Intrapleural use of urokinase and DNase in pleural infections managed with repeated thoracentesis: A comparative cohort study.

<h4>Introduction</h4>Evacuation of infected fluid in pleural infections is essential. To date, the use of an intrapleural fibrinolytic agent such as urokinase and DNase has not yet been assessed in infections managed by repeated therapeutic thoracentesis (RTT).<h4>Methods</h4>...

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Autores principales: David Luque Paz, Betsega Bayeh, Pierre Chauvin, Florence Poizeau, Mathieu Lederlin, Mallorie Kerjouan, Charles Lefevre, Bertrand de Latour, Julien Letheulle, Pierre Tattevin, Stéphane Jouneau
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Publicado: Public Library of Science (PLoS) 2021
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spelling oai:doaj.org-article:30887be71f8b4511958e8c38224f47f62021-12-02T20:06:11ZIntrapleural use of urokinase and DNase in pleural infections managed with repeated thoracentesis: A comparative cohort study.1932-620310.1371/journal.pone.0257339https://doaj.org/article/30887be71f8b4511958e8c38224f47f62021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257339https://doaj.org/toc/1932-6203<h4>Introduction</h4>Evacuation of infected fluid in pleural infections is essential. To date, the use of an intrapleural fibrinolytic agent such as urokinase and DNase has not yet been assessed in infections managed by repeated therapeutic thoracentesis (RTT).<h4>Methods</h4>We performed a retrospective comparative study of two successive cohorts of consecutive patients with pleural infections from 2001 to 2018. Between 2001 and 2010, patients had RTT with intrapleural urokinase (RTT-U). After 2011, patients received intrapleural urokinase and DNase with RTT (RTT-UD). Data were collected through a standardized questionnaire.<h4>Results</h4>One hundred and thirty-three patients were included: 93 were men and the mean age was 59 years (standard deviation 17.2). Eighty-one patients were treated with a combination of intrapleural urokinase and DNase, and 52 were treated with intrapleural urokinase only. In the RTT-UD, RTT failure occurred in 14 patients (17%) compared to 10 (19%) in the RTT-U group (P = 0.82). There was no difference between the two groups in intensive care unit admission, surgical referrals or in-hospital mortality. RTT-UD was associated with faster time to apyrexia (aOR = 0.51, 95%CI [0.37-0.72]), a reduced length of hospital stay (aOR = 0.61, 95%CI [0.52-0.73]) and a higher volume of total pleural fluid retrieved (aOR = 1.38, 95%CI [1.02-1.88]). Complications were rare with only one hemothorax in the RTT-UD group and no pneumothorax requiring drainage in either group.<h4>Conclusion</h4>Compared to urokinase only, intrapleural use of urokinase and DNase in RTT was associated with quicker defervescence, shorter hospital stay and increased volumes of pleural fluid drained. Randomized controlled trials evaluating urokinase and DNase with RTT technique would be required to confirm these results.David Luque PazBetsega BayehPierre ChauvinFlorence PoizeauMathieu LederlinMallorie KerjouanCharles LefevreBertrand de LatourJulien LetheullePierre TattevinStéphane JouneauPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257339 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
David Luque Paz
Betsega Bayeh
Pierre Chauvin
Florence Poizeau
Mathieu Lederlin
Mallorie Kerjouan
Charles Lefevre
Bertrand de Latour
Julien Letheulle
Pierre Tattevin
Stéphane Jouneau
Intrapleural use of urokinase and DNase in pleural infections managed with repeated thoracentesis: A comparative cohort study.
description <h4>Introduction</h4>Evacuation of infected fluid in pleural infections is essential. To date, the use of an intrapleural fibrinolytic agent such as urokinase and DNase has not yet been assessed in infections managed by repeated therapeutic thoracentesis (RTT).<h4>Methods</h4>We performed a retrospective comparative study of two successive cohorts of consecutive patients with pleural infections from 2001 to 2018. Between 2001 and 2010, patients had RTT with intrapleural urokinase (RTT-U). After 2011, patients received intrapleural urokinase and DNase with RTT (RTT-UD). Data were collected through a standardized questionnaire.<h4>Results</h4>One hundred and thirty-three patients were included: 93 were men and the mean age was 59 years (standard deviation 17.2). Eighty-one patients were treated with a combination of intrapleural urokinase and DNase, and 52 were treated with intrapleural urokinase only. In the RTT-UD, RTT failure occurred in 14 patients (17%) compared to 10 (19%) in the RTT-U group (P = 0.82). There was no difference between the two groups in intensive care unit admission, surgical referrals or in-hospital mortality. RTT-UD was associated with faster time to apyrexia (aOR = 0.51, 95%CI [0.37-0.72]), a reduced length of hospital stay (aOR = 0.61, 95%CI [0.52-0.73]) and a higher volume of total pleural fluid retrieved (aOR = 1.38, 95%CI [1.02-1.88]). Complications were rare with only one hemothorax in the RTT-UD group and no pneumothorax requiring drainage in either group.<h4>Conclusion</h4>Compared to urokinase only, intrapleural use of urokinase and DNase in RTT was associated with quicker defervescence, shorter hospital stay and increased volumes of pleural fluid drained. Randomized controlled trials evaluating urokinase and DNase with RTT technique would be required to confirm these results.
format article
author David Luque Paz
Betsega Bayeh
Pierre Chauvin
Florence Poizeau
Mathieu Lederlin
Mallorie Kerjouan
Charles Lefevre
Bertrand de Latour
Julien Letheulle
Pierre Tattevin
Stéphane Jouneau
author_facet David Luque Paz
Betsega Bayeh
Pierre Chauvin
Florence Poizeau
Mathieu Lederlin
Mallorie Kerjouan
Charles Lefevre
Bertrand de Latour
Julien Letheulle
Pierre Tattevin
Stéphane Jouneau
author_sort David Luque Paz
title Intrapleural use of urokinase and DNase in pleural infections managed with repeated thoracentesis: A comparative cohort study.
title_short Intrapleural use of urokinase and DNase in pleural infections managed with repeated thoracentesis: A comparative cohort study.
title_full Intrapleural use of urokinase and DNase in pleural infections managed with repeated thoracentesis: A comparative cohort study.
title_fullStr Intrapleural use of urokinase and DNase in pleural infections managed with repeated thoracentesis: A comparative cohort study.
title_full_unstemmed Intrapleural use of urokinase and DNase in pleural infections managed with repeated thoracentesis: A comparative cohort study.
title_sort intrapleural use of urokinase and dnase in pleural infections managed with repeated thoracentesis: a comparative cohort study.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/30887be71f8b4511958e8c38224f47f6
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