Study of Some Biochemical and Hematological Parameters Changes of Wistar Rats Blood Parallel to Oral Nanosilver Consumption

BACKGROUND AND OBJECTIVE: Nano particles because of the marvelous anti–microbe effects and increasing consumption in different industries are part of the most usable of these particles which this has increased the necessity of the study on the safety of using these materials. The aim of this study w...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	MH Razavian, E Safarpour, K Roshanai, MR Yazdian, N Heidarieh
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2011
Materias:	nano silver particles rats of wistar race cholesterol triglyceride sugar red blood cell white blood cell hemoglobin hematocrit Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3089bfa141d24fddbacf30f6fe80bbac
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3089bfa141d24fddbacf30f6fe80bbac
record_format	dspace
spelling	oai:doaj.org-article:3089bfa141d24fddbacf30f6fe80bbac2021-11-10T08:56:18ZStudy of Some Biochemical and Hematological Parameters Changes of Wistar Rats Blood Parallel to Oral Nanosilver Consumption1561-41072251-7170https://doaj.org/article/3089bfa141d24fddbacf30f6fe80bbac2011-02-01T00:00:00Zhttp://jbums.org/article-1-3713-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Nano particles because of the marvelous anti–microbe effects and increasing consumption in different industries are part of the most usable of these particles which this has increased the necessity of the study on the safety of using these materials. The aim of this study was to examine the effects of time and consumption dose of these particles on the some biochemical and blood parameters of rats of wistar race. METHODS: Thirty six Wistar race rats after 4 week similarization period divided to 6 groups of 6 rats (one control and five tests). Nanosilver (nanocid L2000) solution was purchased from NanoNasb-e-Pars Co and 95PPm, 65PPm, 35PPm, 20PPm and 5PPm concentrations were prepared. Then above solutions were used as water for 6 months. Three rats of each group were randomly selected after 3 and 6 months and biochemical parameters, Hb and HCT was measured and compared in different groups. FINDINGS: There are no significant changes in the rats blood cholesterol and sugar in the form of dose/time dependent manner in spite the fact that increasing the blood sugar level in all doses specially 35PPm after six months was considerable. The blood triglyceride level showed significantly decrease both in synchronic (p<0.01 after 3 months and p<0.05 after 6 months) and dose dependent (decreasing with p<0.01) manner. Lowering of triglyceride in 35PPm was considerable again. Counting the white blood cells shows dose dependent decreasing in number of these cells (p<0.001). No tangible change was seen on counting of red blood cells and measuring Hb and HCT parameters.CONCLUSION: The results of this study showed that oral consumption of nanosilver particles especially in high doses and long terms causes not only damage to the liver but also decrease the number of white blood cells (WBCs) and immunity level of the organism.MH RazavianE SafarpourK RoshanaiMR YazdianN HeidariehBabol University of Medical Sciencesarticlenano silver particlesrats of wistar racecholesteroltriglyceridesugarred blood cellwhite blood cellhemoglobinhematocritMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 13, Iss 1, Pp 22-27 (2011)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	nano silver particles rats of wistar race cholesterol triglyceride sugar red blood cell white blood cell hemoglobin hematocrit Medicine R Medicine (General) R5-920
spellingShingle	nano silver particles rats of wistar race cholesterol triglyceride sugar red blood cell white blood cell hemoglobin hematocrit Medicine R Medicine (General) R5-920 MH Razavian E Safarpour K Roshanai MR Yazdian N Heidarieh Study of Some Biochemical and Hematological Parameters Changes of Wistar Rats Blood Parallel to Oral Nanosilver Consumption
description	BACKGROUND AND OBJECTIVE: Nano particles because of the marvelous anti–microbe effects and increasing consumption in different industries are part of the most usable of these particles which this has increased the necessity of the study on the safety of using these materials. The aim of this study was to examine the effects of time and consumption dose of these particles on the some biochemical and blood parameters of rats of wistar race. METHODS: Thirty six Wistar race rats after 4 week similarization period divided to 6 groups of 6 rats (one control and five tests). Nanosilver (nanocid L2000) solution was purchased from NanoNasb-e-Pars Co and 95PPm, 65PPm, 35PPm, 20PPm and 5PPm concentrations were prepared. Then above solutions were used as water for 6 months. Three rats of each group were randomly selected after 3 and 6 months and biochemical parameters, Hb and HCT was measured and compared in different groups. FINDINGS: There are no significant changes in the rats blood cholesterol and sugar in the form of dose/time dependent manner in spite the fact that increasing the blood sugar level in all doses specially 35PPm after six months was considerable. The blood triglyceride level showed significantly decrease both in synchronic (p<0.01 after 3 months and p<0.05 after 6 months) and dose dependent (decreasing with p<0.01) manner. Lowering of triglyceride in 35PPm was considerable again. Counting the white blood cells shows dose dependent decreasing in number of these cells (p<0.001). No tangible change was seen on counting of red blood cells and measuring Hb and HCT parameters.CONCLUSION: The results of this study showed that oral consumption of nanosilver particles especially in high doses and long terms causes not only damage to the liver but also decrease the number of white blood cells (WBCs) and immunity level of the organism.
format	article
author	MH Razavian E Safarpour K Roshanai MR Yazdian N Heidarieh
author_facet	MH Razavian E Safarpour K Roshanai MR Yazdian N Heidarieh
author_sort	MH Razavian
title	Study of Some Biochemical and Hematological Parameters Changes of Wistar Rats Blood Parallel to Oral Nanosilver Consumption
title_short	Study of Some Biochemical and Hematological Parameters Changes of Wistar Rats Blood Parallel to Oral Nanosilver Consumption
title_full	Study of Some Biochemical and Hematological Parameters Changes of Wistar Rats Blood Parallel to Oral Nanosilver Consumption
title_fullStr	Study of Some Biochemical and Hematological Parameters Changes of Wistar Rats Blood Parallel to Oral Nanosilver Consumption
title_full_unstemmed	Study of Some Biochemical and Hematological Parameters Changes of Wistar Rats Blood Parallel to Oral Nanosilver Consumption
title_sort	study of some biochemical and hematological parameters changes of wistar rats blood parallel to oral nanosilver consumption
publisher	Babol University of Medical Sciences
publishDate	2011
url	https://doaj.org/article/3089bfa141d24fddbacf30f6fe80bbac
work_keys_str_mv	AT mhrazavian studyofsomebiochemicalandhematologicalparameterschangesofwistarratsbloodparalleltooralnanosilverconsumption AT esafarpour studyofsomebiochemicalandhematologicalparameterschangesofwistarratsbloodparalleltooralnanosilverconsumption AT kroshanai studyofsomebiochemicalandhematologicalparameterschangesofwistarratsbloodparalleltooralnanosilverconsumption AT mryazdian studyofsomebiochemicalandhematologicalparameterschangesofwistarratsbloodparalleltooralnanosilverconsumption AT nheidarieh studyofsomebiochemicalandhematologicalparameterschangesofwistarratsbloodparalleltooralnanosilverconsumption
_version_	1718440359583809536

Study of Some Biochemical and Hematological Parameters Changes of Wistar Rats Blood Parallel to Oral Nanosilver Consumption

Ejemplares similares