Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development

How the imprinted Cdkn1c locus regulates corticogenesis is unclear. Here, the authors dissect the level of cell-autonomy of imprinted Cdkn1c gene function in mouse corticogenesis and identify this as regulating radial glial progenitor cell and projection neuron survival.

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Autores principales:	Susanne Laukoter, Robert Beattie, Florian M. Pauler, Nicole Amberg, Keiichi I. Nakayama, Simon Hippenmeyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/30a406ce09274ca2817830f81bfa62fe
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spelling	oai:doaj.org-article:30a406ce09274ca2817830f81bfa62fe2021-12-02T15:37:17ZImprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development10.1038/s41467-019-14077-22041-1723https://doaj.org/article/30a406ce09274ca2817830f81bfa62fe2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14077-2https://doaj.org/toc/2041-1723How the imprinted Cdkn1c locus regulates corticogenesis is unclear. Here, the authors dissect the level of cell-autonomy of imprinted Cdkn1c gene function in mouse corticogenesis and identify this as regulating radial glial progenitor cell and projection neuron survival.Susanne LaukoterRobert BeattieFlorian M. PaulerNicole AmbergKeiichi I. NakayamaSimon HippenmeyerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Susanne Laukoter Robert Beattie Florian M. Pauler Nicole Amberg Keiichi I. Nakayama Simon Hippenmeyer Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development
description	How the imprinted Cdkn1c locus regulates corticogenesis is unclear. Here, the authors dissect the level of cell-autonomy of imprinted Cdkn1c gene function in mouse corticogenesis and identify this as regulating radial glial progenitor cell and projection neuron survival.
format	article
author	Susanne Laukoter Robert Beattie Florian M. Pauler Nicole Amberg Keiichi I. Nakayama Simon Hippenmeyer
author_facet	Susanne Laukoter Robert Beattie Florian M. Pauler Nicole Amberg Keiichi I. Nakayama Simon Hippenmeyer
author_sort	Susanne Laukoter
title	Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development
title_short	Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development
title_full	Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development
title_fullStr	Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development
title_full_unstemmed	Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development
title_sort	imprinted cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/30a406ce09274ca2817830f81bfa62fe
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Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development

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