A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers

A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers

Promoter-proximal transcripts have been proposed to act ascis-acting elements regulating transcription. Here, the authors provide evidence that a promoter-proximal RNA, in combination with other epigenetic regulators, controls transcription of E-cadherin in epithelial cancers.

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Autores principales: Giuseppina Pisignano, Sara Napoli, Marco Magistri, Sarah N. Mapelli, Chiara Pastori, Stefano Di Marco, Gianluca Civenni, Domenico Albino, Claudia Enriquez, Sara Allegrini, Abhishek Mitra, Gioacchino D’Ambrosio, Maurizia Mello-Grand, Giovanna Chiorino, Ramon Garcia-Escudero, Gabriele Varani, Giuseppina M. Carbone, Carlo V. Catapano
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/30abb6e59ccc403ba1c9e976c95d4eef
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spelling oai:doaj.org-article:30abb6e59ccc403ba1c9e976c95d4eef2021-12-02T14:40:46ZA promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers10.1038/ncomms156222041-1723https://doaj.org/article/30abb6e59ccc403ba1c9e976c95d4eef2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15622https://doaj.org/toc/2041-1723Promoter-proximal transcripts have been proposed to act ascis-acting elements regulating transcription. Here, the authors provide evidence that a promoter-proximal RNA, in combination with other epigenetic regulators, controls transcription of E-cadherin in epithelial cancers.Giuseppina PisignanoSara NapoliMarco MagistriSarah N. MapelliChiara PastoriStefano Di MarcoGianluca CivenniDomenico AlbinoClaudia EnriquezSara AllegriniAbhishek MitraGioacchino D’AmbrosioMaurizia Mello-GrandGiovanna ChiorinoRamon Garcia-EscuderoGabriele VaraniGiuseppina M. CarboneCarlo V. CatapanoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Giuseppina Pisignano
Sara Napoli
Marco Magistri
Sarah N. Mapelli
Chiara Pastori
Stefano Di Marco
Gianluca Civenni
Domenico Albino
Claudia Enriquez
Sara Allegrini
Abhishek Mitra
Gioacchino D’Ambrosio
Maurizia Mello-Grand
Giovanna Chiorino
Ramon Garcia-Escudero
Gabriele Varani
Giuseppina M. Carbone
Carlo V. Catapano
A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers
description Promoter-proximal transcripts have been proposed to act ascis-acting elements regulating transcription. Here, the authors provide evidence that a promoter-proximal RNA, in combination with other epigenetic regulators, controls transcription of E-cadherin in epithelial cancers.
format article
author Giuseppina Pisignano
Sara Napoli
Marco Magistri
Sarah N. Mapelli
Chiara Pastori
Stefano Di Marco
Gianluca Civenni
Domenico Albino
Claudia Enriquez
Sara Allegrini
Abhishek Mitra
Gioacchino D’Ambrosio
Maurizia Mello-Grand
Giovanna Chiorino
Ramon Garcia-Escudero
Gabriele Varani
Giuseppina M. Carbone
Carlo V. Catapano
author_facet Giuseppina Pisignano
Sara Napoli
Marco Magistri
Sarah N. Mapelli
Chiara Pastori
Stefano Di Marco
Gianluca Civenni
Domenico Albino
Claudia Enriquez
Sara Allegrini
Abhishek Mitra
Gioacchino D’Ambrosio
Maurizia Mello-Grand
Giovanna Chiorino
Ramon Garcia-Escudero
Gabriele Varani
Giuseppina M. Carbone
Carlo V. Catapano
author_sort Giuseppina Pisignano
title A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers
title_short A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers
title_full A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers
title_fullStr A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers
title_full_unstemmed A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers
title_sort promoter-proximal transcript targeted by genetic polymorphism controls e-cadherin silencing in human cancers
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/30abb6e59ccc403ba1c9e976c95d4eef
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