Alpha-D-glucan nanoparticulate adjuvant induces a transient inflammatory response at the injection site and targets antigen to migratory dendritic cells

Adjuvants: Discovering the next generation of vaccine boosters A plant-derived nanoparticle boosts the immune system’s response to foreign stimuli, such as vaccines, through newly discovered mechanisms. Harm HogenEsch and his team from Purdue University, USA, previously discovered that their formula...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fangjia Lu, Yung-Yi C. Mosley, Randol J. Rodriguez Rosales, Brooke E. Carmichael, Srikanth Elesela, Yuan Yao, Harm HogenEsch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/309b3535f2464af7a43554a388859336
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:309b3535f2464af7a43554a388859336
record_format	dspace
spelling	oai:doaj.org-article:309b3535f2464af7a43554a3888593362021-12-02T12:30:10ZAlpha-D-glucan nanoparticulate adjuvant induces a transient inflammatory response at the injection site and targets antigen to migratory dendritic cells10.1038/s41541-017-0007-72059-0105https://doaj.org/article/309b3535f2464af7a43554a3888593362017-02-01T00:00:00Zhttps://doi.org/10.1038/s41541-017-0007-7https://doaj.org/toc/2059-0105Adjuvants: Discovering the next generation of vaccine boosters A plant-derived nanoparticle boosts the immune system’s response to foreign stimuli, such as vaccines, through newly discovered mechanisms. Harm HogenEsch and his team from Purdue University, USA, previously discovered that their formulated nanoparticle adjuvant, Nano-11, increased immune responses to stimuli in mice. Adjuvants are formulations often co-administered with vaccines to promote interaction with the host’s immune system, conferring greater protection. In this study, the scientists found that Nano-11 functions by inducing a temporary inflammation, attracting immune cells to the injection site. The nanoparticles also facilitate the transport of the stimuli to the lymph nodes. Nano-11 is metabolized without deposition in any major internal organs, suggesting a positive safety profile. As current aluminum-based adjuvants are sometimes poorly effective and can cause local adverse reactions, nanoparticle-based potentiators such as Nano-11 may form the next generation of adjuvants.Fangjia LuYung-Yi C. MosleyRandol J. Rodriguez RosalesBrooke E. CarmichaelSrikanth EleselaYuan YaoHarm HogenEschNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 2, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Fangjia Lu Yung-Yi C. Mosley Randol J. Rodriguez Rosales Brooke E. Carmichael Srikanth Elesela Yuan Yao Harm HogenEsch Alpha-D-glucan nanoparticulate adjuvant induces a transient inflammatory response at the injection site and targets antigen to migratory dendritic cells
description	Adjuvants: Discovering the next generation of vaccine boosters A plant-derived nanoparticle boosts the immune system’s response to foreign stimuli, such as vaccines, through newly discovered mechanisms. Harm HogenEsch and his team from Purdue University, USA, previously discovered that their formulated nanoparticle adjuvant, Nano-11, increased immune responses to stimuli in mice. Adjuvants are formulations often co-administered with vaccines to promote interaction with the host’s immune system, conferring greater protection. In this study, the scientists found that Nano-11 functions by inducing a temporary inflammation, attracting immune cells to the injection site. The nanoparticles also facilitate the transport of the stimuli to the lymph nodes. Nano-11 is metabolized without deposition in any major internal organs, suggesting a positive safety profile. As current aluminum-based adjuvants are sometimes poorly effective and can cause local adverse reactions, nanoparticle-based potentiators such as Nano-11 may form the next generation of adjuvants.
format	article
author	Fangjia Lu Yung-Yi C. Mosley Randol J. Rodriguez Rosales Brooke E. Carmichael Srikanth Elesela Yuan Yao Harm HogenEsch
author_facet	Fangjia Lu Yung-Yi C. Mosley Randol J. Rodriguez Rosales Brooke E. Carmichael Srikanth Elesela Yuan Yao Harm HogenEsch
author_sort	Fangjia Lu
title	Alpha-D-glucan nanoparticulate adjuvant induces a transient inflammatory response at the injection site and targets antigen to migratory dendritic cells
title_short	Alpha-D-glucan nanoparticulate adjuvant induces a transient inflammatory response at the injection site and targets antigen to migratory dendritic cells
title_full	Alpha-D-glucan nanoparticulate adjuvant induces a transient inflammatory response at the injection site and targets antigen to migratory dendritic cells
title_fullStr	Alpha-D-glucan nanoparticulate adjuvant induces a transient inflammatory response at the injection site and targets antigen to migratory dendritic cells
title_full_unstemmed	Alpha-D-glucan nanoparticulate adjuvant induces a transient inflammatory response at the injection site and targets antigen to migratory dendritic cells
title_sort	alpha-d-glucan nanoparticulate adjuvant induces a transient inflammatory response at the injection site and targets antigen to migratory dendritic cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/309b3535f2464af7a43554a388859336
work_keys_str_mv	AT fangjialu alphadglucannanoparticulateadjuvantinducesatransientinflammatoryresponseattheinjectionsiteandtargetsantigentomigratorydendriticcells AT yungyicmosley alphadglucannanoparticulateadjuvantinducesatransientinflammatoryresponseattheinjectionsiteandtargetsantigentomigratorydendriticcells AT randoljrodriguezrosales alphadglucannanoparticulateadjuvantinducesatransientinflammatoryresponseattheinjectionsiteandtargetsantigentomigratorydendriticcells AT brookeecarmichael alphadglucannanoparticulateadjuvantinducesatransientinflammatoryresponseattheinjectionsiteandtargetsantigentomigratorydendriticcells AT srikanthelesela alphadglucannanoparticulateadjuvantinducesatransientinflammatoryresponseattheinjectionsiteandtargetsantigentomigratorydendriticcells AT yuanyao alphadglucannanoparticulateadjuvantinducesatransientinflammatoryresponseattheinjectionsiteandtargetsantigentomigratorydendriticcells AT harmhogenesch alphadglucannanoparticulateadjuvantinducesatransientinflammatoryresponseattheinjectionsiteandtargetsantigentomigratorydendriticcells
_version_	1718394389600927744

Alpha-D-glucan nanoparticulate adjuvant induces a transient inflammatory response at the injection site and targets antigen to migratory dendritic cells

Ejemplares similares