What is new for an old molecule? Systematic review and recommendations on the use of resveratrol.
<h4>Background</h4>Resveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning th...
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2011
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oai:doaj.org-article:304fb5edd52c42c799f803f46c240e792021-11-18T06:51:53ZWhat is new for an old molecule? Systematic review and recommendations on the use of resveratrol.1932-620310.1371/journal.pone.0019881https://doaj.org/article/304fb5edd52c42c799f803f46c240e792011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21698226/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Resveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data are necessary. Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in Helsingør, Denmark.<h4>Methodology</h4>Literature search in databases as PUBMED and ISI Web of Science in combination with manual search was used to answer the following five questions: (1)Can resveratrol be recommended in the prevention or treatment of human diseases?; (2)Are there observed "side effects" caused by the intake of resveratrol in humans?; (3)What is the relevant dose of resveratrol?; (4)What valid data are available regarding an effect in various species of experimental animals?; (5)Which relevant (overall) mechanisms of action of resveratrol have been documented?<h4>Conclusions/significance</h4>The overall conclusion is that the published evidence is not sufficiently strong to justify a recommendation for the administration of resveratrol to humans, beyond the dose which can be obtained from dietary sources. On the other hand, animal data are promising in prevention of various cancer types, coronary heart diseases and diabetes which strongly indicate the need for human clinical trials. Finally, we suggest directions for future research in resveratrol regarding its mechanism of action and its safety and toxicology in human subjects.Ole VangNihal AhmadClifton A BaileJoseph A BaurKaren BrownAnna CsiszarDipak K DasDominique DelmasCarmem GottfriedHung-Yun LinQing-Yong MaPartha MukhopadhyayNamasivayam NaliniJohn M PezzutoTristan RichardYogeshwer ShuklaYoung-Joon SurhThomas SzekeresTomasz SzkudelskiThomas WalleJoseph M WuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e19881 (2011) |
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Medicine R Science Q |
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Medicine R Science Q Ole Vang Nihal Ahmad Clifton A Baile Joseph A Baur Karen Brown Anna Csiszar Dipak K Das Dominique Delmas Carmem Gottfried Hung-Yun Lin Qing-Yong Ma Partha Mukhopadhyay Namasivayam Nalini John M Pezzuto Tristan Richard Yogeshwer Shukla Young-Joon Surh Thomas Szekeres Tomasz Szkudelski Thomas Walle Joseph M Wu What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. |
| description |
<h4>Background</h4>Resveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data are necessary. Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in Helsingør, Denmark.<h4>Methodology</h4>Literature search in databases as PUBMED and ISI Web of Science in combination with manual search was used to answer the following five questions: (1)Can resveratrol be recommended in the prevention or treatment of human diseases?; (2)Are there observed "side effects" caused by the intake of resveratrol in humans?; (3)What is the relevant dose of resveratrol?; (4)What valid data are available regarding an effect in various species of experimental animals?; (5)Which relevant (overall) mechanisms of action of resveratrol have been documented?<h4>Conclusions/significance</h4>The overall conclusion is that the published evidence is not sufficiently strong to justify a recommendation for the administration of resveratrol to humans, beyond the dose which can be obtained from dietary sources. On the other hand, animal data are promising in prevention of various cancer types, coronary heart diseases and diabetes which strongly indicate the need for human clinical trials. Finally, we suggest directions for future research in resveratrol regarding its mechanism of action and its safety and toxicology in human subjects. |
| format |
article |
| author |
Ole Vang Nihal Ahmad Clifton A Baile Joseph A Baur Karen Brown Anna Csiszar Dipak K Das Dominique Delmas Carmem Gottfried Hung-Yun Lin Qing-Yong Ma Partha Mukhopadhyay Namasivayam Nalini John M Pezzuto Tristan Richard Yogeshwer Shukla Young-Joon Surh Thomas Szekeres Tomasz Szkudelski Thomas Walle Joseph M Wu |
| author_facet |
Ole Vang Nihal Ahmad Clifton A Baile Joseph A Baur Karen Brown Anna Csiszar Dipak K Das Dominique Delmas Carmem Gottfried Hung-Yun Lin Qing-Yong Ma Partha Mukhopadhyay Namasivayam Nalini John M Pezzuto Tristan Richard Yogeshwer Shukla Young-Joon Surh Thomas Szekeres Tomasz Szkudelski Thomas Walle Joseph M Wu |
| author_sort |
Ole Vang |
| title |
What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. |
| title_short |
What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. |
| title_full |
What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. |
| title_fullStr |
What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. |
| title_full_unstemmed |
What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. |
| title_sort |
what is new for an old molecule? systematic review and recommendations on the use of resveratrol. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/304fb5edd52c42c799f803f46c240e79 |
| work_keys_str_mv |
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