Prognostic Potential of Liver Enzymes in Patients With COVID-19 at the Leishenshan Hospital in Wuhan
BackgroundCoronavirus disease 2019 (COVID-19) has evolved into a pandemic. We hypothesized that biochemical indicators of liver function may help determine the prognosis of COVID-19 patients.MethodsPatient information was collected from the Wuhan-Leishenshan hospital. Logistic and Cox regression ana...
Guardado en:
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/30a8685127404c2e804a9f1925dbf4be |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:30a8685127404c2e804a9f1925dbf4be |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:30a8685127404c2e804a9f1925dbf4be2021-11-16T06:34:05ZPrognostic Potential of Liver Enzymes in Patients With COVID-19 at the Leishenshan Hospital in Wuhan2235-298810.3389/fcimb.2021.636999https://doaj.org/article/30a8685127404c2e804a9f1925dbf4be2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.636999/fullhttps://doaj.org/toc/2235-2988BackgroundCoronavirus disease 2019 (COVID-19) has evolved into a pandemic. We hypothesized that biochemical indicators of liver function may help determine the prognosis of COVID-19 patients.MethodsPatient information was collected from the Wuhan-Leishenshan hospital. Logistic and Cox regression analyses, Kaplan-Meier curves, and Curve fitting were used to determine the correlation between elevated levels of aspartate transaminase (AST), alanine transaminase (ALT), and AST/ALT and severity of disease/mortality.ResultsLogistic and Cox regression analyses and Kaplan-Meier survival curves showed that COVID-19 progression correlated with elevated levels of AST and AST/ALT. The odds ratios for elevated levels of AST and AST/ALT in patients were 0.818 (95% confidence interval [CI]: 0.274-2.441, P = 0.035) and 2.055 (95% CI: 1.269-3.327, P = 0.003), respectively; the hazard ratios were 4.195 (95% CI: 1.219-14.422, P = 0.023) and 3.348 (95% CI: 1.57-7.139, P = 0.002), respectively. The Kaplan-Meier survival curves demonstrated that patients with elevated AST and AST/ALT levels had a higher risk of developing severe COVID-19.ConclusionElevated AST and AST/ALT levels correlated with severity of COVID-19 and mortality. Liver function tests may help clinicians in determining the prognosis of patients undergoing treatment for COVID-19.Zeming LiuDi HuJinpeng LiQing XiaYan GongZhengwei LiQian WuMeilin YiYihui HuangMeng WuLiang GuoXiaohui WuFrontiers Media S.A.articleAST - aspartate transaminaseALT - alanine transaminaseAST/ALTaspartate aminotransferase/alanine aminotransferaseCOVID-19pneumoniaMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
AST - aspartate transaminase ALT - alanine transaminase AST/ALT aspartate aminotransferase/alanine aminotransferase COVID-19 pneumonia Microbiology QR1-502 |
| spellingShingle |
AST - aspartate transaminase ALT - alanine transaminase AST/ALT aspartate aminotransferase/alanine aminotransferase COVID-19 pneumonia Microbiology QR1-502 Zeming Liu Di Hu Jinpeng Li Qing Xia Yan Gong Zhengwei Li Qian Wu Meilin Yi Yihui Huang Meng Wu Liang Guo Xiaohui Wu Prognostic Potential of Liver Enzymes in Patients With COVID-19 at the Leishenshan Hospital in Wuhan |
| description |
BackgroundCoronavirus disease 2019 (COVID-19) has evolved into a pandemic. We hypothesized that biochemical indicators of liver function may help determine the prognosis of COVID-19 patients.MethodsPatient information was collected from the Wuhan-Leishenshan hospital. Logistic and Cox regression analyses, Kaplan-Meier curves, and Curve fitting were used to determine the correlation between elevated levels of aspartate transaminase (AST), alanine transaminase (ALT), and AST/ALT and severity of disease/mortality.ResultsLogistic and Cox regression analyses and Kaplan-Meier survival curves showed that COVID-19 progression correlated with elevated levels of AST and AST/ALT. The odds ratios for elevated levels of AST and AST/ALT in patients were 0.818 (95% confidence interval [CI]: 0.274-2.441, P = 0.035) and 2.055 (95% CI: 1.269-3.327, P = 0.003), respectively; the hazard ratios were 4.195 (95% CI: 1.219-14.422, P = 0.023) and 3.348 (95% CI: 1.57-7.139, P = 0.002), respectively. The Kaplan-Meier survival curves demonstrated that patients with elevated AST and AST/ALT levels had a higher risk of developing severe COVID-19.ConclusionElevated AST and AST/ALT levels correlated with severity of COVID-19 and mortality. Liver function tests may help clinicians in determining the prognosis of patients undergoing treatment for COVID-19. |
| format |
article |
| author |
Zeming Liu Di Hu Jinpeng Li Qing Xia Yan Gong Zhengwei Li Qian Wu Meilin Yi Yihui Huang Meng Wu Liang Guo Xiaohui Wu |
| author_facet |
Zeming Liu Di Hu Jinpeng Li Qing Xia Yan Gong Zhengwei Li Qian Wu Meilin Yi Yihui Huang Meng Wu Liang Guo Xiaohui Wu |
| author_sort |
Zeming Liu |
| title |
Prognostic Potential of Liver Enzymes in Patients With COVID-19 at the Leishenshan Hospital in Wuhan |
| title_short |
Prognostic Potential of Liver Enzymes in Patients With COVID-19 at the Leishenshan Hospital in Wuhan |
| title_full |
Prognostic Potential of Liver Enzymes in Patients With COVID-19 at the Leishenshan Hospital in Wuhan |
| title_fullStr |
Prognostic Potential of Liver Enzymes in Patients With COVID-19 at the Leishenshan Hospital in Wuhan |
| title_full_unstemmed |
Prognostic Potential of Liver Enzymes in Patients With COVID-19 at the Leishenshan Hospital in Wuhan |
| title_sort |
prognostic potential of liver enzymes in patients with covid-19 at the leishenshan hospital in wuhan |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/30a8685127404c2e804a9f1925dbf4be |
| work_keys_str_mv |
AT zemingliu prognosticpotentialofliverenzymesinpatientswithcovid19attheleishenshanhospitalinwuhan AT dihu prognosticpotentialofliverenzymesinpatientswithcovid19attheleishenshanhospitalinwuhan AT jinpengli prognosticpotentialofliverenzymesinpatientswithcovid19attheleishenshanhospitalinwuhan AT qingxia prognosticpotentialofliverenzymesinpatientswithcovid19attheleishenshanhospitalinwuhan AT yangong prognosticpotentialofliverenzymesinpatientswithcovid19attheleishenshanhospitalinwuhan AT zhengweili prognosticpotentialofliverenzymesinpatientswithcovid19attheleishenshanhospitalinwuhan AT qianwu prognosticpotentialofliverenzymesinpatientswithcovid19attheleishenshanhospitalinwuhan AT meilinyi prognosticpotentialofliverenzymesinpatientswithcovid19attheleishenshanhospitalinwuhan AT yihuihuang prognosticpotentialofliverenzymesinpatientswithcovid19attheleishenshanhospitalinwuhan AT mengwu prognosticpotentialofliverenzymesinpatientswithcovid19attheleishenshanhospitalinwuhan AT liangguo prognosticpotentialofliverenzymesinpatientswithcovid19attheleishenshanhospitalinwuhan AT xiaohuiwu prognosticpotentialofliverenzymesinpatientswithcovid19attheleishenshanhospitalinwuhan |
| _version_ |
1718426658602483712 |