Lymphocyte To High-Density Lipoprotein Ratio As A New Indicator Of Inflammation And Metabolic Syndrome
Haishan Chen,* Chongxiang Xiong, Xiaofei Shao,* Jing Ning, Peichun Gao, Hua Xiao, Yunying Chen, Ziliang Zou, Guobao Hong, Xiaolin Li, Mengjiao Shao, Jieli Sheng, Xingyan Yang, Xu You, Hequn Zou Department of Nephrology, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510630, Pe...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/3048cb2b3eca41a98a91175f5ec34bbc |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:3048cb2b3eca41a98a91175f5ec34bbc |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:3048cb2b3eca41a98a91175f5ec34bbc2021-12-02T00:46:09ZLymphocyte To High-Density Lipoprotein Ratio As A New Indicator Of Inflammation And Metabolic Syndrome1178-7007https://doaj.org/article/3048cb2b3eca41a98a91175f5ec34bbc2019-10-01T00:00:00Zhttps://www.dovepress.com/lymphocyte-to-high-density-lipoprotein-ratio-as-a-new-indicator-of-inf-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Haishan Chen,* Chongxiang Xiong, Xiaofei Shao,* Jing Ning, Peichun Gao, Hua Xiao, Yunying Chen, Ziliang Zou, Guobao Hong, Xiaolin Li, Mengjiao Shao, Jieli Sheng, Xingyan Yang, Xu You, Hequn Zou Department of Nephrology, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510630, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hequn ZouDepartment of Nephrology, The Third Affiliated Hospital, Southern Medical University, 183 Zhongshan West Avenue, Tianhe District, Guangzhou 510630, People’s Republic of ChinaEmail Hequnzou@hotmail.comPurpose: Metabolic syndrome (MetS), which is a global public health problem, is a state of chronic low-grade inflammation. This study looked at the changes in hematological parameters and the predictive value of the lymphocyte to high-density lipoprotein cholesterol (HDL-C) ratio (LHR) as a new index in subjects with and without MetS in coastal cities in southern China.Patients and methods: In this cross-sectional study, there were 852 participants (n = 598 with MetS and n = 254 without MetS). MetS was defined in accordance with the National Cholesterol Education Program, Adult Treatment Panel III (NCEP-ATP III) criteria.Results: MetS was positively correlated with white blood cell count, total lymphocyte count, neutrophil count, red blood cell count, hematocrit, hemoglobin, and high-sensitivity C-reactive protein levels (p<0.05). In addition, there was a positive correlation between LHR and the number of metabolic risk factors for MetS. In a logistic regression analysis, LHR (odds ratio: 4.117; 95% CI: 2.766–6.309; p<0.001) was an independent predictor of MetS. When a receiver operating characteristic (ROC) curve analysis was used to assess the value of LHR for predicting MetS, the area under the curve yielded a cut-off value of 1.657, with a sensitivity of 65% and a specificity of 64% (p<0.0001).Conclusion: In summary, MetS can involve changes in blood parameters, and LHR may be a useful marker of inflammation to assess the presence and severity of MetS.Keywords: inflammation, marker, metabolic syndrome, lymphocyte to high-density lipoprotein cholesterol ratioChen HXiong CShao XNing JGao PXiao HChen YZou ZHong GLi XShao MSheng JYang XYou XZou HDove Medical PressarticleInflammationmarkermetabolic syndromelymphocyte to high-density lipoprotein cholesterol ratioSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 2117-2123 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Inflammation marker metabolic syndrome lymphocyte to high-density lipoprotein cholesterol ratio Specialties of internal medicine RC581-951 |
| spellingShingle |
Inflammation marker metabolic syndrome lymphocyte to high-density lipoprotein cholesterol ratio Specialties of internal medicine RC581-951 Chen H Xiong C Shao X Ning J Gao P Xiao H Chen Y Zou Z Hong G Li X Shao M Sheng J Yang X You X Zou H Lymphocyte To High-Density Lipoprotein Ratio As A New Indicator Of Inflammation And Metabolic Syndrome |
| description |
