Effects of FGFR4 G388R, V10I polymorphisms on the likelihood of cancer

Abstract The correlation between G388R or V10I polymorphisms of fibroblast growth factor receptor (FGFR) 4 gene and the risk of carcinoma has been investigated previously, but the results are contradictory. Odds ratios (ORs) with 95% confidence intervals (95%CIs), in silico tools, and immunohistoche...

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Autores principales:	Tao Peng, Yangyang Sun, Zhiwei Lv, Ze Zhang, Quanxin Su, Hao Wu, Wei Zhang, Wei Yuan, Li Zuo, Li Shi, Li-Feng Zhang, Xiaoli Zhou, Yuanyuan Mi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/30858f3b1d75450190bcfcc79fa4196c
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spelling	oai:doaj.org-article:30858f3b1d75450190bcfcc79fa4196c2021-12-02T14:01:37ZEffects of FGFR4 G388R, V10I polymorphisms on the likelihood of cancer10.1038/s41598-020-80146-y2045-2322https://doaj.org/article/30858f3b1d75450190bcfcc79fa4196c2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80146-yhttps://doaj.org/toc/2045-2322Abstract The correlation between G388R or V10I polymorphisms of fibroblast growth factor receptor (FGFR) 4 gene and the risk of carcinoma has been investigated previously, but the results are contradictory. Odds ratios (ORs) with 95% confidence intervals (95%CIs), in silico tools, and immunohistochemical staining (IHS) were adopted to assess the association. In total, 13,793 cancer patients and 16,179 controls were evaluated in our pooled analysis. Summarization of all the studies showed that G388R polymorphism is associated with elevated susceptibility to cancer under homozygous comparison (OR = 1.21, 95%CI = 1.03–1.43, P = 0.020) and a recessive genetic model (OR = 1.21, 95%CI = 1.04–1.41, P = 0.012). In the stratification analysis by cancer type and ethnicity, similar findings were indicated for prostate cancer, breast cancer, and individuals of Asian descendant. Polyphen2 bioinformatics analysis showed that the G388R mutation is predicted to damage the protein function of FGFR4. IHS analysis indicated that FGFR4 expression is increased in advanced prostate cancer. These findings may guide personalized treatment of certain types of cancers. Up-regulation of FGFR4 may be related to a poor prognosis in prostate cancer.Tao PengYangyang SunZhiwei LvZe ZhangQuanxin SuHao WuWei ZhangWei YuanLi ZuoLi ShiLi-Feng ZhangXiaoli ZhouYuanyuan MiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tao Peng Yangyang Sun Zhiwei Lv Ze Zhang Quanxin Su Hao Wu Wei Zhang Wei Yuan Li Zuo Li Shi Li-Feng Zhang Xiaoli Zhou Yuanyuan Mi Effects of FGFR4 G388R, V10I polymorphisms on the likelihood of cancer
description	Abstract The correlation between G388R or V10I polymorphisms of fibroblast growth factor receptor (FGFR) 4 gene and the risk of carcinoma has been investigated previously, but the results are contradictory. Odds ratios (ORs) with 95% confidence intervals (95%CIs), in silico tools, and immunohistochemical staining (IHS) were adopted to assess the association. In total, 13,793 cancer patients and 16,179 controls were evaluated in our pooled analysis. Summarization of all the studies showed that G388R polymorphism is associated with elevated susceptibility to cancer under homozygous comparison (OR = 1.21, 95%CI = 1.03–1.43, P = 0.020) and a recessive genetic model (OR = 1.21, 95%CI = 1.04–1.41, P = 0.012). In the stratification analysis by cancer type and ethnicity, similar findings were indicated for prostate cancer, breast cancer, and individuals of Asian descendant. Polyphen2 bioinformatics analysis showed that the G388R mutation is predicted to damage the protein function of FGFR4. IHS analysis indicated that FGFR4 expression is increased in advanced prostate cancer. These findings may guide personalized treatment of certain types of cancers. Up-regulation of FGFR4 may be related to a poor prognosis in prostate cancer.
format	article
author	Tao Peng Yangyang Sun Zhiwei Lv Ze Zhang Quanxin Su Hao Wu Wei Zhang Wei Yuan Li Zuo Li Shi Li-Feng Zhang Xiaoli Zhou Yuanyuan Mi
author_facet	Tao Peng Yangyang Sun Zhiwei Lv Ze Zhang Quanxin Su Hao Wu Wei Zhang Wei Yuan Li Zuo Li Shi Li-Feng Zhang Xiaoli Zhou Yuanyuan Mi
author_sort	Tao Peng
title	Effects of FGFR4 G388R, V10I polymorphisms on the likelihood of cancer
title_short	Effects of FGFR4 G388R, V10I polymorphisms on the likelihood of cancer
title_full	Effects of FGFR4 G388R, V10I polymorphisms on the likelihood of cancer
title_fullStr	Effects of FGFR4 G388R, V10I polymorphisms on the likelihood of cancer
title_full_unstemmed	Effects of FGFR4 G388R, V10I polymorphisms on the likelihood of cancer
title_sort	effects of fgfr4 g388r, v10i polymorphisms on the likelihood of cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/30858f3b1d75450190bcfcc79fa4196c
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Effects of FGFR4 G388R, V10I polymorphisms on the likelihood of cancer

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