Relationship between tooth extraction and development of medication-related osteonecrosis of the jaw in cancer patients

Abstract Tooth extraction has been avoided since it has been considered a major risk factor for medication-related osteonecrosis of the jaw (MRONJ). However, MRONJ may also develop from tooth that is an infection source. This study aimed to clarify whether tooth extraction is a risk factor for the d...

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Autores principales:	Sakiko Soutome, Mitsunobu Otsuru, Saki Hayashida, Maho Murata, Souichi Yanamoto, Shunsuke Sawada, Yuka Kojima, Madoka Funahara, Hiroshi Iwai, Masahiro Umeda, Toshiyuki Saito
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/308972c14c074a7e83a2ce62a4209592
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spelling	oai:doaj.org-article:308972c14c074a7e83a2ce62a42095922021-12-02T16:35:05ZRelationship between tooth extraction and development of medication-related osteonecrosis of the jaw in cancer patients10.1038/s41598-021-96480-82045-2322https://doaj.org/article/308972c14c074a7e83a2ce62a42095922021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96480-8https://doaj.org/toc/2045-2322Abstract Tooth extraction has been avoided since it has been considered a major risk factor for medication-related osteonecrosis of the jaw (MRONJ). However, MRONJ may also develop from tooth that is an infection source. This study aimed to clarify whether tooth extraction is a risk factor for the development of MRONJ in cancer patients receiving bone-modifying agents (BMAs). This retrospective observational study included 189 patients (361 jaws) from two hospitals. The risk factors of MRONJ were identified by comparing patient characteristics between those who did and did not develop MRONJ. Furthermore, the effect of tooth extraction during BMA therapy was analyzed after adjusting for confounding factors using the propensity score matching method. MRONJ occurred in 33 patients jaws. A longer duration of BMA administration, fewer number of teeth, presence of symptoms of local infection, and infected teeth were independent risk factors of MRONJ. However, tooth extraction during BMA therapy did not increase the risk. Propensity score matching analysis showed that tooth extraction significantly lowered the risk of MRONJ development. Teeth that can be an infection source increases the risk of MRONJ, and thus, they need to be extracted even during BMA administration.Sakiko SoutomeMitsunobu OtsuruSaki HayashidaMaho MurataSouichi YanamotoShunsuke SawadaYuka KojimaMadoka FunaharaHiroshi IwaiMasahiro UmedaToshiyuki SaitoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sakiko Soutome Mitsunobu Otsuru Saki Hayashida Maho Murata Souichi Yanamoto Shunsuke Sawada Yuka Kojima Madoka Funahara Hiroshi Iwai Masahiro Umeda Toshiyuki Saito Relationship between tooth extraction and development of medication-related osteonecrosis of the jaw in cancer patients
description	Abstract Tooth extraction has been avoided since it has been considered a major risk factor for medication-related osteonecrosis of the jaw (MRONJ). However, MRONJ may also develop from tooth that is an infection source. This study aimed to clarify whether tooth extraction is a risk factor for the development of MRONJ in cancer patients receiving bone-modifying agents (BMAs). This retrospective observational study included 189 patients (361 jaws) from two hospitals. The risk factors of MRONJ were identified by comparing patient characteristics between those who did and did not develop MRONJ. Furthermore, the effect of tooth extraction during BMA therapy was analyzed after adjusting for confounding factors using the propensity score matching method. MRONJ occurred in 33 patients jaws. A longer duration of BMA administration, fewer number of teeth, presence of symptoms of local infection, and infected teeth were independent risk factors of MRONJ. However, tooth extraction during BMA therapy did not increase the risk. Propensity score matching analysis showed that tooth extraction significantly lowered the risk of MRONJ development. Teeth that can be an infection source increases the risk of MRONJ, and thus, they need to be extracted even during BMA administration.
format	article
author	Sakiko Soutome Mitsunobu Otsuru Saki Hayashida Maho Murata Souichi Yanamoto Shunsuke Sawada Yuka Kojima Madoka Funahara Hiroshi Iwai Masahiro Umeda Toshiyuki Saito
author_facet	Sakiko Soutome Mitsunobu Otsuru Saki Hayashida Maho Murata Souichi Yanamoto Shunsuke Sawada Yuka Kojima Madoka Funahara Hiroshi Iwai Masahiro Umeda Toshiyuki Saito
author_sort	Sakiko Soutome
title	Relationship between tooth extraction and development of medication-related osteonecrosis of the jaw in cancer patients
title_short	Relationship between tooth extraction and development of medication-related osteonecrosis of the jaw in cancer patients
title_full	Relationship between tooth extraction and development of medication-related osteonecrosis of the jaw in cancer patients
title_fullStr	Relationship between tooth extraction and development of medication-related osteonecrosis of the jaw in cancer patients
title_full_unstemmed	Relationship between tooth extraction and development of medication-related osteonecrosis of the jaw in cancer patients
title_sort	relationship between tooth extraction and development of medication-related osteonecrosis of the jaw in cancer patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/308972c14c074a7e83a2ce62a4209592
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Relationship between tooth extraction and development of medication-related osteonecrosis of the jaw in cancer patients

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