A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers
Promoter-proximal transcripts have been proposed to act ascis-acting elements regulating transcription. Here, the authors provide evidence that a promoter-proximal RNA, in combination with other epigenetic regulators, controls transcription of E-cadherin in epithelial cancers.
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Main Authors: | Giuseppina Pisignano, Sara Napoli, Marco Magistri, Sarah N. Mapelli, Chiara Pastori, Stefano Di Marco, Gianluca Civenni, Domenico Albino, Claudia Enriquez, Sara Allegrini, Abhishek Mitra, Gioacchino D’Ambrosio, Maurizia Mello-Grand, Giovanna Chiorino, Ramon Garcia-Escudero, Gabriele Varani, Giuseppina M. Carbone, Carlo V. Catapano |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2017
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Subjects: | |
Online Access: | https://doaj.org/article/30abb6e59ccc403ba1c9e976c95d4eef |
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