In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene

Although many neuropsychiatric risk genes are known to contribute to epigenetic regulation of gene expression, very little is known about specific chromatin-associated mechanisms that govern the formation and maintenance of neuronal connectivity. Here, the authors report that transcallosal connectiv...

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Autores principales:	Cyril J. Peter, Atsushi Saito, Yuto Hasegawa, Yuya Tanaka, Mohika Nagpal, Gabriel Perez, Emily Alway, Sergio Espeso-Gil, Tariq Fayyad, Chana Ratner, Aslihan Dincer, Achla Gupta, Lakshmi Devi, John G. Pappas, François M. Lalonde, John A. Butman, Joan C. Han, Schahram Akbarian, Atsushi Kamiya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/309feb49933f4db5a46c8a5817095314
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spelling	oai:doaj.org-article:309feb49933f4db5a46c8a58170953142021-12-02T17:01:39ZIn vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene10.1038/s41467-019-12013-y2041-1723https://doaj.org/article/309feb49933f4db5a46c8a58170953142019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12013-yhttps://doaj.org/toc/2041-1723Although many neuropsychiatric risk genes are known to contribute to epigenetic regulation of gene expression, very little is known about specific chromatin-associated mechanisms that govern the formation and maintenance of neuronal connectivity. Here, the authors report that transcallosal connectivity is critically dependent on C11orf46/ARL14EP, a nuclear protein encoded in the chromosome 11p13 WAGR risk locus, and that RNA-guided epigenetic editing of hyperexpressed Sema6a gene promoters in C11orf46-knockdown neurons resulted in normalization of expression and rescue of transcallosal dysconnectivity via repressive chromatin remodeling.Cyril J. PeterAtsushi SaitoYuto HasegawaYuya TanakaMohika NagpalGabriel PerezEmily AlwaySergio Espeso-GilTariq FayyadChana RatnerAslihan DincerAchla GuptaLakshmi DeviJohn G. PappasFrançois M. LalondeJohn A. ButmanJoan C. HanSchahram AkbarianAtsushi KamiyaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cyril J. Peter Atsushi Saito Yuto Hasegawa Yuya Tanaka Mohika Nagpal Gabriel Perez Emily Alway Sergio Espeso-Gil Tariq Fayyad Chana Ratner Aslihan Dincer Achla Gupta Lakshmi Devi John G. Pappas François M. Lalonde John A. Butman Joan C. Han Schahram Akbarian Atsushi Kamiya In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene
description	Although many neuropsychiatric risk genes are known to contribute to epigenetic regulation of gene expression, very little is known about specific chromatin-associated mechanisms that govern the formation and maintenance of neuronal connectivity. Here, the authors report that transcallosal connectivity is critically dependent on C11orf46/ARL14EP, a nuclear protein encoded in the chromosome 11p13 WAGR risk locus, and that RNA-guided epigenetic editing of hyperexpressed Sema6a gene promoters in C11orf46-knockdown neurons resulted in normalization of expression and rescue of transcallosal dysconnectivity via repressive chromatin remodeling.
format	article
author	Cyril J. Peter Atsushi Saito Yuto Hasegawa Yuya Tanaka Mohika Nagpal Gabriel Perez Emily Alway Sergio Espeso-Gil Tariq Fayyad Chana Ratner Aslihan Dincer Achla Gupta Lakshmi Devi John G. Pappas François M. Lalonde John A. Butman Joan C. Han Schahram Akbarian Atsushi Kamiya
author_facet	Cyril J. Peter Atsushi Saito Yuto Hasegawa Yuya Tanaka Mohika Nagpal Gabriel Perez Emily Alway Sergio Espeso-Gil Tariq Fayyad Chana Ratner Aslihan Dincer Achla Gupta Lakshmi Devi John G. Pappas François M. Lalonde John A. Butman Joan C. Han Schahram Akbarian Atsushi Kamiya
author_sort	Cyril J. Peter
title	In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene
title_short	In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene
title_full	In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene
title_fullStr	In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene
title_full_unstemmed	In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene
title_sort	in vivo epigenetic editing of sema6a promoter reverses transcallosal dysconnectivity caused by c11orf46/arl14ep risk gene
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/309feb49933f4db5a46c8a5817095314
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In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene

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