Polyelectrolyte-Coated Mesoporous Bioactive Glasses via Layer-by-Layer Deposition for Sustained Co-Delivery of Therapeutic Ions and Drugs

In the field of bone regeneration, considerable attention has been addressed towards the use of mesoporous bioactive glasses (MBGs), as multifunctional therapeutic platforms for advanced medical devices. In fact, their extremely high exposed surface area and pore volume allow to load and the release...

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Autores principales:	Carlotta Pontremoli, Mattia Pagani, Lorenza Maddalena, Federico Carosio, Chiara Vitale-Brovarone, Sonia Fiorilli
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bone regeneration layer by layer deposition drug delivery system sustainable co-release ibuprofen copper ions Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/3099af94cde347f6bc851a2ad34d1458
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spelling	oai:doaj.org-article:3099af94cde347f6bc851a2ad34d14582021-11-25T18:42:18ZPolyelectrolyte-Coated Mesoporous Bioactive Glasses via Layer-by-Layer Deposition for Sustained Co-Delivery of Therapeutic Ions and Drugs10.3390/pharmaceutics131119521999-4923https://doaj.org/article/3099af94cde347f6bc851a2ad34d14582021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1952https://doaj.org/toc/1999-4923In the field of bone regeneration, considerable attention has been addressed towards the use of mesoporous bioactive glasses (MBGs), as multifunctional therapeutic platforms for advanced medical devices. In fact, their extremely high exposed surface area and pore volume allow to load and the release of several drugs, while their framework can be enriched with specific therapeutic ions allowing to boost the tissue regeneration. However, due to the open and easily accessible mesopore structure of MBG, the release of the incorporated therapeutic molecules shows an initial burst effect leading to unsuitable release kinetics. Hence, a still open challenge in the design of drug delivery systems based on MBGs is the control of their release behavior. In this work, Layer-by-layer (LbL) deposition of polyelectrolyte multi-layers was exploited as a powerful and versatile technique for coating the surface of Cu-substituted MBG nanoparticles with innovative multifunctional drug delivery systems for co-releasing of therapeutic copper ions (exerting pro-angiogenic and anti-bacterial effects) and an anti-inflammatory drug (ibuprofen). Two different routes were investigated: in the first strategy, chitosan and alginate were assembled by forming the multi-layered surface, and, successively, ibuprofen was loaded by incipient wetness impregnation, while in the second approach, alginate was replaced by ibuprofen, introduced as polyelectrolyte layer. Zeta-potential, TGA and FT-IR spectroscopy were measured after the addition of each polyelectrolyte layer, confirming the occurrence of the stepwise deposition. In addition, the in vitro bioactivity and the ability to modulate the release of the cargo were evaluated. The polyelectrolyte coated-MBGs were proved to retain the peculiar ability to induce hydroxyapatite formation after 7 days of soaking in Simulated Body Fluid. Both copper ions and ibuprofen were co-released over time, showing a sustained release profile up to 14 days and 24 h, respectively, with a significantly lower burst release compared to the bare MBG particles.Carlotta PontremoliMattia PaganiLorenza MaddalenaFederico CarosioChiara Vitale-BrovaroneSonia FiorilliMDPI AGarticlebone regenerationlayer by layer depositiondrug delivery systemsustainable co-releaseibuprofencopper ionsPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1952, p 1952 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bone regeneration layer by layer deposition drug delivery system sustainable co-release ibuprofen copper ions Pharmacy and materia medica RS1-441
spellingShingle	bone regeneration layer by layer deposition drug delivery system sustainable co-release ibuprofen copper ions Pharmacy and materia medica RS1-441 Carlotta Pontremoli Mattia Pagani Lorenza Maddalena Federico Carosio Chiara Vitale-Brovarone Sonia Fiorilli Polyelectrolyte-Coated Mesoporous Bioactive Glasses via Layer-by-Layer Deposition for Sustained Co-Delivery of Therapeutic Ions and Drugs
description	In the field of bone regeneration, considerable attention has been addressed towards the use of mesoporous bioactive glasses (MBGs), as multifunctional therapeutic platforms for advanced medical devices. In fact, their extremely high exposed surface area and pore volume allow to load and the release of several drugs, while their framework can be enriched with specific therapeutic ions allowing to boost the tissue regeneration. However, due to the open and easily accessible mesopore structure of MBG, the release of the incorporated therapeutic molecules shows an initial burst effect leading to unsuitable release kinetics. Hence, a still open challenge in the design of drug delivery systems based on MBGs is the control of their release behavior. In this work, Layer-by-layer (LbL) deposition of polyelectrolyte multi-layers was exploited as a powerful and versatile technique for coating the surface of Cu-substituted MBG nanoparticles with innovative multifunctional drug delivery systems for co-releasing of therapeutic copper ions (exerting pro-angiogenic and anti-bacterial effects) and an anti-inflammatory drug (ibuprofen). Two different routes were investigated: in the first strategy, chitosan and alginate were assembled by forming the multi-layered surface, and, successively, ibuprofen was loaded by incipient wetness impregnation, while in the second approach, alginate was replaced by ibuprofen, introduced as polyelectrolyte layer. Zeta-potential, TGA and FT-IR spectroscopy were measured after the addition of each polyelectrolyte layer, confirming the occurrence of the stepwise deposition. In addition, the in vitro bioactivity and the ability to modulate the release of the cargo were evaluated. The polyelectrolyte coated-MBGs were proved to retain the peculiar ability to induce hydroxyapatite formation after 7 days of soaking in Simulated Body Fluid. Both copper ions and ibuprofen were co-released over time, showing a sustained release profile up to 14 days and 24 h, respectively, with a significantly lower burst release compared to the bare MBG particles.
format	article
author	Carlotta Pontremoli Mattia Pagani Lorenza Maddalena Federico Carosio Chiara Vitale-Brovarone Sonia Fiorilli
author_facet	Carlotta Pontremoli Mattia Pagani Lorenza Maddalena Federico Carosio Chiara Vitale-Brovarone Sonia Fiorilli
author_sort	Carlotta Pontremoli
title	Polyelectrolyte-Coated Mesoporous Bioactive Glasses via Layer-by-Layer Deposition for Sustained Co-Delivery of Therapeutic Ions and Drugs
title_short	Polyelectrolyte-Coated Mesoporous Bioactive Glasses via Layer-by-Layer Deposition for Sustained Co-Delivery of Therapeutic Ions and Drugs
title_full	Polyelectrolyte-Coated Mesoporous Bioactive Glasses via Layer-by-Layer Deposition for Sustained Co-Delivery of Therapeutic Ions and Drugs
title_fullStr	Polyelectrolyte-Coated Mesoporous Bioactive Glasses via Layer-by-Layer Deposition for Sustained Co-Delivery of Therapeutic Ions and Drugs
title_full_unstemmed	Polyelectrolyte-Coated Mesoporous Bioactive Glasses via Layer-by-Layer Deposition for Sustained Co-Delivery of Therapeutic Ions and Drugs
title_sort	polyelectrolyte-coated mesoporous bioactive glasses via layer-by-layer deposition for sustained co-delivery of therapeutic ions and drugs
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3099af94cde347f6bc851a2ad34d1458
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Polyelectrolyte-Coated Mesoporous Bioactive Glasses via Layer-by-Layer Deposition for Sustained Co-Delivery of Therapeutic Ions and Drugs

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