Offspring sex and parental health and mortality

Abstract Increased mortality has been observed in mothers and fathers with male offspring but little is known regarding specific diseases. In a register linkage we linked women born 1925–1954 having survived to age 50 (n = 661,031) to offspring and fathers (n = 691,124). Three approaches were used:...

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Autores principales:	Øyvind Næss, Laust H. Mortensen, Åse Vikanes, George Davey Smith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/30769256218d4599ab72d92539894134
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spelling	oai:doaj.org-article:30769256218d4599ab72d925398941342021-12-02T11:53:07ZOffspring sex and parental health and mortality10.1038/s41598-017-05161-y2045-2322https://doaj.org/article/30769256218d4599ab72d925398941342017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05161-yhttps://doaj.org/toc/2045-2322Abstract Increased mortality has been observed in mothers and fathers with male offspring but little is known regarding specific diseases. In a register linkage we linked women born 1925–1954 having survived to age 50 (n = 661,031) to offspring and fathers (n = 691,124). Three approaches were used: 1) number of total boy and girl offspring, 2) sex of the first and second offspring and 3) proportion of boys to total number of offspring. A sub-cohort (n = 50,736 mothers, n = 44,794 fathers) from survey data was analysed for risk factors. Mothers had increased risk of total and cardiovascular mortality that was consistent across approaches: cardiovascular mortality of 1.07 (95% CI: 1.03–1.11) per boy (approach 2), 1.04 (1.01–1.07) if the first offspring was a boy, and 1.06 (1.01–1.10) if the first two offspring were boys (approach 3). We found that sex of offspring was not associated with total or cardiovascular mortality in fathers. For other diseases or risk factors no robust associations were seen in mothers or fathers. Increased cardiovascular risk in mothers having male offspring suggests a maternal disease specific mechanism. The lack of consistent associations on measured risk factors could suggest other biological pathways than those studied play a role in generating this additional cardiovascular risk.Øyvind NæssLaust H. MortensenÅse VikanesGeorge Davey SmithNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Øyvind Næss Laust H. Mortensen Åse Vikanes George Davey Smith Offspring sex and parental health and mortality
description	Abstract Increased mortality has been observed in mothers and fathers with male offspring but little is known regarding specific diseases. In a register linkage we linked women born 1925–1954 having survived to age 50 (n = 661,031) to offspring and fathers (n = 691,124). Three approaches were used: 1) number of total boy and girl offspring, 2) sex of the first and second offspring and 3) proportion of boys to total number of offspring. A sub-cohort (n = 50,736 mothers, n = 44,794 fathers) from survey data was analysed for risk factors. Mothers had increased risk of total and cardiovascular mortality that was consistent across approaches: cardiovascular mortality of 1.07 (95% CI: 1.03–1.11) per boy (approach 2), 1.04 (1.01–1.07) if the first offspring was a boy, and 1.06 (1.01–1.10) if the first two offspring were boys (approach 3). We found that sex of offspring was not associated with total or cardiovascular mortality in fathers. For other diseases or risk factors no robust associations were seen in mothers or fathers. Increased cardiovascular risk in mothers having male offspring suggests a maternal disease specific mechanism. The lack of consistent associations on measured risk factors could suggest other biological pathways than those studied play a role in generating this additional cardiovascular risk.
format	article
author	Øyvind Næss Laust H. Mortensen Åse Vikanes George Davey Smith
author_facet	Øyvind Næss Laust H. Mortensen Åse Vikanes George Davey Smith
author_sort	Øyvind Næss
title	Offspring sex and parental health and mortality
title_short	Offspring sex and parental health and mortality
title_full	Offspring sex and parental health and mortality
title_fullStr	Offspring sex and parental health and mortality
title_full_unstemmed	Offspring sex and parental health and mortality
title_sort	offspring sex and parental health and mortality
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/30769256218d4599ab72d92539894134
work_keys_str_mv	AT øyvindnæss offspringsexandparentalhealthandmortality AT lausthmortensen offspringsexandparentalhealthandmortality AT asevikanes offspringsexandparentalhealthandmortality AT georgedaveysmith offspringsexandparentalhealthandmortality
_version_	1718394858082664448

Offspring sex and parental health and mortality

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