An elastic element in the protocadherin-15 tip link of the inner ear

Tip-link filaments convey force to activate hair cells, important sensory receptors. Here the authors solve a partial structure of human protocadherin-15, a tip-link component with an unusual Ca2+–free linker that bends and is predicted to confer flexibility to this filament during inner-ear mechano...

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Autores principales:	Raul Araya-Secchi, Brandon L. Neel, Marcos Sotomayor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/30a8a2d6da894b47aea927d90ea31194
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spelling	oai:doaj.org-article:30a8a2d6da894b47aea927d90ea311942021-12-02T15:34:59ZAn elastic element in the protocadherin-15 tip link of the inner ear10.1038/ncomms134582041-1723https://doaj.org/article/30a8a2d6da894b47aea927d90ea311942016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13458https://doaj.org/toc/2041-1723Tip-link filaments convey force to activate hair cells, important sensory receptors. Here the authors solve a partial structure of human protocadherin-15, a tip-link component with an unusual Ca2+–free linker that bends and is predicted to confer flexibility to this filament during inner-ear mechanotransduction.Raul Araya-SecchiBrandon L. NeelMarcos SotomayorNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raul Araya-Secchi Brandon L. Neel Marcos Sotomayor An elastic element in the protocadherin-15 tip link of the inner ear
description	Tip-link filaments convey force to activate hair cells, important sensory receptors. Here the authors solve a partial structure of human protocadherin-15, a tip-link component with an unusual Ca2+–free linker that bends and is predicted to confer flexibility to this filament during inner-ear mechanotransduction.
format	article
author	Raul Araya-Secchi Brandon L. Neel Marcos Sotomayor
author_facet	Raul Araya-Secchi Brandon L. Neel Marcos Sotomayor
author_sort	Raul Araya-Secchi
title	An elastic element in the protocadherin-15 tip link of the inner ear
title_short	An elastic element in the protocadherin-15 tip link of the inner ear
title_full	An elastic element in the protocadherin-15 tip link of the inner ear
title_fullStr	An elastic element in the protocadherin-15 tip link of the inner ear
title_full_unstemmed	An elastic element in the protocadherin-15 tip link of the inner ear
title_sort	elastic element in the protocadherin-15 tip link of the inner ear
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/30a8a2d6da894b47aea927d90ea31194
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An elastic element in the protocadherin-15 tip link of the inner ear

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