Patterning artificial lipid bilayer on nanostructured surfaces

Ranjita Ghosh Moulick,1 Gregor Panaitov,2 Sung-Eun Choi,2 Dirk Mayer,2 Andreas Offenhäusser2 1School of Physical Science, Jawaharlal Nehru University, New Delhi, India; 2Bioelectronics, ICS8/PGI8, Forschungszentrum Juelich, Juelich, Germany Abstract: Artificial lipid bilayer on solid subs...

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Autores principales:	Ghosh Moulick R, Panaitov G, Choi SE, Mayer D, Offenhäusser A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Gold-Niobium FARP EphrinA5 Lipid bilayer neurodegenerative diseases Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/30a39e67610e40de8734b1d89144eef1
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spelling	oai:doaj.org-article:30a39e67610e40de8734b1d89144eef12021-12-02T02:52:35ZPatterning artificial lipid bilayer on nanostructured surfaces1178-2013https://doaj.org/article/30a39e67610e40de8734b1d89144eef12018-03-01T00:00:00Zhttps://www.dovepress.com/patterning-artificial-lipid-bilayer-on-nanostructured-surfaces-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ranjita Ghosh Moulick,1 Gregor Panaitov,2 Sung-Eun Choi,2 Dirk Mayer,2 Andreas Offenhäusser2 1School of Physical Science, Jawaharlal Nehru University, New Delhi, India; 2Bioelectronics, ICS8/PGI8, Forschungszentrum Juelich, Juelich, Germany Abstract: Artificial lipid bilayer on solid substrate plays an important role as an interface between nanotechnology and biology. In this study, grid structures were patterned on Au-Nb-glass substrate and artificial bilayer was prepared on these structures. The fluidity was checked using fluorescence recovery after photobleaching (FRAP), and neuronal adhesion was monitored on such structure using EphrinA5-tethered lipid bilayer. EphrinA5 is a ligand that binds to the Eph receptors of rat cortical neurons and influences cellular adhesion. Our result elucidated that influence of these nanopatterned protein-tethered lipid bilayer on cellular guidance and signaling can address many underlying mechanisms of cellular functioning and help us to understand and differentiate the signaling procedure in cancer and neurodegenerative diseases. Keywords: Au-Nb, FRAP, EphrinA5, lipid bilayer, neurodegenerative diseasesGhosh Moulick RPanaitov GChoi SEMayer DOffenhäusser ADove Medical PressarticleGold-NiobiumFARPEphrinA5Lipid bilayerneurodegenerative diseasesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 55-58 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gold-Niobium FARP EphrinA5 Lipid bilayer neurodegenerative diseases Medicine (General) R5-920
spellingShingle	Gold-Niobium FARP EphrinA5 Lipid bilayer neurodegenerative diseases Medicine (General) R5-920 Ghosh Moulick R Panaitov G Choi SE Mayer D Offenhäusser A Patterning artificial lipid bilayer on nanostructured surfaces
description	Ranjita Ghosh Moulick,1 Gregor Panaitov,2 Sung-Eun Choi,2 Dirk Mayer,2 Andreas Offenhäusser2 1School of Physical Science, Jawaharlal Nehru University, New Delhi, India; 2Bioelectronics, ICS8/PGI8, Forschungszentrum Juelich, Juelich, Germany Abstract: Artificial lipid bilayer on solid substrate plays an important role as an interface between nanotechnology and biology. In this study, grid structures were patterned on Au-Nb-glass substrate and artificial bilayer was prepared on these structures. The fluidity was checked using fluorescence recovery after photobleaching (FRAP), and neuronal adhesion was monitored on such structure using EphrinA5-tethered lipid bilayer. EphrinA5 is a ligand that binds to the Eph receptors of rat cortical neurons and influences cellular adhesion. Our result elucidated that influence of these nanopatterned protein-tethered lipid bilayer on cellular guidance and signaling can address many underlying mechanisms of cellular functioning and help us to understand and differentiate the signaling procedure in cancer and neurodegenerative diseases. Keywords: Au-Nb, FRAP, EphrinA5, lipid bilayer, neurodegenerative diseases
format	article
author	Ghosh Moulick R Panaitov G Choi SE Mayer D Offenhäusser A
author_facet	Ghosh Moulick R Panaitov G Choi SE Mayer D Offenhäusser A
author_sort	Ghosh Moulick R
title	Patterning artificial lipid bilayer on nanostructured surfaces
title_short	Patterning artificial lipid bilayer on nanostructured surfaces
title_full	Patterning artificial lipid bilayer on nanostructured surfaces
title_fullStr	Patterning artificial lipid bilayer on nanostructured surfaces
title_full_unstemmed	Patterning artificial lipid bilayer on nanostructured surfaces
title_sort	patterning artificial lipid bilayer on nanostructured surfaces
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/30a39e67610e40de8734b1d89144eef1
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_version_	1718402093793935360

Patterning artificial lipid bilayer on nanostructured surfaces

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