Evaluation of Age and Sex-Related Metabolic Changes in Healthy Subjects: An Italian Brain 18F-FDG PET Study

Evaluation of Age and Sex-Related Metabolic Changes in Healthy Subjects: An Italian Brain 18F-FDG PET Study

Background: 18F-fluorodeoxyglucose (18F-FDG) positron-emission-tomography (PET) allows detection of cerebral metabolic alterations in neurological diseases vs. normal aging. We assess age- and sex-related brain metabolic changes in healthy subjects, exploring impact of activity normalization methods...

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Autores principales: Michela Allocca, Flavia Linguanti, Maria Lucia Calcagni, Angelina Cistaro, Valeria Gaudieri, Ugo Paolo Guerra, Silvia Morbelli, Flavio Nobili, Sabina Pappatà, Stelvio Sestini, Duccio Volterrani, Valentina Berti, for the Neurology Study Group of the Italian Association of Nuclear Medicine
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
fluorodeoxyglucose
18F-FDG
positron-emission tomography
PET imaging
brain
healthy aging
Medicine
R
Acceso en línea:https://doaj.org/article/304e09c75530429e8dd18c969fec1f52
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spelling oai:doaj.org-article:304e09c75530429e8dd18c969fec1f522021-11-11T17:34:18ZEvaluation of Age and Sex-Related Metabolic Changes in Healthy Subjects: An Italian Brain 18F-FDG PET Study10.3390/jcm102149322077-0383https://doaj.org/article/304e09c75530429e8dd18c969fec1f522021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4932https://doaj.org/toc/2077-0383Background: 18F-fluorodeoxyglucose (18F-FDG) positron-emission-tomography (PET) allows detection of cerebral metabolic alterations in neurological diseases vs. normal aging. We assess age- and sex-related brain metabolic changes in healthy subjects, exploring impact of activity normalization methods. Methods: brain scans of Italian Association of Nuclear Medicine normative database (151 subjects, 67 Males, 84 Females, aged 20–84) were selected. Global mean, white matter, and pons activity were explored as normalization reference. We performed voxel-based and ROI analyses using SPM12 and IBM-SPSS software. Results: SPM proved a negative correlation between age and brain glucose metabolism involving frontal lobes, anterior-cingulate and insular cortices bilaterally. Narrower clusters were detected in lateral parietal lobes, precuneus, temporal pole and medial areas bilaterally. Normalizing on pons activity, we found a more significant negative correlation and no positive one. ROIs analysis confirmed SPM results. Moreover, a significant age × sex interaction effect was revealed, with worse metabolic reduction in posterior-cingulate cortices in females than males, especially in post-menopausal age. Conclusions: this study demonstrated an age-related metabolic reduction in frontal lobes and in some parieto-temporal areas more evident in females. Results suggested pons as the most appropriate normalization reference. Knowledge of age- and sex-related cerebral metabolic changes is critical to correctly interpreting brain 18F-FDG PET imaging.Michela AlloccaFlavia LinguantiMaria Lucia CalcagniAngelina CistaroValeria GaudieriUgo Paolo GuerraSilvia MorbelliFlavio NobiliSabina PappatàStelvio SestiniDuccio VolterraniValentina Bertifor the Neurology Study Group of the Italian Association of Nuclear MedicineMDPI AGarticlefluorodeoxyglucose18F-FDGpositron-emission tomographyPET imagingbrainhealthy agingMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4932, p 4932 (2021)
institution DOAJ
collection DOAJ
language EN
topic fluorodeoxyglucose
18F-FDG
positron-emission tomography
PET imaging
brain
healthy aging
Medicine
R
spellingShingle fluorodeoxyglucose
18F-FDG
positron-emission tomography
PET imaging
brain
healthy aging
Medicine
R
Michela Allocca
Flavia Linguanti
Maria Lucia Calcagni
Angelina Cistaro
Valeria Gaudieri
Ugo Paolo Guerra
Silvia Morbelli
Flavio Nobili
Sabina Pappatà
Stelvio Sestini
Duccio Volterrani
Valentina Berti
for the Neurology Study Group of the Italian Association of Nuclear Medicine
Evaluation of Age and Sex-Related Metabolic Changes in Healthy Subjects: An Italian Brain 18F-FDG PET Study
description Background: 18F-fluorodeoxyglucose (18F-FDG) positron-emission-tomography (PET) allows detection of cerebral metabolic alterations in neurological diseases vs. normal aging. We assess age- and sex-related brain metabolic changes in healthy subjects, exploring impact of activity normalization methods. Methods: brain scans of Italian Association of Nuclear Medicine normative database (151 subjects, 67 Males, 84 Females, aged 20–84) were selected. Global mean, white matter, and pons activity were explored as normalization reference. We performed voxel-based and ROI analyses using SPM12 and IBM-SPSS software. Results: SPM proved a negative correlation between age and brain glucose metabolism involving frontal lobes, anterior-cingulate and insular cortices bilaterally. Narrower clusters were detected in lateral parietal lobes, precuneus, temporal pole and medial areas bilaterally. Normalizing on pons activity, we found a more significant negative correlation and no positive one. ROIs analysis confirmed SPM results. Moreover, a significant age × sex interaction effect was revealed, with worse metabolic reduction in posterior-cingulate cortices in females than males, especially in post-menopausal age. Conclusions: this study demonstrated an age-related metabolic reduction in frontal lobes and in some parieto-temporal areas more evident in females. Results suggested pons as the most appropriate normalization reference. Knowledge of age- and sex-related cerebral metabolic changes is critical to correctly interpreting brain 18F-FDG PET imaging.
format article
author Michela Allocca
Flavia Linguanti
Maria Lucia Calcagni
Angelina Cistaro
Valeria Gaudieri
Ugo Paolo Guerra
Silvia Morbelli
Flavio Nobili
Sabina Pappatà
Stelvio Sestini
Duccio Volterrani
Valentina Berti
for the Neurology Study Group of the Italian Association of Nuclear Medicine
author_facet Michela Allocca
Flavia Linguanti
Maria Lucia Calcagni
Angelina Cistaro
Valeria Gaudieri
Ugo Paolo Guerra
Silvia Morbelli
Flavio Nobili
Sabina Pappatà
Stelvio Sestini
Duccio Volterrani
Valentina Berti
for the Neurology Study Group of the Italian Association of Nuclear Medicine
author_sort Michela Allocca
title Evaluation of Age and Sex-Related Metabolic Changes in Healthy Subjects: An Italian Brain 18F-FDG PET Study
title_short Evaluation of Age and Sex-Related Metabolic Changes in Healthy Subjects: An Italian Brain 18F-FDG PET Study
title_full Evaluation of Age and Sex-Related Metabolic Changes in Healthy Subjects: An Italian Brain 18F-FDG PET Study
title_fullStr Evaluation of Age and Sex-Related Metabolic Changes in Healthy Subjects: An Italian Brain 18F-FDG PET Study
title_full_unstemmed Evaluation of Age and Sex-Related Metabolic Changes in Healthy Subjects: An Italian Brain 18F-FDG PET Study
title_sort evaluation of age and sex-related metabolic changes in healthy subjects: an italian brain 18f-fdg pet study
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/304e09c75530429e8dd18c969fec1f52
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