What was I thinking? Eye-tracking experiments underscore the bias that architecture exerts on nuclear grading in prostate cancer.

We previously reported that nuclear grade assignment of prostate carcinomas is subject to a cognitive bias induced by the tumor architecture. Here, we asked whether this bias is mediated by the non-conscious selection of nuclei that "match the expectation" induced by the inadvertent glance...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dario Bombari, Braulio Mora, Stephan C Schaefer, Fred W Mast, Hans-Anton Lehr
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/30644182c74640298ed46900d77c7c19
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:30644182c74640298ed46900d77c7c19
record_format	dspace
spelling	oai:doaj.org-article:30644182c74640298ed46900d77c7c192021-11-18T07:16:54ZWhat was I thinking? Eye-tracking experiments underscore the bias that architecture exerts on nuclear grading in prostate cancer.1932-620310.1371/journal.pone.0038023https://doaj.org/article/30644182c74640298ed46900d77c7c192012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22666438/?tool=EBIhttps://doaj.org/toc/1932-6203We previously reported that nuclear grade assignment of prostate carcinomas is subject to a cognitive bias induced by the tumor architecture. Here, we asked whether this bias is mediated by the non-conscious selection of nuclei that "match the expectation" induced by the inadvertent glance at the tumor architecture. 20 pathologists were asked to grade nuclei in high power fields of 20 prostate carcinomas displayed on a computer screen. Unknown to the pathologists, each carcinoma was shown twice, once before a background of a low grade, tubule-rich carcinoma and once before the background of a high grade, solid carcinoma. Eye tracking allowed to identify which nuclei the pathologists fixated during the 8 second projection period. For all 20 pathologists, nuclear grade assignment was significantly biased by tumor architecture. Pathologists tended to fixate on bigger, darker, and more irregular nuclei when those were projected before kigh grade, solid carcinomas than before low grade, tubule-rich carcinomas (and vice versa). However, the morphometric differences of the selected nuclei accounted for only 11% of the architecture-induced bias, suggesting that it can only to a small part be explained by the unconscious fixation on nuclei that "match the expectation". In conclusion, selection of « matching nuclei » represents an unconscious effort to vindicate the gravitation of nuclear grades towards the tumor architecture.Dario BombariBraulio MoraStephan C SchaeferFred W MastHans-Anton LehrPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e38023 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dario Bombari Braulio Mora Stephan C Schaefer Fred W Mast Hans-Anton Lehr What was I thinking? Eye-tracking experiments underscore the bias that architecture exerts on nuclear grading in prostate cancer.
description	We previously reported that nuclear grade assignment of prostate carcinomas is subject to a cognitive bias induced by the tumor architecture. Here, we asked whether this bias is mediated by the non-conscious selection of nuclei that "match the expectation" induced by the inadvertent glance at the tumor architecture. 20 pathologists were asked to grade nuclei in high power fields of 20 prostate carcinomas displayed on a computer screen. Unknown to the pathologists, each carcinoma was shown twice, once before a background of a low grade, tubule-rich carcinoma and once before the background of a high grade, solid carcinoma. Eye tracking allowed to identify which nuclei the pathologists fixated during the 8 second projection period. For all 20 pathologists, nuclear grade assignment was significantly biased by tumor architecture. Pathologists tended to fixate on bigger, darker, and more irregular nuclei when those were projected before kigh grade, solid carcinomas than before low grade, tubule-rich carcinomas (and vice versa). However, the morphometric differences of the selected nuclei accounted for only 11% of the architecture-induced bias, suggesting that it can only to a small part be explained by the unconscious fixation on nuclei that "match the expectation". In conclusion, selection of « matching nuclei » represents an unconscious effort to vindicate the gravitation of nuclear grades towards the tumor architecture.
format	article
author	Dario Bombari Braulio Mora Stephan C Schaefer Fred W Mast Hans-Anton Lehr
author_facet	Dario Bombari Braulio Mora Stephan C Schaefer Fred W Mast Hans-Anton Lehr
author_sort	Dario Bombari
title	What was I thinking? Eye-tracking experiments underscore the bias that architecture exerts on nuclear grading in prostate cancer.
title_short	What was I thinking? Eye-tracking experiments underscore the bias that architecture exerts on nuclear grading in prostate cancer.
title_full	What was I thinking? Eye-tracking experiments underscore the bias that architecture exerts on nuclear grading in prostate cancer.
title_fullStr	What was I thinking? Eye-tracking experiments underscore the bias that architecture exerts on nuclear grading in prostate cancer.
title_full_unstemmed	What was I thinking? Eye-tracking experiments underscore the bias that architecture exerts on nuclear grading in prostate cancer.
title_sort	what was i thinking? eye-tracking experiments underscore the bias that architecture exerts on nuclear grading in prostate cancer.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/30644182c74640298ed46900d77c7c19
work_keys_str_mv	AT dariobombari whatwasithinkingeyetrackingexperimentsunderscorethebiasthatarchitectureexertsonnucleargradinginprostatecancer AT brauliomora whatwasithinkingeyetrackingexperimentsunderscorethebiasthatarchitectureexertsonnucleargradinginprostatecancer AT stephancschaefer whatwasithinkingeyetrackingexperimentsunderscorethebiasthatarchitectureexertsonnucleargradinginprostatecancer AT fredwmast whatwasithinkingeyetrackingexperimentsunderscorethebiasthatarchitectureexertsonnucleargradinginprostatecancer AT hansantonlehr whatwasithinkingeyetrackingexperimentsunderscorethebiasthatarchitectureexertsonnucleargradinginprostatecancer
_version_	1718423654523469824

What was I thinking? Eye-tracking experiments underscore the bias that architecture exerts on nuclear grading in prostate cancer.

Ejemplares similares