High-throughput single-cell chromatin accessibility CRISPR screens enable unbiased identification of regulatory networks in cancer

Transcription factor binding dynamics can drive epigenetic states, enabling a diversity of phenotypes. Here the authors present Spear-ATAC to quantify and map perturbations to chromatin accessibility in single cells at high throughput.

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Detalles Bibliográficos
Autores principales:	Sarah E. Pierce, Jeffrey M. Granja, William J. Greenleaf
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/304468b61e004570b0aa5b787c82da4e
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spelling	oai:doaj.org-article:304468b61e004570b0aa5b787c82da4e2021-12-02T14:58:51ZHigh-throughput single-cell chromatin accessibility CRISPR screens enable unbiased identification of regulatory networks in cancer10.1038/s41467-021-23213-w2041-1723https://doaj.org/article/304468b61e004570b0aa5b787c82da4e2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23213-whttps://doaj.org/toc/2041-1723Transcription factor binding dynamics can drive epigenetic states, enabling a diversity of phenotypes. Here the authors present Spear-ATAC to quantify and map perturbations to chromatin accessibility in single cells at high throughput.Sarah E. PierceJeffrey M. GranjaWilliam J. GreenleafNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah E. Pierce Jeffrey M. Granja William J. Greenleaf High-throughput single-cell chromatin accessibility CRISPR screens enable unbiased identification of regulatory networks in cancer
description	Transcription factor binding dynamics can drive epigenetic states, enabling a diversity of phenotypes. Here the authors present Spear-ATAC to quantify and map perturbations to chromatin accessibility in single cells at high throughput.
format	article
author	Sarah E. Pierce Jeffrey M. Granja William J. Greenleaf
author_facet	Sarah E. Pierce Jeffrey M. Granja William J. Greenleaf
author_sort	Sarah E. Pierce
title	High-throughput single-cell chromatin accessibility CRISPR screens enable unbiased identification of regulatory networks in cancer
title_short	High-throughput single-cell chromatin accessibility CRISPR screens enable unbiased identification of regulatory networks in cancer
title_full	High-throughput single-cell chromatin accessibility CRISPR screens enable unbiased identification of regulatory networks in cancer
title_fullStr	High-throughput single-cell chromatin accessibility CRISPR screens enable unbiased identification of regulatory networks in cancer
title_full_unstemmed	High-throughput single-cell chromatin accessibility CRISPR screens enable unbiased identification of regulatory networks in cancer
title_sort	high-throughput single-cell chromatin accessibility crispr screens enable unbiased identification of regulatory networks in cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/304468b61e004570b0aa5b787c82da4e
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High-throughput single-cell chromatin accessibility CRISPR screens enable unbiased identification of regulatory networks in cancer

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