Type III Interferons: Emerging Roles in Autoimmunity

Type III interferons (IFNs) or the lambda IFNs (IFNLs or IFN-λs) are antimicrobial cytokines that play key roles in immune host defense at endothelial and epithelial barriers. IFNLs signal via their heterodimeric receptor, comprised of two subunits, IFNLR1 and interleukin (IL)10Rβ, which defines the...

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Autores principales:	Sindhu Manivasagam, Robyn S. Klein
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	interferon lambda autoimmune diseases Th1 cells IFNLR neuroimmunology and neuropathology Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/30974b42fe614b708565ecd69cff0406
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spelling	oai:doaj.org-article:30974b42fe614b708565ecd69cff04062021-12-01T04:24:05ZType III Interferons: Emerging Roles in Autoimmunity1664-322410.3389/fimmu.2021.764062https://doaj.org/article/30974b42fe614b708565ecd69cff04062021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.764062/fullhttps://doaj.org/toc/1664-3224Type III interferons (IFNs) or the lambda IFNs (IFNLs or IFN-λs) are antimicrobial cytokines that play key roles in immune host defense at endothelial and epithelial barriers. IFNLs signal via their heterodimeric receptor, comprised of two subunits, IFNLR1 and interleukin (IL)10Rβ, which defines the cellular specificity of the responses to the cytokines. Recent studies show that IFNL signaling regulates CD4+ T cell differentiation, favoring Th1 cells, which has led to the identification of IFNL as a putative therapeutic target for autoimmune diseases. Here, we summarize the IFNL signaling pathways during antimicrobial immunity, IFNL-mediated immunomodulation of both innate and adaptive immune cells, and induction of autoimmunity.Sindhu ManivasagamSindhu ManivasagamRobyn S. KleinRobyn S. KleinRobyn S. KleinRobyn S. KleinFrontiers Media S.A.articleinterferon lambdaautoimmune diseasesTh1 cellsIFNLRneuroimmunology and neuropathologyImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	interferon lambda autoimmune diseases Th1 cells IFNLR neuroimmunology and neuropathology Immunologic diseases. Allergy RC581-607
spellingShingle	interferon lambda autoimmune diseases Th1 cells IFNLR neuroimmunology and neuropathology Immunologic diseases. Allergy RC581-607 Sindhu Manivasagam Sindhu Manivasagam Robyn S. Klein Robyn S. Klein Robyn S. Klein Robyn S. Klein Type III Interferons: Emerging Roles in Autoimmunity
description	Type III interferons (IFNs) or the lambda IFNs (IFNLs or IFN-λs) are antimicrobial cytokines that play key roles in immune host defense at endothelial and epithelial barriers. IFNLs signal via their heterodimeric receptor, comprised of two subunits, IFNLR1 and interleukin (IL)10Rβ, which defines the cellular specificity of the responses to the cytokines. Recent studies show that IFNL signaling regulates CD4+ T cell differentiation, favoring Th1 cells, which has led to the identification of IFNL as a putative therapeutic target for autoimmune diseases. Here, we summarize the IFNL signaling pathways during antimicrobial immunity, IFNL-mediated immunomodulation of both innate and adaptive immune cells, and induction of autoimmunity.
format	article
author	Sindhu Manivasagam Sindhu Manivasagam Robyn S. Klein Robyn S. Klein Robyn S. Klein Robyn S. Klein
author_facet	Sindhu Manivasagam Sindhu Manivasagam Robyn S. Klein Robyn S. Klein Robyn S. Klein Robyn S. Klein
author_sort	Sindhu Manivasagam
title	Type III Interferons: Emerging Roles in Autoimmunity
title_short	Type III Interferons: Emerging Roles in Autoimmunity
title_full	Type III Interferons: Emerging Roles in Autoimmunity
title_fullStr	Type III Interferons: Emerging Roles in Autoimmunity
title_full_unstemmed	Type III Interferons: Emerging Roles in Autoimmunity
title_sort	type iii interferons: emerging roles in autoimmunity
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/30974b42fe614b708565ecd69cff0406
work_keys_str_mv	AT sindhumanivasagam typeiiiinterferonsemergingrolesinautoimmunity AT sindhumanivasagam typeiiiinterferonsemergingrolesinautoimmunity AT robynsklein typeiiiinterferonsemergingrolesinautoimmunity AT robynsklein typeiiiinterferonsemergingrolesinautoimmunity AT robynsklein typeiiiinterferonsemergingrolesinautoimmunity AT robynsklein typeiiiinterferonsemergingrolesinautoimmunity
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Type III Interferons: Emerging Roles in Autoimmunity

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