Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations
Uterine adenomyosis often co-occurs with endometriosis or leiomyoma, but little is known about its molecular underpinnings. Here, the authors show that KRAS mutations are frequent in this disease, which might reduce sensitivity to progestin treatment via epigenetic silencing of the progesterone rece...
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Nature Portfolio
2019
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oai:doaj.org-article:308ef522cafc4a86addf3079e5ad71ee2021-12-02T15:35:37ZUterine adenomyosis is an oligoclonal disorder associated with KRAS mutations10.1038/s41467-019-13708-y2041-1723https://doaj.org/article/308ef522cafc4a86addf3079e5ad71ee2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13708-yhttps://doaj.org/toc/2041-1723Uterine adenomyosis often co-occurs with endometriosis or leiomyoma, but little is known about its molecular underpinnings. Here, the authors show that KRAS mutations are frequent in this disease, which might reduce sensitivity to progestin treatment via epigenetic silencing of the progesterone receptor.Satoshi InoueYasushi HirotaToshihide UenoYamato FukuiEmiko YoshidaTakuo HayashiShinya KojimaReina TakeyamaTaiki HashimotoTohru KiyonoMasako IkemuraAyumi TaguchiTomoki TanakaYosuke TanakaSeiji SakataKengo TakeuchiAyako MuraokaSatoko OsukaTsuyoshi SaitoKatsutoshi OdaYutaka OsugaYasuhisa TeraoMasahito KawazuHiroyuki ManoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Satoshi Inoue Yasushi Hirota Toshihide Ueno Yamato Fukui Emiko Yoshida Takuo Hayashi Shinya Kojima Reina Takeyama Taiki Hashimoto Tohru Kiyono Masako Ikemura Ayumi Taguchi Tomoki Tanaka Yosuke Tanaka Seiji Sakata Kengo Takeuchi Ayako Muraoka Satoko Osuka Tsuyoshi Saito Katsutoshi Oda Yutaka Osuga Yasuhisa Terao Masahito Kawazu Hiroyuki Mano Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations |
| description |
Uterine adenomyosis often co-occurs with endometriosis or leiomyoma, but little is known about its molecular underpinnings. Here, the authors show that KRAS mutations are frequent in this disease, which might reduce sensitivity to progestin treatment via epigenetic silencing of the progesterone receptor. |
| format |
article |
| author |
Satoshi Inoue Yasushi Hirota Toshihide Ueno Yamato Fukui Emiko Yoshida Takuo Hayashi Shinya Kojima Reina Takeyama Taiki Hashimoto Tohru Kiyono Masako Ikemura Ayumi Taguchi Tomoki Tanaka Yosuke Tanaka Seiji Sakata Kengo Takeuchi Ayako Muraoka Satoko Osuka Tsuyoshi Saito Katsutoshi Oda Yutaka Osuga Yasuhisa Terao Masahito Kawazu Hiroyuki Mano |
| author_facet |
Satoshi Inoue Yasushi Hirota Toshihide Ueno Yamato Fukui Emiko Yoshida Takuo Hayashi Shinya Kojima Reina Takeyama Taiki Hashimoto Tohru Kiyono Masako Ikemura Ayumi Taguchi Tomoki Tanaka Yosuke Tanaka Seiji Sakata Kengo Takeuchi Ayako Muraoka Satoko Osuka Tsuyoshi Saito Katsutoshi Oda Yutaka Osuga Yasuhisa Terao Masahito Kawazu Hiroyuki Mano |
| author_sort |
Satoshi Inoue |
| title |
Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations |
| title_short |
Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations |
| title_full |
Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations |
| title_fullStr |
Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations |
| title_full_unstemmed |
Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations |
| title_sort |
uterine adenomyosis is an oligoclonal disorder associated with kras mutations |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/308ef522cafc4a86addf3079e5ad71ee |
| work_keys_str_mv |
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