TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells

LPS is a major component of gram-negative bacterial cell walls, and triggers immune responses in airway epithelium by activating TLR4. Here the authors show that LPS also activates TRPV4, thereby inducing fast defense responses such as nitric oxide production and increased ciliary beating in mice.

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Autores principales:	Yeranddy A. Alpizar, Brett Boonen, Alicia Sanchez, Carole Jung, Alejandro López-Requena, Robbe Naert, Brecht Steelant, Katrien Luyts, Cristina Plata, Vanessa De Vooght, Jeroen A. J. Vanoirbeek, Victor M. Meseguer, Thomas Voets, Julio L. Alvarez, Peter W. Hellings, Peter H. M. Hoet, Benoit Nemery, Miguel A. Valverde, Karel Talavera
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/305c11c87f63412e9d5471df82642beb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:305c11c87f63412e9d5471df82642beb2021-12-02T14:41:19ZTRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells10.1038/s41467-017-01201-32041-1723https://doaj.org/article/305c11c87f63412e9d5471df82642beb2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01201-3https://doaj.org/toc/2041-1723LPS is a major component of gram-negative bacterial cell walls, and triggers immune responses in airway epithelium by activating TLR4. Here the authors show that LPS also activates TRPV4, thereby inducing fast defense responses such as nitric oxide production and increased ciliary beating in mice.Yeranddy A. AlpizarBrett BoonenAlicia SanchezCarole JungAlejandro López-RequenaRobbe NaertBrecht SteelantKatrien LuytsCristina PlataVanessa De VooghtJeroen A. J. VanoirbeekVictor M. MeseguerThomas VoetsJulio L. AlvarezPeter W. HellingsPeter H. M. HoetBenoit NemeryMiguel A. ValverdeKarel TalaveraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yeranddy A. Alpizar Brett Boonen Alicia Sanchez Carole Jung Alejandro López-Requena Robbe Naert Brecht Steelant Katrien Luyts Cristina Plata Vanessa De Vooght Jeroen A. J. Vanoirbeek Victor M. Meseguer Thomas Voets Julio L. Alvarez Peter W. Hellings Peter H. M. Hoet Benoit Nemery Miguel A. Valverde Karel Talavera TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells
description	LPS is a major component of gram-negative bacterial cell walls, and triggers immune responses in airway epithelium by activating TLR4. Here the authors show that LPS also activates TRPV4, thereby inducing fast defense responses such as nitric oxide production and increased ciliary beating in mice.
format	article
author	Yeranddy A. Alpizar Brett Boonen Alicia Sanchez Carole Jung Alejandro López-Requena Robbe Naert Brecht Steelant Katrien Luyts Cristina Plata Vanessa De Vooght Jeroen A. J. Vanoirbeek Victor M. Meseguer Thomas Voets Julio L. Alvarez Peter W. Hellings Peter H. M. Hoet Benoit Nemery Miguel A. Valverde Karel Talavera
author_facet	Yeranddy A. Alpizar Brett Boonen Alicia Sanchez Carole Jung Alejandro López-Requena Robbe Naert Brecht Steelant Katrien Luyts Cristina Plata Vanessa De Vooght Jeroen A. J. Vanoirbeek Victor M. Meseguer Thomas Voets Julio L. Alvarez Peter W. Hellings Peter H. M. Hoet Benoit Nemery Miguel A. Valverde Karel Talavera
author_sort	Yeranddy A. Alpizar
title	TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells
title_short	TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells
title_full	TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells
title_fullStr	TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells
title_full_unstemmed	TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells
title_sort	trpv4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/305c11c87f63412e9d5471df82642beb
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TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells

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