IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners

Herpes simplex virus-1 (HSV-1) suppresses the induction of interferon to evade antiviral immunity. Here, Wang et al. show that during HSV-1 infection, IL-36 increases cellular sensitivity to interferon through induction of IRF1 and the interferon receptor.

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Detalles Bibliográficos
Autores principales:	Peng Wang, Ana M. Gamero, Liselotte E. Jensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3073fa03cb584d1194574e47cd64e772
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spelling	oai:doaj.org-article:3073fa03cb584d1194574e47cd64e7722021-12-02T15:35:13ZIL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners10.1038/s41467-019-12318-y2041-1723https://doaj.org/article/3073fa03cb584d1194574e47cd64e7722019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12318-yhttps://doaj.org/toc/2041-1723Herpes simplex virus-1 (HSV-1) suppresses the induction of interferon to evade antiviral immunity. Here, Wang et al. show that during HSV-1 infection, IL-36 increases cellular sensitivity to interferon through induction of IRF1 and the interferon receptor.Peng WangAna M. GameroLiselotte E. JensenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peng Wang Ana M. Gamero Liselotte E. Jensen IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners
description	Herpes simplex virus-1 (HSV-1) suppresses the induction of interferon to evade antiviral immunity. Here, Wang et al. show that during HSV-1 infection, IL-36 increases cellular sensitivity to interferon through induction of IRF1 and the interferon receptor.
format	article
author	Peng Wang Ana M. Gamero Liselotte E. Jensen
author_facet	Peng Wang Ana M. Gamero Liselotte E. Jensen
author_sort	Peng Wang
title	IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners
title_short	IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners
title_full	IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners
title_fullStr	IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners
title_full_unstemmed	IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners
title_sort	il-36 promotes anti-viral immunity by boosting sensitivity to ifn-α/β in irf1 dependent and independent manners
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3073fa03cb584d1194574e47cd64e772
work_keys_str_mv	AT pengwang il36promotesantiviralimmunitybyboostingsensitivitytoifnabinirf1dependentandindependentmanners AT anamgamero il36promotesantiviralimmunitybyboostingsensitivitytoifnabinirf1dependentandindependentmanners AT liselotteejensen il36promotesantiviralimmunitybyboostingsensitivitytoifnabinirf1dependentandindependentmanners
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IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners

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