Ribosomal Protein L23 Drives the Metastasis of Hepatocellular Carcinoma via Upregulating MMP9

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths globally. Tumor metastasis is one of the major causes of high mortality of HCC. Identifying underlying key factors contributing to invasion and metastasis is critical to understand the molecular mechanisms of HCC me...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Minli Yang, Yujiao Zhou, Haijun Deng, Hongzhong Zhou, Shengtao Cheng, Dapeng Zhang, Xin He, Li Mai, Yao Chen, Juan Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	RPL23 HCC metastasis RNA stability MMP9 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/305eebea10c7466eb6222026a1dd47dd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:305eebea10c7466eb6222026a1dd47dd
record_format	dspace
spelling	oai:doaj.org-article:305eebea10c7466eb6222026a1dd47dd2021-12-03T04:33:27ZRibosomal Protein L23 Drives the Metastasis of Hepatocellular Carcinoma via Upregulating MMP92234-943X10.3389/fonc.2021.779748https://doaj.org/article/305eebea10c7466eb6222026a1dd47dd2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.779748/fullhttps://doaj.org/toc/2234-943XHepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths globally. Tumor metastasis is one of the major causes of high mortality of HCC. Identifying underlying key factors contributing to invasion and metastasis is critical to understand the molecular mechanisms of HCC metastasis. Here, we identified RNA binding protein L23 (RPL23) as a tumor metastasis driver in HCC. RPL23 was significantly upregulated in HCC tissues compared to adjacent normal tissues, and closely related to poor clinical outcomes in HCC patients. RPL23 depletion inhibited HCC cell proliferation, migration and invasion, and distant metastasis. Mechanistically, RPL23 directly associated with 3’UTR of MMP9, therefore positively regulated MMP9 expression. In conclusion, we identified that RPL23 might play an important role in HCC metastasis in an MMP9-dependent manner and be a potential therapeutic target for HCC tumorigenesis and metastasis.Minli YangYujiao ZhouHaijun DengHongzhong ZhouShengtao ChengDapeng ZhangXin HeLi MaiYao ChenJuan ChenFrontiers Media S.A.articleRPL23HCCmetastasisRNA stabilityMMP9Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	RPL23 HCC metastasis RNA stability MMP9 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	RPL23 HCC metastasis RNA stability MMP9 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Minli Yang Yujiao Zhou Haijun Deng Hongzhong Zhou Shengtao Cheng Dapeng Zhang Xin He Li Mai Yao Chen Juan Chen Ribosomal Protein L23 Drives the Metastasis of Hepatocellular Carcinoma via Upregulating MMP9
description	Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths globally. Tumor metastasis is one of the major causes of high mortality of HCC. Identifying underlying key factors contributing to invasion and metastasis is critical to understand the molecular mechanisms of HCC metastasis. Here, we identified RNA binding protein L23 (RPL23) as a tumor metastasis driver in HCC. RPL23 was significantly upregulated in HCC tissues compared to adjacent normal tissues, and closely related to poor clinical outcomes in HCC patients. RPL23 depletion inhibited HCC cell proliferation, migration and invasion, and distant metastasis. Mechanistically, RPL23 directly associated with 3’UTR of MMP9, therefore positively regulated MMP9 expression. In conclusion, we identified that RPL23 might play an important role in HCC metastasis in an MMP9-dependent manner and be a potential therapeutic target for HCC tumorigenesis and metastasis.
format	article
author	Minli Yang Yujiao Zhou Haijun Deng Hongzhong Zhou Shengtao Cheng Dapeng Zhang Xin He Li Mai Yao Chen Juan Chen
author_facet	Minli Yang Yujiao Zhou Haijun Deng Hongzhong Zhou Shengtao Cheng Dapeng Zhang Xin He Li Mai Yao Chen Juan Chen
author_sort	Minli Yang
title	Ribosomal Protein L23 Drives the Metastasis of Hepatocellular Carcinoma via Upregulating MMP9
title_short	Ribosomal Protein L23 Drives the Metastasis of Hepatocellular Carcinoma via Upregulating MMP9
title_full	Ribosomal Protein L23 Drives the Metastasis of Hepatocellular Carcinoma via Upregulating MMP9
title_fullStr	Ribosomal Protein L23 Drives the Metastasis of Hepatocellular Carcinoma via Upregulating MMP9
title_full_unstemmed	Ribosomal Protein L23 Drives the Metastasis of Hepatocellular Carcinoma via Upregulating MMP9
title_sort	ribosomal protein l23 drives the metastasis of hepatocellular carcinoma via upregulating mmp9
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/305eebea10c7466eb6222026a1dd47dd
work_keys_str_mv	AT minliyang ribosomalproteinl23drivesthemetastasisofhepatocellularcarcinomaviaupregulatingmmp9 AT yujiaozhou ribosomalproteinl23drivesthemetastasisofhepatocellularcarcinomaviaupregulatingmmp9 AT haijundeng ribosomalproteinl23drivesthemetastasisofhepatocellularcarcinomaviaupregulatingmmp9 AT hongzhongzhou ribosomalproteinl23drivesthemetastasisofhepatocellularcarcinomaviaupregulatingmmp9 AT shengtaocheng ribosomalproteinl23drivesthemetastasisofhepatocellularcarcinomaviaupregulatingmmp9 AT dapengzhang ribosomalproteinl23drivesthemetastasisofhepatocellularcarcinomaviaupregulatingmmp9 AT xinhe ribosomalproteinl23drivesthemetastasisofhepatocellularcarcinomaviaupregulatingmmp9 AT limai ribosomalproteinl23drivesthemetastasisofhepatocellularcarcinomaviaupregulatingmmp9 AT yaochen ribosomalproteinl23drivesthemetastasisofhepatocellularcarcinomaviaupregulatingmmp9 AT juanchen ribosomalproteinl23drivesthemetastasisofhepatocellularcarcinomaviaupregulatingmmp9
_version_	1718373923244998656

Ribosomal Protein L23 Drives the Metastasis of Hepatocellular Carcinoma via Upregulating MMP9

Ejemplares similares