Clinicopathologic significance and race-specific prognostic association of MYB overexpression in ovarian cancer

Abstract Late diagnosis, unreliable prognostic assessment, and poorly-guided therapeutic planning result in dismal survival of ovarian cancer (OC) patients. Therefore, identifying novel functional biomarker(s) is highly desired for improved clinical management. MYB is an oncogenic transcription fact...

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Autores principales:	Orlandric Miree, Sanjeev Kumar Srivastava, Mohammad Aslam Khan, Fnu Sameeta, Srijan Acharya, Harrison Ndetan, Karan Pal Singh, Kate Louise Hertweck, Santanu Dasgupta, Luciana Madeira da Silva, Rodney Paul Rocconi, James Elliot Carter, Seema Singh, Ajay Pratap Singh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/30615822bfcd4ad6ba98457a8ab7c760
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spelling	oai:doaj.org-article:30615822bfcd4ad6ba98457a8ab7c7602021-12-02T17:13:27ZClinicopathologic significance and race-specific prognostic association of MYB overexpression in ovarian cancer10.1038/s41598-021-92352-32045-2322https://doaj.org/article/30615822bfcd4ad6ba98457a8ab7c7602021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92352-3https://doaj.org/toc/2045-2322Abstract Late diagnosis, unreliable prognostic assessment, and poorly-guided therapeutic planning result in dismal survival of ovarian cancer (OC) patients. Therefore, identifying novel functional biomarker(s) is highly desired for improved clinical management. MYB is an oncogenic transcription factor with emerging functional significance in OC. Here we examined its clinicopathologic significance by immunohistochemistry and TCGA/GTex data analyses. Aberrant MYB expression was detected in 94% of OC cases (n = 373), but not in the normal ovarian tissues (n = 23). MYB was overexpressed in all major epithelial OC histological subtypes exhibiting the highest incidence (~ 97%) and overall expression in serous and mucinous carcinomas. MYB expression correlated positively with tumor grades and stages. Moreover, MYB exhibited race-specific prognostic association. Moderate-to-high MYB levels were significantly associated with both poor overall- (p = 0.02) and progression-free (p = 0.02) survival in African American (AA), but not in the Caucasian American (CA) patients. Consistent with immunohistochemistry data, we observed significantly higher MYB transcripts in OC cases (n = 426) than normal ovary (n = 88). MYB transcripts were significantly higher in all epithelial OC subtypes, compared to normal, and its greater levels predicted poor survival in AA OC, but not CA OC, patients. Thus, MYB appears to be a useful clinical biomarker for prognostication, especially in AA patients.Orlandric MireeSanjeev Kumar SrivastavaMohammad Aslam KhanFnu SameetaSrijan AcharyaHarrison NdetanKaran Pal SinghKate Louise HertweckSantanu DasguptaLuciana Madeira da SilvaRodney Paul RocconiJames Elliot CarterSeema SinghAjay Pratap SinghNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Orlandric Miree Sanjeev Kumar Srivastava Mohammad Aslam Khan Fnu Sameeta Srijan Acharya Harrison Ndetan Karan Pal Singh Kate Louise Hertweck Santanu Dasgupta Luciana Madeira da Silva Rodney Paul Rocconi James Elliot Carter Seema Singh Ajay Pratap Singh Clinicopathologic significance and race-specific prognostic association of MYB overexpression in ovarian cancer
description	Abstract Late diagnosis, unreliable prognostic assessment, and poorly-guided therapeutic planning result in dismal survival of ovarian cancer (OC) patients. Therefore, identifying novel functional biomarker(s) is highly desired for improved clinical management. MYB is an oncogenic transcription factor with emerging functional significance in OC. Here we examined its clinicopathologic significance by immunohistochemistry and TCGA/GTex data analyses. Aberrant MYB expression was detected in 94% of OC cases (n = 373), but not in the normal ovarian tissues (n = 23). MYB was overexpressed in all major epithelial OC histological subtypes exhibiting the highest incidence (~ 97%) and overall expression in serous and mucinous carcinomas. MYB expression correlated positively with tumor grades and stages. Moreover, MYB exhibited race-specific prognostic association. Moderate-to-high MYB levels were significantly associated with both poor overall- (p = 0.02) and progression-free (p = 0.02) survival in African American (AA), but not in the Caucasian American (CA) patients. Consistent with immunohistochemistry data, we observed significantly higher MYB transcripts in OC cases (n = 426) than normal ovary (n = 88). MYB transcripts were significantly higher in all epithelial OC subtypes, compared to normal, and its greater levels predicted poor survival in AA OC, but not CA OC, patients. Thus, MYB appears to be a useful clinical biomarker for prognostication, especially in AA patients.
format	article
author	Orlandric Miree Sanjeev Kumar Srivastava Mohammad Aslam Khan Fnu Sameeta Srijan Acharya Harrison Ndetan Karan Pal Singh Kate Louise Hertweck Santanu Dasgupta Luciana Madeira da Silva Rodney Paul Rocconi James Elliot Carter Seema Singh Ajay Pratap Singh
author_facet	Orlandric Miree Sanjeev Kumar Srivastava Mohammad Aslam Khan Fnu Sameeta Srijan Acharya Harrison Ndetan Karan Pal Singh Kate Louise Hertweck Santanu Dasgupta Luciana Madeira da Silva Rodney Paul Rocconi James Elliot Carter Seema Singh Ajay Pratap Singh
author_sort	Orlandric Miree
title	Clinicopathologic significance and race-specific prognostic association of MYB overexpression in ovarian cancer
title_short	Clinicopathologic significance and race-specific prognostic association of MYB overexpression in ovarian cancer
title_full	Clinicopathologic significance and race-specific prognostic association of MYB overexpression in ovarian cancer
title_fullStr	Clinicopathologic significance and race-specific prognostic association of MYB overexpression in ovarian cancer
title_full_unstemmed	Clinicopathologic significance and race-specific prognostic association of MYB overexpression in ovarian cancer
title_sort	clinicopathologic significance and race-specific prognostic association of myb overexpression in ovarian cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/30615822bfcd4ad6ba98457a8ab7c760
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Clinicopathologic significance and race-specific prognostic association of MYB overexpression in ovarian cancer

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