Nanoformulations of natural products for management of metabolic syndrome

Yasamin Davatgaran Taghipour,1–3 Marziyeh Hajialyani,4 Rozita Naseri,5 Mahvash Hesari,6 Pantea Mohammadi,6 Azzurra Stefanucci,7 Adriano Mollica,7 Mohammad Hosein Farzaei,4,6 Mohammad Abdollahi81Department of Medical Nanotechnology, School of Advanced Medical Sciences, Tabriz Unive...

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Autores principales:	Taghipour YD, Hajialyani M, Naseri R, Hesari M, Mohammadi P, Stefanucci A, Mollica A, Farzaei MH, Abdollahi M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	nanoformulations natural products metabolic syndrome diabetes Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/308c5fc0c1ff478289d9cce5ccf40e25
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spelling	oai:doaj.org-article:308c5fc0c1ff478289d9cce5ccf40e252021-12-02T08:58:15ZNanoformulations of natural products for management of metabolic syndrome1178-2013https://doaj.org/article/308c5fc0c1ff478289d9cce5ccf40e252019-07-01T00:00:00Zhttps://www.dovepress.com/nanoformulations-of-natural-products-for-management-of-metabolic-syndr-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yasamin Davatgaran Taghipour,1–3 Marziyeh Hajialyani,4 Rozita Naseri,5 Mahvash Hesari,6 Pantea Mohammadi,6 Azzurra Stefanucci,7 Adriano Mollica,7 Mohammad Hosein Farzaei,4,6 Mohammad Abdollahi81Department of Medical Nanotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; 2Phytopharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran; 3Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; 4Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 5Internal Medicine Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran; 6Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; 7Department of Pharmacy, G. d’Annunzio University of Chieti-pescara, Chieti 66100, Italy; 8Toxicology and Diseases Group, the Institute of Pharmaceutical Sciences (TIPS) and Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, IranAbstract: Metabolic syndrome is a common metabolic disorder which has become a public health challenge worldwide. There has been growing interest in medications including natural products as complementary or alternative choices for common chemical therapeutics regarding their limited side effects and ease of access. Nanosizing these compounds may help to increase their solubility, bioavailability, and promisingly enhance their efficacy. This study, for the first time, provides a comprehensive overview of the application of natural-products-based nanoformulations in the management of metabolic syndrome. Different phytochemicals including curcumin, berberine, Capsicum oleoresin, naringenin, emodin, gymnemic acid, resveratrol, quercetin, scutellarin, stevioside, silybin, baicalin, and others have been nanosized hitherto, and their nanosizing method and effect in treatment and alleviating metabolic syndrome have been reviewed and discussed in this study. It has been discovered that there are several pathways or molecular targets relevant to metabolic disorders which are affected by these compounds. Various natural-based nanoformulations have shown promising effect in treatment of metabolic syndrome, and therefore can be considered as future candidates instead of or in conjunction with pharmaceutical drugs if they pass clinical trials successfully.Keywords: nanoformulation, natural products, metabolic syndrome, diabetesTaghipour YDHajialyani MNaseri RHesari MMohammadi PStefanucci AMollica AFarzaei MHAbdollahi MDove Medical Pressarticlenanoformulationsnatural productsmetabolic syndromediabetesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 5303-5321 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoformulations natural products metabolic syndrome diabetes Medicine (General) R5-920
spellingShingle	nanoformulations natural products metabolic syndrome diabetes Medicine (General) R5-920 Taghipour YD Hajialyani M Naseri R Hesari M Mohammadi P Stefanucci A Mollica A Farzaei MH Abdollahi M Nanoformulations of natural products for management of metabolic syndrome
description	Yasamin Davatgaran Taghipour,1–3 Marziyeh Hajialyani,4 Rozita Naseri,5 Mahvash Hesari,6 Pantea Mohammadi,6 Azzurra Stefanucci,7 Adriano Mollica,7 Mohammad Hosein Farzaei,4,6 Mohammad Abdollahi81Department of Medical Nanotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; 2Phytopharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran; 3Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; 4Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 5Internal Medicine Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran; 6Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; 7Department of Pharmacy, G. d’Annunzio University of Chieti-pescara, Chieti 66100, Italy; 8Toxicology and Diseases Group, the Institute of Pharmaceutical Sciences (TIPS) and Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, IranAbstract: Metabolic syndrome is a common metabolic disorder which has become a public health challenge worldwide. There has been growing interest in medications including natural products as complementary or alternative choices for common chemical therapeutics regarding their limited side effects and ease of access. Nanosizing these compounds may help to increase their solubility, bioavailability, and promisingly enhance their efficacy. This study, for the first time, provides a comprehensive overview of the application of natural-products-based nanoformulations in the management of metabolic syndrome. Different phytochemicals including curcumin, berberine, Capsicum oleoresin, naringenin, emodin, gymnemic acid, resveratrol, quercetin, scutellarin, stevioside, silybin, baicalin, and others have been nanosized hitherto, and their nanosizing method and effect in treatment and alleviating metabolic syndrome have been reviewed and discussed in this study. It has been discovered that there are several pathways or molecular targets relevant to metabolic disorders which are affected by these compounds. Various natural-based nanoformulations have shown promising effect in treatment of metabolic syndrome, and therefore can be considered as future candidates instead of or in conjunction with pharmaceutical drugs if they pass clinical trials successfully.Keywords: nanoformulation, natural products, metabolic syndrome, diabetes
format	article
author	Taghipour YD Hajialyani M Naseri R Hesari M Mohammadi P Stefanucci A Mollica A Farzaei MH Abdollahi M
author_facet	Taghipour YD Hajialyani M Naseri R Hesari M Mohammadi P Stefanucci A Mollica A Farzaei MH Abdollahi M
author_sort	Taghipour YD
title	Nanoformulations of natural products for management of metabolic syndrome
title_short	Nanoformulations of natural products for management of metabolic syndrome
title_full	Nanoformulations of natural products for management of metabolic syndrome
title_fullStr	Nanoformulations of natural products for management of metabolic syndrome
title_full_unstemmed	Nanoformulations of natural products for management of metabolic syndrome
title_sort	nanoformulations of natural products for management of metabolic syndrome
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/308c5fc0c1ff478289d9cce5ccf40e25
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Nanoformulations of natural products for management of metabolic syndrome

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