Using Maggot Debridement Therapy in Treatment of Necrosis in the Forearm Caused By Docetaxel Extravasation: A Case Report

Extravasation of doxorubicin, vincristine or vinblastine leads to necrosis, damage of the muscles and nerves, deep ulceration, as well as limb dysfunction. Necrosis and deep ulcers develop within 7 to 28 days. Like necrotomy, Lucilia sericata maggot therapy is recognised as a method enabling effecti...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dariusz Bazaliński, Joanna Przybek-Mita, Marek Kucharzewski, Paweł Więch
Formato:	article
Lenguaje:	EN
Publicado:	Tehran University of Medical Sciences 2021
Materias:	maggot deberidement therapy larvae cytostatics extravasation Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/305cbdd1708c463c884dd174b4acb185
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:305cbdd1708c463c884dd174b4acb185
record_format	dspace
spelling	oai:doaj.org-article:305cbdd1708c463c884dd174b4acb1852021-11-29T07:18:54ZUsing Maggot Debridement Therapy in Treatment of Necrosis in the Forearm Caused By Docetaxel Extravasation: A Case Report1735-70202008-238Xhttps://doaj.org/article/305cbdd1708c463c884dd174b4acb1852021-11-01T00:00:00Zhttps://ijpa.tums.ac.ir/index.php/ijpa/article/view/3238https://doaj.org/toc/1735-7020https://doaj.org/toc/2008-238XExtravasation of doxorubicin, vincristine or vinblastine leads to necrosis, damage of the muscles and nerves, deep ulceration, as well as limb dysfunction. Necrosis and deep ulcers develop within 7 to 28 days. Like necrotomy, Lucilia sericata maggot therapy is recognised as a method enabling effective, safe and quick removal of necrotic tissue. The purpose of the study was to present local treatment of hypodermic necrosis caused by docetaxel extravasation in course of systemic cancer therapy. A woman, 59 years of age, in course of systemic therapy due to advanced cancer of the left breast (T2N1M1 CS IV) with confirmed metastases within the body of the fourth lumbar vertebra and in the liver, receiving a combination treatment with pertuzumab, trastuzumab, and docetaxel. During the therapy, a conservative treatment was applied due to extravasation for over three months. Effects in the right forearm included swelling, redness, signs of 4x10cm inflammatory infiltrate, with 1x4cm necrotic crust visible in the central region. Hypodermic necrosis was debrided using L. sericata maggots, and subsequently specialist dressings were applied to promote granulation and healing. In the case discussed here, effectiveness of MDT was rather poor, however the treatment minimised the risk of infection associated with evacuation of necrosis. Attempts to use MDT should be continued to enable more comprehensive understanding of problems related to management of necrosis in wounds developing during cancer therapy.Dariusz BazalińskiJoanna Przybek-MitaMarek KucharzewskiPaweł WięchTehran University of Medical Sciencesarticlemaggot deberidement therapylarvaecytostatics extravasationInfectious and parasitic diseasesRC109-216ENIranian Journal of Parasitology, Vol 16, Iss 4, Pp 703-710 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	maggot deberidement therapy larvae cytostatics extravasation Infectious and parasitic diseases RC109-216
spellingShingle	maggot deberidement therapy larvae cytostatics extravasation Infectious and parasitic diseases RC109-216 Dariusz Bazaliński Joanna Przybek-Mita Marek Kucharzewski Paweł Więch Using Maggot Debridement Therapy in Treatment of Necrosis in the Forearm Caused By Docetaxel Extravasation: A Case Report
description	Extravasation of doxorubicin, vincristine or vinblastine leads to necrosis, damage of the muscles and nerves, deep ulceration, as well as limb dysfunction. Necrosis and deep ulcers develop within 7 to 28 days. Like necrotomy, Lucilia sericata maggot therapy is recognised as a method enabling effective, safe and quick removal of necrotic tissue. The purpose of the study was to present local treatment of hypodermic necrosis caused by docetaxel extravasation in course of systemic cancer therapy. A woman, 59 years of age, in course of systemic therapy due to advanced cancer of the left breast (T2N1M1 CS IV) with confirmed metastases within the body of the fourth lumbar vertebra and in the liver, receiving a combination treatment with pertuzumab, trastuzumab, and docetaxel. During the therapy, a conservative treatment was applied due to extravasation for over three months. Effects in the right forearm included swelling, redness, signs of 4x10cm inflammatory infiltrate, with 1x4cm necrotic crust visible in the central region. Hypodermic necrosis was debrided using L. sericata maggots, and subsequently specialist dressings were applied to promote granulation and healing. In the case discussed here, effectiveness of MDT was rather poor, however the treatment minimised the risk of infection associated with evacuation of necrosis. Attempts to use MDT should be continued to enable more comprehensive understanding of problems related to management of necrosis in wounds developing during cancer therapy.
format	article
author	Dariusz Bazaliński Joanna Przybek-Mita Marek Kucharzewski Paweł Więch
author_facet	Dariusz Bazaliński Joanna Przybek-Mita Marek Kucharzewski Paweł Więch
author_sort	Dariusz Bazaliński
title	Using Maggot Debridement Therapy in Treatment of Necrosis in the Forearm Caused By Docetaxel Extravasation: A Case Report
title_short	Using Maggot Debridement Therapy in Treatment of Necrosis in the Forearm Caused By Docetaxel Extravasation: A Case Report
title_full	Using Maggot Debridement Therapy in Treatment of Necrosis in the Forearm Caused By Docetaxel Extravasation: A Case Report
title_fullStr	Using Maggot Debridement Therapy in Treatment of Necrosis in the Forearm Caused By Docetaxel Extravasation: A Case Report
title_full_unstemmed	Using Maggot Debridement Therapy in Treatment of Necrosis in the Forearm Caused By Docetaxel Extravasation: A Case Report
title_sort	using maggot debridement therapy in treatment of necrosis in the forearm caused by docetaxel extravasation: a case report
publisher	Tehran University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/305cbdd1708c463c884dd174b4acb185
work_keys_str_mv	AT dariuszbazalinski usingmaggotdebridementtherapyintreatmentofnecrosisintheforearmcausedbydocetaxelextravasationacasereport AT joannaprzybekmita usingmaggotdebridementtherapyintreatmentofnecrosisintheforearmcausedbydocetaxelextravasationacasereport AT marekkucharzewski usingmaggotdebridementtherapyintreatmentofnecrosisintheforearmcausedbydocetaxelextravasationacasereport AT pawełwiech usingmaggotdebridementtherapyintreatmentofnecrosisintheforearmcausedbydocetaxelextravasationacasereport
_version_	1718407515553660928

Using Maggot Debridement Therapy in Treatment of Necrosis in the Forearm Caused By Docetaxel Extravasation: A Case Report

Ejemplares similares