Analgesic and Anti-Inflammatory Activities of Sophocarpine from Sophora viciifolia Hance

Sophora viciifolia Hance is an edible plant used in traditional Chinese medicine. Sophocarpine, a tetracyclic quinolizidine alkaloid, is one of the most abundant active ingredients in Sophora viciifolia Hance. Here, we study the analgesic and anti-inflammatory effects, as well as the acute toxicity...

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Auteurs principaux:	F. L. Wang, H. Wang, J. H. Wang, D. X. Wang, Y. Gao, B. Yang, H. J. Yang, Y. B. Ji, G. S. Xin
Format:	article
Langue:	EN
Publié:	Hindawi Limited 2021
Sujets:	Medicine R
Accès en ligne:	https://doaj.org/article/30a11709875c4667b32892d5726625f5
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spelling	oai:doaj.org-article:30a11709875c4667b32892d5726625f52021-11-22T01:10:43ZAnalgesic and Anti-Inflammatory Activities of Sophocarpine from Sophora viciifolia Hance2314-614110.1155/2021/8893563https://doaj.org/article/30a11709875c4667b32892d5726625f52021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/8893563https://doaj.org/toc/2314-6141Sophora viciifolia Hance is an edible plant used in traditional Chinese medicine. Sophocarpine, a tetracyclic quinolizidine alkaloid, is one of the most abundant active ingredients in Sophora viciifolia Hance. Here, we study the analgesic and anti-inflammatory effects, as well as the acute toxicity of sophocarpine from Sophora viciifolia Hance in mice. Sophocarpine (20, 40, and 80 mg/kgbw) significantly prolonged the delay period before a hot plate reaction occurred (all P<0.05), and the delay before a tail-flick response was induced by a warm bath (P<0.05; P<0.01). Sophocarpine (40, 80 mg/kg) resulted in dose-dependent inhibition of the writhing reaction induced by acetic acid in mice (P<0.05; P<0.001, respectively). Sophocarpine (80 mg/kg) reduced the total duration of a formalin-induced pain response (P<0.05). Sophocarpine prolonged the foot-licking latency of mice after the hot plate reaction, and this effect was antagonized by calcium chloride and enhanced by verapamil. Sophocarpine (20, 40, and 80 mg/kg) significantly inhibited xylene-induced ear edema (P<0.01; P<0.001; P<0.001, respectively) and the penetration of acetic acid-induced dye into the peritoneal cavity (P<0.01; P<0.01; P<0.001, respectively). It also reduced the levels of proinflammatory cytokine interleukin (IL)-1β, IL-6, and prostaglandin E2 (P<0.05, P<0.01, P<0.001) and those of serum nitric oxide (P<0.05). The results of this study suggest that sophocarpine possesses certain analgesic and anti-inflammatory activities, which may be related to calcium and inhibition of the secretion of inflammatory factors.F. L. WangH. WangJ. H. WangD. X. WangY. GaoB. YangH. J. YangY. B. JiG. S. XinHindawi LimitedarticleMedicineRENBioMed Research International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R F. L. Wang H. Wang J. H. Wang D. X. Wang Y. Gao B. Yang H. J. Yang Y. B. Ji G. S. Xin Analgesic and Anti-Inflammatory Activities of Sophocarpine from Sophora viciifolia Hance
description	Sophora viciifolia Hance is an edible plant used in traditional Chinese medicine. Sophocarpine, a tetracyclic quinolizidine alkaloid, is one of the most abundant active ingredients in Sophora viciifolia Hance. Here, we study the analgesic and anti-inflammatory effects, as well as the acute toxicity of sophocarpine from Sophora viciifolia Hance in mice. Sophocarpine (20, 40, and 80 mg/kgbw) significantly prolonged the delay period before a hot plate reaction occurred (all P<0.05), and the delay before a tail-flick response was induced by a warm bath (P<0.05; P<0.01). Sophocarpine (40, 80 mg/kg) resulted in dose-dependent inhibition of the writhing reaction induced by acetic acid in mice (P<0.05; P<0.001, respectively). Sophocarpine (80 mg/kg) reduced the total duration of a formalin-induced pain response (P<0.05). Sophocarpine prolonged the foot-licking latency of mice after the hot plate reaction, and this effect was antagonized by calcium chloride and enhanced by verapamil. Sophocarpine (20, 40, and 80 mg/kg) significantly inhibited xylene-induced ear edema (P<0.01; P<0.001; P<0.001, respectively) and the penetration of acetic acid-induced dye into the peritoneal cavity (P<0.01; P<0.01; P<0.001, respectively). It also reduced the levels of proinflammatory cytokine interleukin (IL)-1β, IL-6, and prostaglandin E2 (P<0.05, P<0.01, P<0.001) and those of serum nitric oxide (P<0.05). The results of this study suggest that sophocarpine possesses certain analgesic and anti-inflammatory activities, which may be related to calcium and inhibition of the secretion of inflammatory factors.
format	article
author	F. L. Wang H. Wang J. H. Wang D. X. Wang Y. Gao B. Yang H. J. Yang Y. B. Ji G. S. Xin
author_facet	F. L. Wang H. Wang J. H. Wang D. X. Wang Y. Gao B. Yang H. J. Yang Y. B. Ji G. S. Xin
author_sort	F. L. Wang
title	Analgesic and Anti-Inflammatory Activities of Sophocarpine from Sophora viciifolia Hance
title_short	Analgesic and Anti-Inflammatory Activities of Sophocarpine from Sophora viciifolia Hance
title_full	Analgesic and Anti-Inflammatory Activities of Sophocarpine from Sophora viciifolia Hance
title_fullStr	Analgesic and Anti-Inflammatory Activities of Sophocarpine from Sophora viciifolia Hance
title_full_unstemmed	Analgesic and Anti-Inflammatory Activities of Sophocarpine from Sophora viciifolia Hance
title_sort	analgesic and anti-inflammatory activities of sophocarpine from sophora viciifolia hance
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/30a11709875c4667b32892d5726625f5
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Analgesic and Anti-Inflammatory Activities of Sophocarpine from Sophora viciifolia Hance

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