Using apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors

Cellular markers of endothelial cell proliferation help identify the vasculature of tumours in homeostasis. Here, the authors report Apelin-based synthetic Notch (synNotch) receptors that can target Apj expressed on endothelium and stimulate the synNotch pathways upon Apj binding, and suggest this a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhifu Wang, Fan Wang, Junjie Zhong, Tongming Zhu, Yongtao Zheng, Tong Zhao, Qiang Xie, Fukai Ma, Ronggang Li, Qisheng Tang, Feng Xu, Xueying Tian, Jianhong Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/305d2282cec8462487328efffb5cd954
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:305d2282cec8462487328efffb5cd954
record_format	dspace
spelling	oai:doaj.org-article:305d2282cec8462487328efffb5cd9542021-12-02T17:31:24ZUsing apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors10.1038/s41467-020-15729-42041-1723https://doaj.org/article/305d2282cec8462487328efffb5cd9542020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15729-4https://doaj.org/toc/2041-1723Cellular markers of endothelial cell proliferation help identify the vasculature of tumours in homeostasis. Here, the authors report Apelin-based synthetic Notch (synNotch) receptors that can target Apj expressed on endothelium and stimulate the synNotch pathways upon Apj binding, and suggest this as a strategy to treat solid tumours.Zhifu WangFan WangJunjie ZhongTongming ZhuYongtao ZhengTong ZhaoQiang XieFukai MaRonggang LiQisheng TangFeng XuXueying TianJianhong ZhuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhifu Wang Fan Wang Junjie Zhong Tongming Zhu Yongtao Zheng Tong Zhao Qiang Xie Fukai Ma Ronggang Li Qisheng Tang Feng Xu Xueying Tian Jianhong Zhu Using apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors
description	Cellular markers of endothelial cell proliferation help identify the vasculature of tumours in homeostasis. Here, the authors report Apelin-based synthetic Notch (synNotch) receptors that can target Apj expressed on endothelium and stimulate the synNotch pathways upon Apj binding, and suggest this as a strategy to treat solid tumours.
format	article
author	Zhifu Wang Fan Wang Junjie Zhong Tongming Zhu Yongtao Zheng Tong Zhao Qiang Xie Fukai Ma Ronggang Li Qisheng Tang Feng Xu Xueying Tian Jianhong Zhu
author_facet	Zhifu Wang Fan Wang Junjie Zhong Tongming Zhu Yongtao Zheng Tong Zhao Qiang Xie Fukai Ma Ronggang Li Qisheng Tang Feng Xu Xueying Tian Jianhong Zhu
author_sort	Zhifu Wang
title	Using apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors
title_short	Using apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors
title_full	Using apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors
title_fullStr	Using apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors
title_full_unstemmed	Using apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors
title_sort	using apelin-based synthetic notch receptors to detect angiogenesis and treat solid tumors
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/305d2282cec8462487328efffb5cd954
work_keys_str_mv	AT zhifuwang usingapelinbasedsyntheticnotchreceptorstodetectangiogenesisandtreatsolidtumors AT fanwang usingapelinbasedsyntheticnotchreceptorstodetectangiogenesisandtreatsolidtumors AT junjiezhong usingapelinbasedsyntheticnotchreceptorstodetectangiogenesisandtreatsolidtumors AT tongmingzhu usingapelinbasedsyntheticnotchreceptorstodetectangiogenesisandtreatsolidtumors AT yongtaozheng usingapelinbasedsyntheticnotchreceptorstodetectangiogenesisandtreatsolidtumors AT tongzhao usingapelinbasedsyntheticnotchreceptorstodetectangiogenesisandtreatsolidtumors AT qiangxie usingapelinbasedsyntheticnotchreceptorstodetectangiogenesisandtreatsolidtumors AT fukaima usingapelinbasedsyntheticnotchreceptorstodetectangiogenesisandtreatsolidtumors AT ronggangli usingapelinbasedsyntheticnotchreceptorstodetectangiogenesisandtreatsolidtumors AT qishengtang usingapelinbasedsyntheticnotchreceptorstodetectangiogenesisandtreatsolidtumors AT fengxu usingapelinbasedsyntheticnotchreceptorstodetectangiogenesisandtreatsolidtumors AT xueyingtian usingapelinbasedsyntheticnotchreceptorstodetectangiogenesisandtreatsolidtumors AT jianhongzhu usingapelinbasedsyntheticnotchreceptorstodetectangiogenesisandtreatsolidtumors
_version_	1718380603573796864

Using apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors

Ejemplares similares