TET2 directs mammary luminal cell differentiation and endocrine response

TET2 loss is associated with human cancers but its role in the mammary gland development and tumorigenesis is unclear. Here, the authors show that TET2–FOXP1 complex mediates demethylation of genes involved in luminal lineage commitment and endocrine response, underlying a role of TET2 loss in endoc...

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Autores principales:	Mi Ran Kim, Meng-Ju Wu, Yingsheng Zhang, Jer-Yen Yang, Chun Ju Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/309ae989265d42cca9680720580f69f9
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spelling	oai:doaj.org-article:309ae989265d42cca9680720580f69f92021-12-02T18:34:02ZTET2 directs mammary luminal cell differentiation and endocrine response10.1038/s41467-020-18129-w2041-1723https://doaj.org/article/309ae989265d42cca9680720580f69f92020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18129-whttps://doaj.org/toc/2041-1723TET2 loss is associated with human cancers but its role in the mammary gland development and tumorigenesis is unclear. Here, the authors show that TET2–FOXP1 complex mediates demethylation of genes involved in luminal lineage commitment and endocrine response, underlying a role of TET2 loss in endocrine resistant breast cancer.Mi Ran KimMeng-Ju WuYingsheng ZhangJer-Yen YangChun Ju ChangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mi Ran Kim Meng-Ju Wu Yingsheng Zhang Jer-Yen Yang Chun Ju Chang TET2 directs mammary luminal cell differentiation and endocrine response
description	TET2 loss is associated with human cancers but its role in the mammary gland development and tumorigenesis is unclear. Here, the authors show that TET2–FOXP1 complex mediates demethylation of genes involved in luminal lineage commitment and endocrine response, underlying a role of TET2 loss in endocrine resistant breast cancer.
format	article
author	Mi Ran Kim Meng-Ju Wu Yingsheng Zhang Jer-Yen Yang Chun Ju Chang
author_facet	Mi Ran Kim Meng-Ju Wu Yingsheng Zhang Jer-Yen Yang Chun Ju Chang
author_sort	Mi Ran Kim
title	TET2 directs mammary luminal cell differentiation and endocrine response
title_short	TET2 directs mammary luminal cell differentiation and endocrine response
title_full	TET2 directs mammary luminal cell differentiation and endocrine response
title_fullStr	TET2 directs mammary luminal cell differentiation and endocrine response
title_full_unstemmed	TET2 directs mammary luminal cell differentiation and endocrine response
title_sort	tet2 directs mammary luminal cell differentiation and endocrine response
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/309ae989265d42cca9680720580f69f9
work_keys_str_mv	AT mirankim tet2directsmammaryluminalcelldifferentiationandendocrineresponse AT mengjuwu tet2directsmammaryluminalcelldifferentiationandendocrineresponse AT yingshengzhang tet2directsmammaryluminalcelldifferentiationandendocrineresponse AT jeryenyang tet2directsmammaryluminalcelldifferentiationandendocrineresponse AT chunjuchang tet2directsmammaryluminalcelldifferentiationandendocrineresponse
_version_	1718377910945972224

TET2 directs mammary luminal cell differentiation and endocrine response

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