A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells

The tyrosine-kinases Fer/FerT associate with the mitochondrial electron transport chain in cancer cells supporting their metabolic reprogramming. Here the authors discover a compound that disrupts Fer /FerT activity and selectively induces cell death of cancer cell lines displaying anti-tumor activi...

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Autores principales:	Yoav Elkis, Moshe Cohen, Etai Yaffe, Shirly Satmary-Tusk, Tal Feldman, Elad Hikri, Abraham Nyska, Ariel Feiglin, Yanay Ofran, Sally Shpungin, Uri Nir
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/304f5bb8d7d547729246064abf8f6e96
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spelling	oai:doaj.org-article:304f5bb8d7d547729246064abf8f6e962021-12-02T17:06:10ZA novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells10.1038/s41467-017-00832-w2041-1723https://doaj.org/article/304f5bb8d7d547729246064abf8f6e962017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00832-whttps://doaj.org/toc/2041-1723The tyrosine-kinases Fer/FerT associate with the mitochondrial electron transport chain in cancer cells supporting their metabolic reprogramming. Here the authors discover a compound that disrupts Fer /FerT activity and selectively induces cell death of cancer cell lines displaying anti-tumor activity in vivo.Yoav ElkisMoshe CohenEtai YaffeShirly Satmary-TuskTal FeldmanElad HikriAbraham NyskaAriel FeiglinYanay OfranSally ShpunginUri NirNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yoav Elkis Moshe Cohen Etai Yaffe Shirly Satmary-Tusk Tal Feldman Elad Hikri Abraham Nyska Ariel Feiglin Yanay Ofran Sally Shpungin Uri Nir A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells
description	The tyrosine-kinases Fer/FerT associate with the mitochondrial electron transport chain in cancer cells supporting their metabolic reprogramming. Here the authors discover a compound that disrupts Fer /FerT activity and selectively induces cell death of cancer cell lines displaying anti-tumor activity in vivo.
format	article
author	Yoav Elkis Moshe Cohen Etai Yaffe Shirly Satmary-Tusk Tal Feldman Elad Hikri Abraham Nyska Ariel Feiglin Yanay Ofran Sally Shpungin Uri Nir
author_facet	Yoav Elkis Moshe Cohen Etai Yaffe Shirly Satmary-Tusk Tal Feldman Elad Hikri Abraham Nyska Ariel Feiglin Yanay Ofran Sally Shpungin Uri Nir
author_sort	Yoav Elkis
title	A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells
title_short	A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells
title_full	A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells
title_fullStr	A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells
title_full_unstemmed	A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells
title_sort	novel fer/fert targeting compound selectively evokes metabolic stress and necrotic death in malignant cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/304f5bb8d7d547729246064abf8f6e96
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A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells

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