Speckle-tracking echocardiography in 3D mode in assessing the deformation of the myocardium and identifying subclinical cardiotoxicity during chemotherapy in breast cancer patients with arterial hypertension

Aim.To study the possibilities of speckle-tracking echocardiography (STE) in 3D mode in assessing the strain of the myocardium and identifying subclinical cardiotoxicity during anthracycline-containing chemotherapy in breast cancer patients with arterial hypertension. Materials and methods.The st...

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Autores principales:	Ani A. Avalyan, Marina A. Saidova, Elena V. Oshchepkova, Irina E. Chazova
Formato:	article
Lenguaje:	RU
Publicado:	IP Morozov P.V. 2020
Materias:	speckle-tracking echocardiography in three-dimensional mode cardiotoxicity chemotherapy breast cancer arterial hypertension Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/307480e69e1c4686a0808afbf982fd88
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spelling	oai:doaj.org-article:307480e69e1c4686a0808afbf982fd882021-11-30T16:09:16ZSpeckle-tracking echocardiography in 3D mode in assessing the deformation of the myocardium and identifying subclinical cardiotoxicity during chemotherapy in breast cancer patients with arterial hypertension2075-082X2542-218910.26442/2075082X.2020.3.200334https://doaj.org/article/307480e69e1c4686a0808afbf982fd882020-10-01T00:00:00Zhttps://syst-hypertension.ru/2075-082X/article/viewFile/43901/pdfhttps://doaj.org/toc/2075-082Xhttps://doaj.org/toc/2542-2189Aim.To study the possibilities of speckle-tracking echocardiography (STE) in 3D mode in assessing the strain of the myocardium and identifying subclinical cardiotoxicity during anthracycline-containing chemotherapy in breast cancer patients with arterial hypertension. Materials and methods.The study included 47 patients with triple negative breast cancer (BC) with AH and normotension. All patients underwent transthoracic echocardiography with an assessment of the left ventricular (LV) ejection fraction, also used STE in three-dimensional mode with an assessment of global longitudinal (GLS), circular (GCS), radial (GRS) strain and a new strain parameter strain area (GAS). Results.In patients with BC for a more accurate assessment of LV systolic function, it is advisable to use 3D echocardiography. In BC patients with AH, the initial parameters of LV strain were statistically significantly worse than in patients with normotension and further deterioration was observed after chemotherapy. To determine the sensitivity and specificity of the strain parameters from the 3D-STE data, an ROC analysis was performed. The most diagnostically significant parameter of strain, as a marker of cardiotoxicity, was the global area strain (GAS), which with a cut-off value -14.0% showed a sensitivity equal to 81.5% and a specificity of 73.3%, but the value this parameter of LV deformation requires further study. Conclusion.In BC patients with AH and normotension it is advisable to use the STE in 3D mode to analyze the strain and systolic function of the LV during antitumor treatment. The method is promising for identifying subclinical cardiotoxicity, but further research is needed to develop diagnostic criteria.Ani A. AvalyanMarina A. SaidovaElena V. OshchepkovaIrina E. ChazovaIP Morozov P.V.articlespeckle-tracking echocardiography in three-dimensional modecardiotoxicitychemotherapybreast cancerarterial hypertensionDiseases of the circulatory (Cardiovascular) systemRC666-701RUСистемные гипертензии, Vol 17, Iss 3, Pp 42-47 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	speckle-tracking echocardiography in three-dimensional mode cardiotoxicity chemotherapy breast cancer arterial hypertension Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	speckle-tracking echocardiography in three-dimensional mode cardiotoxicity chemotherapy breast cancer arterial hypertension Diseases of the circulatory (Cardiovascular) system RC666-701 Ani A. Avalyan Marina A. Saidova Elena V. Oshchepkova Irina E. Chazova Speckle-tracking echocardiography in 3D mode in assessing the deformation of the myocardium and identifying subclinical cardiotoxicity during chemotherapy in breast cancer patients with arterial hypertension
description	Aim.To study the possibilities of speckle-tracking echocardiography (STE) in 3D mode in assessing the strain of the myocardium and identifying subclinical cardiotoxicity during anthracycline-containing chemotherapy in breast cancer patients with arterial hypertension. Materials and methods.The study included 47 patients with triple negative breast cancer (BC) with AH and normotension. All patients underwent transthoracic echocardiography with an assessment of the left ventricular (LV) ejection fraction, also used STE in three-dimensional mode with an assessment of global longitudinal (GLS), circular (GCS), radial (GRS) strain and a new strain parameter strain area (GAS). Results.In patients with BC for a more accurate assessment of LV systolic function, it is advisable to use 3D echocardiography. In BC patients with AH, the initial parameters of LV strain were statistically significantly worse than in patients with normotension and further deterioration was observed after chemotherapy. To determine the sensitivity and specificity of the strain parameters from the 3D-STE data, an ROC analysis was performed. The most diagnostically significant parameter of strain, as a marker of cardiotoxicity, was the global area strain (GAS), which with a cut-off value -14.0% showed a sensitivity equal to 81.5% and a specificity of 73.3%, but the value this parameter of LV deformation requires further study. Conclusion.In BC patients with AH and normotension it is advisable to use the STE in 3D mode to analyze the strain and systolic function of the LV during antitumor treatment. The method is promising for identifying subclinical cardiotoxicity, but further research is needed to develop diagnostic criteria.
format	article
author	Ani A. Avalyan Marina A. Saidova Elena V. Oshchepkova Irina E. Chazova
author_facet	Ani A. Avalyan Marina A. Saidova Elena V. Oshchepkova Irina E. Chazova
author_sort	Ani A. Avalyan
title	Speckle-tracking echocardiography in 3D mode in assessing the deformation of the myocardium and identifying subclinical cardiotoxicity during chemotherapy in breast cancer patients with arterial hypertension
title_short	Speckle-tracking echocardiography in 3D mode in assessing the deformation of the myocardium and identifying subclinical cardiotoxicity during chemotherapy in breast cancer patients with arterial hypertension
title_full	Speckle-tracking echocardiography in 3D mode in assessing the deformation of the myocardium and identifying subclinical cardiotoxicity during chemotherapy in breast cancer patients with arterial hypertension
title_fullStr	Speckle-tracking echocardiography in 3D mode in assessing the deformation of the myocardium and identifying subclinical cardiotoxicity during chemotherapy in breast cancer patients with arterial hypertension
title_full_unstemmed	Speckle-tracking echocardiography in 3D mode in assessing the deformation of the myocardium and identifying subclinical cardiotoxicity during chemotherapy in breast cancer patients with arterial hypertension
title_sort	speckle-tracking echocardiography in 3d mode in assessing the deformation of the myocardium and identifying subclinical cardiotoxicity during chemotherapy in breast cancer patients with arterial hypertension
publisher	IP Morozov P.V.
publishDate	2020
url	https://doaj.org/article/307480e69e1c4686a0808afbf982fd88
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Speckle-tracking echocardiography in 3D mode in assessing the deformation of the myocardium and identifying subclinical cardiotoxicity during chemotherapy in breast cancer patients with arterial hypertension

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