Chromatin fibers stabilize nucleosomes under torsional stress

Torsional stress is generated during DNA replication and transcription, however, the propagation of twist in condensed chromatin is poorly understood. Here the authors measure how force and torque impact chromatin fibers and find that the fibers fold into a left-handed superhelix that can be stabili...

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Autores principales:	Artur Kaczmarczyk, He Meng, Orkide Ordu, John van Noort, Nynke H. Dekker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/30a70ffb95644882808b1311d671a36e
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spelling	oai:doaj.org-article:30a70ffb95644882808b1311d671a36e2021-12-02T15:39:16ZChromatin fibers stabilize nucleosomes under torsional stress10.1038/s41467-019-13891-y2041-1723https://doaj.org/article/30a70ffb95644882808b1311d671a36e2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13891-yhttps://doaj.org/toc/2041-1723Torsional stress is generated during DNA replication and transcription, however, the propagation of twist in condensed chromatin is poorly understood. Here the authors measure how force and torque impact chromatin fibers and find that the fibers fold into a left-handed superhelix that can be stabilized by positive torsion, suggesting that chromatin fibers stabilize nucleosomes under torsional stress.Artur KaczmarczykHe MengOrkide OrduJohn van NoortNynke H. DekkerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Artur Kaczmarczyk He Meng Orkide Ordu John van Noort Nynke H. Dekker Chromatin fibers stabilize nucleosomes under torsional stress
description	Torsional stress is generated during DNA replication and transcription, however, the propagation of twist in condensed chromatin is poorly understood. Here the authors measure how force and torque impact chromatin fibers and find that the fibers fold into a left-handed superhelix that can be stabilized by positive torsion, suggesting that chromatin fibers stabilize nucleosomes under torsional stress.
format	article
author	Artur Kaczmarczyk He Meng Orkide Ordu John van Noort Nynke H. Dekker
author_facet	Artur Kaczmarczyk He Meng Orkide Ordu John van Noort Nynke H. Dekker
author_sort	Artur Kaczmarczyk
title	Chromatin fibers stabilize nucleosomes under torsional stress
title_short	Chromatin fibers stabilize nucleosomes under torsional stress
title_full	Chromatin fibers stabilize nucleosomes under torsional stress
title_fullStr	Chromatin fibers stabilize nucleosomes under torsional stress
title_full_unstemmed	Chromatin fibers stabilize nucleosomes under torsional stress
title_sort	chromatin fibers stabilize nucleosomes under torsional stress
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/30a70ffb95644882808b1311d671a36e
work_keys_str_mv	AT arturkaczmarczyk chromatinfibersstabilizenucleosomesundertorsionalstress AT hemeng chromatinfibersstabilizenucleosomesundertorsionalstress AT orkideordu chromatinfibersstabilizenucleosomesundertorsionalstress AT johnvannoort chromatinfibersstabilizenucleosomesundertorsionalstress AT nynkehdekker chromatinfibersstabilizenucleosomesundertorsionalstress
_version_	1718385924311613440

Chromatin fibers stabilize nucleosomes under torsional stress

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