Effects of remifentanil and propofol on distant organ lung injury in an ischemia–reperfusion model

Our aim was to evaluate lung injury due to oxidative stress and antioxidant activity levels in an infrarenal ischemia–reperfusion model and to compare prevention effects of single and combined use of propofol and remifentanil. In this study, a total of 40 adult Wistar Albino rats were randomly divid...

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Autores principales:	Kanbak Orhan, Aydoğan Burcu, Gümüş Tülin
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	oxidative stress ischemia–reperfusion injury anesthetics intravenous Medicine R
Acceso en línea:	https://doaj.org/article/3098eedb66034590bbecb576ff6c9b48
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spelling	oai:doaj.org-article:3098eedb66034590bbecb576ff6c9b482021-12-05T14:10:55ZEffects of remifentanil and propofol on distant organ lung injury in an ischemia–reperfusion model2391-546310.1515/med-2021-0381https://doaj.org/article/3098eedb66034590bbecb576ff6c9b482021-11-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0381https://doaj.org/toc/2391-5463Our aim was to evaluate lung injury due to oxidative stress and antioxidant activity levels in an infrarenal ischemia–reperfusion model and to compare prevention effects of single and combined use of propofol and remifentanil. In this study, a total of 40 adult Wistar Albino rats were randomly divided into five groups of eight rats as SHAM, physiological saline, intraperitoneal propofol, remifentanil, and propofol and remifentanil groups. Blood and tissue samples were obtained after 80 min of reperfusion. The malondialdehyde (MDA) level, a measure of lipid peroxidation, was measured in lung tissue samples and red blood cells; additionally, total oxidant status and total antioxidant capacity of lung tissues were measured and histopathological examination was performed. Distant organ (lung) injury developed due to lower extremity ischemia–reperfusion was created by infrarenal aortic clamping. The lipid peroxidation product MDA and total oxidant levels were increased, but there was insufficient antioxidant protection both in the lung tissues and red blood cells. While propofol prevented this injury consistent with its proposed antioxidant properties; no protective effect of remifentanil was observed. On the contrary, it showed oxidative stress increasing effect. This study concluded that the antioxidant effect of propofol was suppressed by remifentanil in the case of combined use.Kanbak OrhanAydoğan BurcuGümüş TülinDe Gruyterarticleoxidative stressischemia–reperfusion injuryanestheticsintravenousMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 1673-1680 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxidative stress ischemia–reperfusion injury anesthetics intravenous Medicine R
spellingShingle	oxidative stress ischemia–reperfusion injury anesthetics intravenous Medicine R Kanbak Orhan Aydoğan Burcu Gümüş Tülin Effects of remifentanil and propofol on distant organ lung injury in an ischemia–reperfusion model
description	Our aim was to evaluate lung injury due to oxidative stress and antioxidant activity levels in an infrarenal ischemia–reperfusion model and to compare prevention effects of single and combined use of propofol and remifentanil. In this study, a total of 40 adult Wistar Albino rats were randomly divided into five groups of eight rats as SHAM, physiological saline, intraperitoneal propofol, remifentanil, and propofol and remifentanil groups. Blood and tissue samples were obtained after 80 min of reperfusion. The malondialdehyde (MDA) level, a measure of lipid peroxidation, was measured in lung tissue samples and red blood cells; additionally, total oxidant status and total antioxidant capacity of lung tissues were measured and histopathological examination was performed. Distant organ (lung) injury developed due to lower extremity ischemia–reperfusion was created by infrarenal aortic clamping. The lipid peroxidation product MDA and total oxidant levels were increased, but there was insufficient antioxidant protection both in the lung tissues and red blood cells. While propofol prevented this injury consistent with its proposed antioxidant properties; no protective effect of remifentanil was observed. On the contrary, it showed oxidative stress increasing effect. This study concluded that the antioxidant effect of propofol was suppressed by remifentanil in the case of combined use.
format	article
author	Kanbak Orhan Aydoğan Burcu Gümüş Tülin
author_facet	Kanbak Orhan Aydoğan Burcu Gümüş Tülin
author_sort	Kanbak Orhan
title	Effects of remifentanil and propofol on distant organ lung injury in an ischemia–reperfusion model
title_short	Effects of remifentanil and propofol on distant organ lung injury in an ischemia–reperfusion model
title_full	Effects of remifentanil and propofol on distant organ lung injury in an ischemia–reperfusion model
title_fullStr	Effects of remifentanil and propofol on distant organ lung injury in an ischemia–reperfusion model
title_full_unstemmed	Effects of remifentanil and propofol on distant organ lung injury in an ischemia–reperfusion model
title_sort	effects of remifentanil and propofol on distant organ lung injury in an ischemia–reperfusion model
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/3098eedb66034590bbecb576ff6c9b48
work_keys_str_mv	AT kanbakorhan effectsofremifentanilandpropofolondistantorganlunginjuryinanischemiareperfusionmodel AT aydoganburcu effectsofremifentanilandpropofolondistantorganlunginjuryinanischemiareperfusionmodel AT gumustulin effectsofremifentanilandpropofolondistantorganlunginjuryinanischemiareperfusionmodel
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Effects of remifentanil and propofol on distant organ lung injury in an ischemia–reperfusion model

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