agriculture, Chongqing, People's Republic of China; 5Key Laboratory of Pig Industry Sciences, Chongqing, People's Republic of China; 6School of Basic Medical Science, Southern Medical University, Guangzhou, People's Republic of China; 7Department of Plastic Surgery, Nanfang Hospital, Guangzhou, People's Republic of China*These authors contributed equally to this work Abstract: Nanosilver particles (NSPs), are among the most attractive nanomaterials, and have been widely used in a range of biomedical applications, including diagnosis, treatment, drug delivery, medical device coating, and for personal health care. With the increasing application of NSPs in medical contexts, it is becoming necessary for a better understanding of the mechanisms of NSPs' biological interactions and their potential toxicity. In this review, we first introduce the synthesis routes of NSPs, including physical, chemical, and biological or green synthesis. Then the unique physiochemical properties of NSPs, such as antibacterial, antifungal, antiviral, and anti-inflammatory activity, are discussed in detail. Further, some recent applications of NSPs in prevention, diagnosis, and treatment in medical fields are described. Finally, potential toxicology considerations of NSPs, both in vitro and in vivo, are also addressed.Keywords: nanosilver particles, synthesis, biomedical application, toxicity
format	article
author	Ge L Li Q Wang M Ouyang J Li XJ Xing MM
author_facet	Ge L Li Q Wang M Ouyang J Li XJ Xing MM
author_sort	Ge L
title	Nanosilver particles in medical applications: synthesis, performance, and toxicity
title_short	Nanosilver particles in medical applications: synthesis, performance, and toxicity
title_full	Nanosilver particles in medical applications: synthesis, performance, and toxicity
title_fullStr	Nanosilver particles in medical applications: synthesis, performance, and toxicity
title_full_unstemmed	Nanosilver particles in medical applications: synthesis, performance, and toxicity
title_sort	nanosilver particles in medical applications: synthesis, performance, and toxicity
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/3044183fce294986b7fc0f407ee8bda2
work_keys_str_mv	AT gel nanosilverparticlesinmedicalapplicationssynthesisperformanceandtoxicity AT liq nanosilverparticlesinmedicalapplicationssynthesisperformanceandtoxicity AT wangm nanosilverparticlesinmedicalapplicationssynthesisperformanceandtoxicity AT ouyangj nanosilverparticlesinmedicalapplicationssynthesisperformanceandtoxicity AT lixj nanosilverparticlesinmedicalapplicationssynthesisperformanceandtoxicity AT xingmm nanosilverparticlesinmedicalapplicationssynthesisperformanceandtoxicity
_version_	1718401301963866112

Nanosilver particles in medical applications: synthesis, performance, and toxicity

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