Using apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors

Using apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors

Cellular markers of endothelial cell proliferation help identify the vasculature of tumours in homeostasis. Here, the authors report Apelin-based synthetic Notch (synNotch) receptors that can target Apj expressed on endothelium and stimulate the synNotch pathways upon Apj binding, and suggest this a...

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Autores principales: Zhifu Wang, Fan Wang, Junjie Zhong, Tongming Zhu, Yongtao Zheng, Tong Zhao, Qiang Xie, Fukai Ma, Ronggang Li, Qisheng Tang, Feng Xu, Xueying Tian, Jianhong Zhu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/305d2282cec8462487328efffb5cd954
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