Association between Homocysteine Levels and All-cause Mortality: A Dose-Response Meta-Analysis of Prospective Studies

Abstract Plasma homocysteine (Hcy) levels may be associated with all-cause mortality risk. However, the results of this association are conflicting and the dose-response relationship between them has not been clearly defined. In this meta-analysis, we conducted a systematic literature search of the...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rui Fan, Aiping Zhang, Fade Zhong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3071264f492546818c4b111a14d4b986
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3071264f492546818c4b111a14d4b986
record_format	dspace
spelling	oai:doaj.org-article:3071264f492546818c4b111a14d4b9862021-12-02T15:06:11ZAssociation between Homocysteine Levels and All-cause Mortality: A Dose-Response Meta-Analysis of Prospective Studies10.1038/s41598-017-05205-32045-2322https://doaj.org/article/3071264f492546818c4b111a14d4b9862017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05205-3https://doaj.org/toc/2045-2322Abstract Plasma homocysteine (Hcy) levels may be associated with all-cause mortality risk. However, the results of this association are conflicting and the dose-response relationship between them has not been clearly defined. In this meta-analysis, we conducted a systematic literature search of the PubMed, Embase, Web of Science and Cochrane Library for the relevant articles dated up to February 2017. Pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs) were calculated to evaluate the estimates, and the dose-response relationship was estimated using a restricted cubic spline model. Eleven prospective studies (4,110 deaths among 27,737 individuals) were included. The summary RR of all-cause mortality for the highest Hcy category vs. the lowest Hcy category was 1.80 (95% CI: 1.51, 2.14) with the random effects model. In dose-response meta-analysis, Hcy levels were significantly associated with all-cause mortality risk in a linear fashion (p nonlinearity = 0.255), and the risk of all-cause mortality increased by 33.6% for each 5 µmol/L increase in Hcy levels (RR = 1.336, 95% CI: 1.254–1.422, p < 0.001). Findings from this dose-response meta-analysis suggest that Hcy levels are linearly and positively associated with risk of all-cause mortality.Rui FanAiping ZhangFade ZhongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rui Fan Aiping Zhang Fade Zhong Association between Homocysteine Levels and All-cause Mortality: A Dose-Response Meta-Analysis of Prospective Studies
description	Abstract Plasma homocysteine (Hcy) levels may be associated with all-cause mortality risk. However, the results of this association are conflicting and the dose-response relationship between them has not been clearly defined. In this meta-analysis, we conducted a systematic literature search of the PubMed, Embase, Web of Science and Cochrane Library for the relevant articles dated up to February 2017. Pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs) were calculated to evaluate the estimates, and the dose-response relationship was estimated using a restricted cubic spline model. Eleven prospective studies (4,110 deaths among 27,737 individuals) were included. The summary RR of all-cause mortality for the highest Hcy category vs. the lowest Hcy category was 1.80 (95% CI: 1.51, 2.14) with the random effects model. In dose-response meta-analysis, Hcy levels were significantly associated with all-cause mortality risk in a linear fashion (p nonlinearity = 0.255), and the risk of all-cause mortality increased by 33.6% for each 5 µmol/L increase in Hcy levels (RR = 1.336, 95% CI: 1.254–1.422, p < 0.001). Findings from this dose-response meta-analysis suggest that Hcy levels are linearly and positively associated with risk of all-cause mortality.
format	article
author	Rui Fan Aiping Zhang Fade Zhong
author_facet	Rui Fan Aiping Zhang Fade Zhong
author_sort	Rui Fan
title	Association between Homocysteine Levels and All-cause Mortality: A Dose-Response Meta-Analysis of Prospective Studies
title_short	Association between Homocysteine Levels and All-cause Mortality: A Dose-Response Meta-Analysis of Prospective Studies
title_full	Association between Homocysteine Levels and All-cause Mortality: A Dose-Response Meta-Analysis of Prospective Studies
title_fullStr	Association between Homocysteine Levels and All-cause Mortality: A Dose-Response Meta-Analysis of Prospective Studies
title_full_unstemmed	Association between Homocysteine Levels and All-cause Mortality: A Dose-Response Meta-Analysis of Prospective Studies
title_sort	association between homocysteine levels and all-cause mortality: a dose-response meta-analysis of prospective studies
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3071264f492546818c4b111a14d4b986
work_keys_str_mv	AT ruifan associationbetweenhomocysteinelevelsandallcausemortalityadoseresponsemetaanalysisofprospectivestudies AT aipingzhang associationbetweenhomocysteinelevelsandallcausemortalityadoseresponsemetaanalysisofprospectivestudies AT fadezhong associationbetweenhomocysteinelevelsandallcausemortalityadoseresponsemetaanalysisofprospectivestudies
_version_	1718388570882834432

Association between Homocysteine Levels and All-cause Mortality: A Dose-Response Meta-Analysis of Prospective Studies

Ejemplares similares