Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression

Background. Dengue virus (DENV) infection is the most common arboviral disease that affects tropical and subtropical regions. Based on the clinical hallmarks, the different severities of patients range from mild dengue fever (MDF) to severe dengue diseases (SDDs) and include dengue hemorrhagic fever...

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Autores principales:	Josephine Diony Nanda, Chiau-Jing Jung, Rahmat Dani Satria, Ming-Kai Jhan, Ting-Jing Shen, Po-Chun Tseng, Yung-Ting Wang, Tzong-Shiann Ho, Chiou-Feng Lin
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/30614651fdba4b30bbea58052353cb3a
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spelling	oai:doaj.org-article:30614651fdba4b30bbea58052353cb3a2021-11-08T02:36:57ZSerum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression2314-715610.1155/2021/7652569https://doaj.org/article/30614651fdba4b30bbea58052353cb3a2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7652569https://doaj.org/toc/2314-7156Background. Dengue virus (DENV) infection is the most common arboviral disease that affects tropical and subtropical regions. Based on the clinical hallmarks, the different severities of patients range from mild dengue fever (MDF) to severe dengue diseases (SDDs) and include dengue hemorrhagic fever or dengue shock syndrome. These are commonly associated with cytokine release syndrome (CRS). The types and levels of cytokines/chemokines, which are suppressed or enhanced, are varied, indicating CRS’s pathogenic and host defensive effects. Principal Finding. In this study, we created an integrated and precise multiplex panel of cytokine/chemokine assays based on our literature analysis to monitor dengue CRS. A 24-plex panel of cytokines/chemokines was evaluated to measure the plasma levels of targeting factors in dengue patients with an MDF and SDD diagnosis without or with comorbidities. As identified in sixteen kinds of cytokines/chemokines, ten were significantly (P<0.05) (10/16) increased, one was significantly (P<0.01) (1/16) decreased, and five were potentially (5/16) altered in all dengue patients (n=30) in the acute phase of disease onset. Compared to MDF, the levels of IL-8 (CXCL-8) and IL-18 in SDD were markedly (P<0.05) increased, accompanied by positively increased IL-6 and TNF-α and decreased IFN-γ and RANTES. With comorbidities, SDD significantly (P<0.01) portrayed elevated IL-18 accompanied by increased IL-6 and decreased IFN-α2 and IL-12. In addition, decreased platelets were significantly (P<0.05) associated with increased IL-18. Significance. These results demonstrate an efficient panel of dengue cytokine/chemokine assays used to explore the possible level of CRS during the acute phase of disease onset; also, we are the first to report the increase of IL-18 in severe dengue with comorbidity compared to severe dengue without comorbidity and mild dengue.Josephine Diony NandaChiau-Jing JungRahmat Dani SatriaMing-Kai JhanTing-Jing ShenPo-Chun TsengYung-Ting WangTzong-Shiann HoChiou-Feng LinHindawi LimitedarticleImmunologic diseases. AllergyRC581-607ENJournal of Immunology Research, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607
spellingShingle	Immunologic diseases. Allergy RC581-607 Josephine Diony Nanda Chiau-Jing Jung Rahmat Dani Satria Ming-Kai Jhan Ting-Jing Shen Po-Chun Tseng Yung-Ting Wang Tzong-Shiann Ho Chiou-Feng Lin Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression
description	Background. Dengue virus (DENV) infection is the most common arboviral disease that affects tropical and subtropical regions. Based on the clinical hallmarks, the different severities of patients range from mild dengue fever (MDF) to severe dengue diseases (SDDs) and include dengue hemorrhagic fever or dengue shock syndrome. These are commonly associated with cytokine release syndrome (CRS). The types and levels of cytokines/chemokines, which are suppressed or enhanced, are varied, indicating CRS’s pathogenic and host defensive effects. Principal Finding. In this study, we created an integrated and precise multiplex panel of cytokine/chemokine assays based on our literature analysis to monitor dengue CRS. A 24-plex panel of cytokines/chemokines was evaluated to measure the plasma levels of targeting factors in dengue patients with an MDF and SDD diagnosis without or with comorbidities. As identified in sixteen kinds of cytokines/chemokines, ten were significantly (P<0.05) (10/16) increased, one was significantly (P<0.01) (1/16) decreased, and five were potentially (5/16) altered in all dengue patients (n=30) in the acute phase of disease onset. Compared to MDF, the levels of IL-8 (CXCL-8) and IL-18 in SDD were markedly (P<0.05) increased, accompanied by positively increased IL-6 and TNF-α and decreased IFN-γ and RANTES. With comorbidities, SDD significantly (P<0.01) portrayed elevated IL-18 accompanied by increased IL-6 and decreased IFN-α2 and IL-12. In addition, decreased platelets were significantly (P<0.05) associated with increased IL-18. Significance. These results demonstrate an efficient panel of dengue cytokine/chemokine assays used to explore the possible level of CRS during the acute phase of disease onset; also, we are the first to report the increase of IL-18 in severe dengue with comorbidity compared to severe dengue without comorbidity and mild dengue.
format	article
author	Josephine Diony Nanda Chiau-Jing Jung Rahmat Dani Satria Ming-Kai Jhan Ting-Jing Shen Po-Chun Tseng Yung-Ting Wang Tzong-Shiann Ho Chiou-Feng Lin
author_facet	Josephine Diony Nanda Chiau-Jing Jung Rahmat Dani Satria Ming-Kai Jhan Ting-Jing Shen Po-Chun Tseng Yung-Ting Wang Tzong-Shiann Ho Chiou-Feng Lin
author_sort	Josephine Diony Nanda
title	Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression
title_short	Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression
title_full	Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression
title_fullStr	Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression
title_full_unstemmed	Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression
title_sort	serum il-18 is a potential biomarker for predicting severe dengue disease progression
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/30614651fdba4b30bbea58052353cb3a
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Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression

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