A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers

A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers

Promoter-proximal transcripts have been proposed to act ascis-acting elements regulating transcription. Here, the authors provide evidence that a promoter-proximal RNA, in combination with other epigenetic regulators, controls transcription of E-cadherin in epithelial cancers.

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Detalles Bibliográficos
Autores principales: Giuseppina Pisignano, Sara Napoli, Marco Magistri, Sarah N. Mapelli, Chiara Pastori, Stefano Di Marco, Gianluca Civenni, Domenico Albino, Claudia Enriquez, Sara Allegrini, Abhishek Mitra, Gioacchino D’Ambrosio, Maurizia Mello-Grand, Giovanna Chiorino, Ramon Garcia-Escudero, Gabriele Varani, Giuseppina M. Carbone, Carlo V. Catapano
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/30abb6e59ccc403ba1c9e976c95d4eef
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Descripción
Sumario:Promoter-proximal transcripts have been proposed to act ascis-acting elements regulating transcription. Here, the authors provide evidence that a promoter-proximal RNA, in combination with other epigenetic regulators, controls transcription of E-cadherin in epithelial cancers.

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