Association between depression and the risk of Alzheimer’s disease using the Korean National Health Insurance Service-Elderly Cohort

Abstract In this cohort study, we assessed the association between depression and the risk of Alzheimer’s disease from data obtained from the 2002 to 2013 Korean National Health Insurance Service-Elderly Cohort Database, which accounts for 10% of the South Korean population aged > 60 years. A tot...

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Autores principales:	Hyunkyu Kim, Wonjeong Jeong, Junhyun Kwon, Youseok Kim, Eun-Cheol Park, Sung-In Jang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/30864208414f40998e44b9011eddef09
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spelling	oai:doaj.org-article:30864208414f40998e44b9011eddef092021-11-21T12:25:17ZAssociation between depression and the risk of Alzheimer’s disease using the Korean National Health Insurance Service-Elderly Cohort10.1038/s41598-021-02201-62045-2322https://doaj.org/article/30864208414f40998e44b9011eddef092021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02201-6https://doaj.org/toc/2045-2322Abstract In this cohort study, we assessed the association between depression and the risk of Alzheimer’s disease from data obtained from the 2002 to 2013 Korean National Health Insurance Service-Elderly Cohort Database, which accounts for 10% of the South Korean population aged > 60 years. A total 518,466 patients were included in the analysis and followed up, unless they were excluded due to death or migration. Patients who sought treatment for depression or dementia within 1 year of the washout period and who were diagnosed with dementia within the 1-year period of the diagnosis of depression were excluded from the study. The risk of dementia was analysed using Cox proportional hazards models. Patients with a history of depression during the follow-up period were at a higher risk of Alzheimer’s disease than those without a history of depression (HR 3.35, CI 3.27–3.42). The severe-depression group exhibited the highest risk of Alzheimer’s disease (HR 4.41, CI 4.04–4.81), while the mild-depression group exhibited a relatively lower risk of Alzheimer’s disease (HR 3.31, CI 3.16–3.47). The risk of Alzheimer’s disease was associated with depression history and an increased severity of depression increased the risk of Alzheimer’s disease.Hyunkyu KimWonjeong JeongJunhyun KwonYouseok KimEun-Cheol ParkSung-In JangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyunkyu Kim Wonjeong Jeong Junhyun Kwon Youseok Kim Eun-Cheol Park Sung-In Jang Association between depression and the risk of Alzheimer’s disease using the Korean National Health Insurance Service-Elderly Cohort
description	Abstract In this cohort study, we assessed the association between depression and the risk of Alzheimer’s disease from data obtained from the 2002 to 2013 Korean National Health Insurance Service-Elderly Cohort Database, which accounts for 10% of the South Korean population aged > 60 years. A total 518,466 patients were included in the analysis and followed up, unless they were excluded due to death or migration. Patients who sought treatment for depression or dementia within 1 year of the washout period and who were diagnosed with dementia within the 1-year period of the diagnosis of depression were excluded from the study. The risk of dementia was analysed using Cox proportional hazards models. Patients with a history of depression during the follow-up period were at a higher risk of Alzheimer’s disease than those without a history of depression (HR 3.35, CI 3.27–3.42). The severe-depression group exhibited the highest risk of Alzheimer’s disease (HR 4.41, CI 4.04–4.81), while the mild-depression group exhibited a relatively lower risk of Alzheimer’s disease (HR 3.31, CI 3.16–3.47). The risk of Alzheimer’s disease was associated with depression history and an increased severity of depression increased the risk of Alzheimer’s disease.
format	article
author	Hyunkyu Kim Wonjeong Jeong Junhyun Kwon Youseok Kim Eun-Cheol Park Sung-In Jang
author_facet	Hyunkyu Kim Wonjeong Jeong Junhyun Kwon Youseok Kim Eun-Cheol Park Sung-In Jang
author_sort	Hyunkyu Kim
title	Association between depression and the risk of Alzheimer’s disease using the Korean National Health Insurance Service-Elderly Cohort
title_short	Association between depression and the risk of Alzheimer’s disease using the Korean National Health Insurance Service-Elderly Cohort
title_full	Association between depression and the risk of Alzheimer’s disease using the Korean National Health Insurance Service-Elderly Cohort
title_fullStr	Association between depression and the risk of Alzheimer’s disease using the Korean National Health Insurance Service-Elderly Cohort
title_full_unstemmed	Association between depression and the risk of Alzheimer’s disease using the Korean National Health Insurance Service-Elderly Cohort
title_sort	association between depression and the risk of alzheimer’s disease using the korean national health insurance service-elderly cohort
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/30864208414f40998e44b9011eddef09
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Association between depression and the risk of Alzheimer’s disease using the Korean National Health Insurance Service-Elderly Cohort

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