Haishan Chen,* Chongxiang Xiong, Xiaofei Shao,* Jing Ning, Peichun Gao, Hua Xiao, Yunying Chen, Ziliang Zou, Guobao Hong, Xiaolin Li, Mengjiao Shao, Jieli Sheng, Xingyan Yang, Xu You, Hequn Zou Department of Nephrology, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510630, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hequn ZouDepartment of Nephrology, The Third Affiliated Hospital, Southern Medical University, 183 Zhongshan West Avenue, Tianhe District, Guangzhou 510630, People’s Republic of ChinaEmail Hequnzou@hotmail.comPurpose: Metabolic syndrome (MetS), which is a global public health problem, is a state of chronic low-grade inflammation. This study looked at the changes in hematological parameters and the predictive value of the lymphocyte to high-density lipoprotein cholesterol (HDL-C) ratio (LHR) as a new index in subjects with and without MetS in coastal cities in southern China.Patients and methods: In this cross-sectional study, there were 852 participants (n = 598 with MetS and n = 254 without MetS). MetS was defined in accordance with the National Cholesterol Education Program, Adult Treatment Panel III (NCEP-ATP III) criteria.Results: MetS was positively correlated with white blood cell count, total lymphocyte count, neutrophil count, red blood cell count, hematocrit, hemoglobin, and high-sensitivity C-reactive protein levels (p<0.05). In addition, there was a positive correlation between LHR and the number of metabolic risk factors for MetS. In a logistic regression analysis, LHR (odds ratio: 4.117; 95% CI: 2.766–6.309; p<0.001) was an independent predictor of MetS. When a receiver operating characteristic (ROC) curve analysis was used to assess the value of LHR for predicting MetS, the area under the curve yielded a cut-off value of 1.657, with a sensitivity of 65% and a specificity of 64% (p<0.0001).Conclusion: In summary, MetS can involve changes in blood parameters, and LHR may be a useful marker of inflammation to assess the presence and severity of MetS.Keywords: inflammation, marker, metabolic syndrome, lymphocyte to high-density lipoprotein cholesterol ratio |
| format |
article |
| author |
Chen H Xiong C Shao X Ning J Gao P Xiao H Chen Y Zou Z Hong G Li X Shao M Sheng J Yang X You X Zou H |
| author_facet |
Chen H Xiong C Shao X Ning J Gao P Xiao H Chen Y Zou Z Hong G Li X Shao M Sheng J Yang X You X Zou H |
| author_sort |
Chen H |
| title |
Lymphocyte To High-Density Lipoprotein Ratio As A New Indicator Of Inflammation And Metabolic Syndrome |
| title_short |
Lymphocyte To High-Density Lipoprotein Ratio As A New Indicator Of Inflammation And Metabolic Syndrome |
| title_full |
Lymphocyte To High-Density Lipoprotein Ratio As A New Indicator Of Inflammation And Metabolic Syndrome |
| title_fullStr |
Lymphocyte To High-Density Lipoprotein Ratio As A New Indicator Of Inflammation And Metabolic Syndrome |
| title_full_unstemmed |
Lymphocyte To High-Density Lipoprotein Ratio As A New Indicator Of Inflammation And Metabolic Syndrome |
| title_sort |
lymphocyte to high-density lipoprotein ratio as a new indicator of inflammation and metabolic syndrome |
| publisher |
Dove Medical Press |
| publishDate |
2019 |
| url |
https://doaj.org/article/3048cb2b3eca41a98a91175f5ec34bbc |
| work_keys_str_mv |
AT chenh lymphocytetohighdensitylipoproteinratioasanewindicatorofinflammationandmetabolicsyndrome AT xiongc lymphocytetohighdensitylipoproteinratioasanewindicatorofinflammationandmetabolicsyndrome AT shaox lymphocytetohighdensitylipoproteinratioasanewindicatorofinflammationandmetabolicsyndrome AT ningj lymphocytetohighdensitylipoproteinratioasanewindicatorofinflammationandmetabolicsyndrome AT gaop lymphocytetohighdensitylipoproteinratioasanewindicatorofinflammationandmetabolicsyndrome AT xiaoh lymphocytetohighdensitylipoproteinratioasanewindicatorofinflammationandmetabolicsyndrome AT cheny lymphocytetohighdensitylipoproteinratioasanewindicatorofinflammationandmetabolicsyndrome AT zouz lymphocytetohighdensitylipoproteinratioasanewindicatorofinflammationandmetabolicsyndrome AT hongg lymphocytetohighdensitylipoproteinratioasanewindicatorofinflammationandmetabolicsyndrome AT lix lymphocytetohighdensitylipoproteinratioasanewindicatorofinflammationandmetabolicsyndrome AT shaom lymphocytetohighdensitylipoproteinratioasanewindicatorofinflammationandmetabolicsyndrome AT shengj lymphocytetohighdensitylipoproteinratioasanewindicatorofinflammationandmetabolicsyndrome AT yangx lymphocytetohighdensitylipoproteinratioasanewindicatorofinflammationandmetabolicsyndrome AT youx lymphocytetohighdensitylipoproteinratioasanewindicatorofinflammationandmetabolicsyndrome AT zouh lymphocytetohighdensitylipoproteinratioasanewindicatorofinflammationandmetabolicsyndrome |
| _version_ |
1718403483632140288 |