Clinical manifestations and typing of drug-induced liver injury

Drug-induced liver injury (DILI) is one of the most common and severe adverse drug reactions in humans, which may lead to liver failure and even death in some patients. Liver injury caused by different drugs has various clinical manifestations and severities, and most patients with DILI have no symp...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	YANG Wanna
Formato:	article
Lenguaje:	ZH
Publicado:	Editorial Department of Journal of Clinical Hepatology 2021
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/307987fafbd14a5289bbdc593162453e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:307987fafbd14a5289bbdc593162453e
record_format	dspace
spelling	oai:doaj.org-article:307987fafbd14a5289bbdc593162453e2021-11-17T10:36:29ZClinical manifestations and typing of drug-induced liver injury1001-5256https://doaj.org/article/307987fafbd14a5289bbdc593162453e2021-11-01T00:00:00Zhttp://www.lcgdbzz.org/cn/article/doi/10.3969/j.issn.1001-5256.2021.11.004https://doaj.org/toc/1001-5256Drug-induced liver injury (DILI) is one of the most common and severe adverse drug reactions in humans, which may lead to liver failure and even death in some patients. Liver injury caused by different drugs has various clinical manifestations and severities, and most patients with DILI have no symptoms or have mild symptoms. There are various typing methods for DILI based on clinical features, course of disease, and pathogenesis. According to the R value, DILI can be classified into hepatocellular injury type (R ≥5), cholestasis type (R ≤2), and mixed type (2 ＜R ＜5); according to the course of the disease, DILI can be classified into acute DILI and chronic DILI; according to the pathogenesis, DILI can be classified into intrinsic DILI, idiosyncratic DILI, and indirect DILI. A comprehensive understanding of the clinical manifestations and typing methods of DILI helps to reveal its pathogenesis and perform diagnosis and treatment in a timely manner.YANG WannaEditorial Department of Journal of Clinical HepatologyarticleDiseases of the digestive system. GastroenterologyRC799-869ZHLinchuang Gandanbing Zazhi, Vol 37, Iss 11, Pp 2525-2529 (2021)
institution	DOAJ
collection	DOAJ
language	ZH
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 YANG Wanna Clinical manifestations and typing of drug-induced liver injury
description	Drug-induced liver injury (DILI) is one of the most common and severe adverse drug reactions in humans, which may lead to liver failure and even death in some patients. Liver injury caused by different drugs has various clinical manifestations and severities, and most patients with DILI have no symptoms or have mild symptoms. There are various typing methods for DILI based on clinical features, course of disease, and pathogenesis. According to the R value, DILI can be classified into hepatocellular injury type (R ≥5), cholestasis type (R ≤2), and mixed type (2 ＜R ＜5); according to the course of the disease, DILI can be classified into acute DILI and chronic DILI; according to the pathogenesis, DILI can be classified into intrinsic DILI, idiosyncratic DILI, and indirect DILI. A comprehensive understanding of the clinical manifestations and typing methods of DILI helps to reveal its pathogenesis and perform diagnosis and treatment in a timely manner.
format	article
author	YANG Wanna
author_facet	YANG Wanna
author_sort	YANG Wanna
title	Clinical manifestations and typing of drug-induced liver injury
title_short	Clinical manifestations and typing of drug-induced liver injury
title_full	Clinical manifestations and typing of drug-induced liver injury
title_fullStr	Clinical manifestations and typing of drug-induced liver injury
title_full_unstemmed	Clinical manifestations and typing of drug-induced liver injury
title_sort	clinical manifestations and typing of drug-induced liver injury
publisher	Editorial Department of Journal of Clinical Hepatology
publishDate	2021
url	https://doaj.org/article/307987fafbd14a5289bbdc593162453e
work_keys_str_mv	AT yangwanna clinicalmanifestationsandtypingofdruginducedliverinjury
_version_	1718425600745537536

Clinical manifestations and typing of drug-induced liver injury

Ejemplares similares