The diagnostic value of D-dimer in acute aortic dissection: a meta-analysis

Abstract Objective This study aims to evaluate the diagnostic value of D-dimer for acute aortic dissection (AAD) by the method of meta-analysis. Methods PubMed, Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), and Wanfang databases from the establishment of t...

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Autores principales:	Jian Yao, Tao Bai, Bo Yang, Lizhong Sun
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	D-dimer Acute aortic dissection Meta-analysis Diagnostic value Surgery RD1-811 Anesthesiology RD78.3-87.3
Acceso en línea:	https://doaj.org/article/304fcf80e68a4a188836acf48ac65fa5
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spelling	oai:doaj.org-article:304fcf80e68a4a188836acf48ac65fa52021-11-28T12:30:56ZThe diagnostic value of D-dimer in acute aortic dissection: a meta-analysis10.1186/s13019-021-01726-11749-8090https://doaj.org/article/304fcf80e68a4a188836acf48ac65fa52021-11-01T00:00:00Zhttps://doi.org/10.1186/s13019-021-01726-1https://doaj.org/toc/1749-8090Abstract Objective This study aims to evaluate the diagnostic value of D-dimer for acute aortic dissection (AAD) by the method of meta-analysis. Methods PubMed, Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), and Wanfang databases from the establishment of the databases to December 2020 were systematically searched, and the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) system was used to evaluate the quality of the literature. STATA 15.0 software was applied to calculate the pooled sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (+LR), negative likelihood ratio (−LR) to draw summary receiver operating characteristics (SROC) curve and calculate the area under the curve (AUC). Meta-regression and subgroup analyses were used to explore the source of heterogeneity. Results A total of 16 clinical studies were enrolled in this study, including 1135 patients. The results of the meta-analysis showed that the pooled sensitivity was 0.96 (95% CI 0.91–0.98), the pooled specificity was 0.70 (95% CI 0.57–0.81), and the pooled DOR was 56.57 (95% CI 25.11–127.44), the pooled +LR was 3.25 (95% CI 2.18–4.85), the pooled −LR was 0.06 (95% CI 0.03–0.12), and the AUC was 0.94 (95% CI 0.91–0.95). Meta-regression and subgroup analysis results showed that publication year, sample size and cutoff value might be sources of heterogeneity. When the concentration of D-dimer was less than or equal to 500 ng/ml, the sensitivity significantly increased. Conclusion D-dimer has an excellent diagnostic value for AAD. It is a useful tool for detecting suspected AAD because of the excellent pooled sensitivity. D-dimer ≤ 500 ng/ml increases the potential to identify the suspected patients with AAD.Jian YaoTao BaiBo YangLizhong SunBMCarticleD-dimerAcute aortic dissectionMeta-analysisDiagnostic valueSurgeryRD1-811AnesthesiologyRD78.3-87.3ENJournal of Cardiothoracic Surgery, Vol 16, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	D-dimer Acute aortic dissection Meta-analysis Diagnostic value Surgery RD1-811 Anesthesiology RD78.3-87.3
spellingShingle	D-dimer Acute aortic dissection Meta-analysis Diagnostic value Surgery RD1-811 Anesthesiology RD78.3-87.3 Jian Yao Tao Bai Bo Yang Lizhong Sun The diagnostic value of D-dimer in acute aortic dissection: a meta-analysis
description	Abstract Objective This study aims to evaluate the diagnostic value of D-dimer for acute aortic dissection (AAD) by the method of meta-analysis. Methods PubMed, Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), and Wanfang databases from the establishment of the databases to December 2020 were systematically searched, and the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) system was used to evaluate the quality of the literature. STATA 15.0 software was applied to calculate the pooled sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (+LR), negative likelihood ratio (−LR) to draw summary receiver operating characteristics (SROC) curve and calculate the area under the curve (AUC). Meta-regression and subgroup analyses were used to explore the source of heterogeneity. Results A total of 16 clinical studies were enrolled in this study, including 1135 patients. The results of the meta-analysis showed that the pooled sensitivity was 0.96 (95% CI 0.91–0.98), the pooled specificity was 0.70 (95% CI 0.57–0.81), and the pooled DOR was 56.57 (95% CI 25.11–127.44), the pooled +LR was 3.25 (95% CI 2.18–4.85), the pooled −LR was 0.06 (95% CI 0.03–0.12), and the AUC was 0.94 (95% CI 0.91–0.95). Meta-regression and subgroup analysis results showed that publication year, sample size and cutoff value might be sources of heterogeneity. When the concentration of D-dimer was less than or equal to 500 ng/ml, the sensitivity significantly increased. Conclusion D-dimer has an excellent diagnostic value for AAD. It is a useful tool for detecting suspected AAD because of the excellent pooled sensitivity. D-dimer ≤ 500 ng/ml increases the potential to identify the suspected patients with AAD.
format	article
author	Jian Yao Tao Bai Bo Yang Lizhong Sun
author_facet	Jian Yao Tao Bai Bo Yang Lizhong Sun
author_sort	Jian Yao
title	The diagnostic value of D-dimer in acute aortic dissection: a meta-analysis
title_short	The diagnostic value of D-dimer in acute aortic dissection: a meta-analysis
title_full	The diagnostic value of D-dimer in acute aortic dissection: a meta-analysis
title_fullStr	The diagnostic value of D-dimer in acute aortic dissection: a meta-analysis
title_full_unstemmed	The diagnostic value of D-dimer in acute aortic dissection: a meta-analysis
title_sort	diagnostic value of d-dimer in acute aortic dissection: a meta-analysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/304fcf80e68a4a188836acf48ac65fa5
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The diagnostic value of D-dimer in acute aortic dissection: a meta-analysis

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